Glucose turnover and defense of blood glucose levels in arctic fox (Alopex lagopus)

1988 ◽  
Vol 91 (3) ◽  
pp. 493-498 ◽  
Author(s):  
Peter G Tallas ◽  
Robert G White
1988 ◽  
Vol 254 (2) ◽  
pp. E137-E143 ◽  
Author(s):  
S. Hulman ◽  
R. Kliegman ◽  
J. Heng ◽  
E. Crouser

Glucose turnover, clearance and response to insulin were determined in fasted newborn and adult dogs. Fasting levels of glucose and insulin and rates of glucose turnover and clearance were not different between the two groups. Blood glucose correlated with basal glucose turnover in newborn pups but not in adult dogs. Glucose turnover was not related to fasting plasma insulin levels. Glucose clearance was an inverse function of blood glucose levels among newborn but not adult dogs. Glucose clearance and blood glucose levels were not related to insulin concentrations. In response to euglycemic hyperinsulinemia, glucose metabolism increased 4-fold among adults but only 1.7-fold in pups. Hyperglycemic hyperinsulinemia increased glucose metabolism in both groups but to a much greater extent in the pups. Euglycemic hyperinsulinemia increased the metabolic clearance rate of glucose 4.2-fold among adults but only 1.8-fold in newborn dogs. In response to hyperglycemic hyperinsulinemia glucose clearance rates were now similar. Despite euglycemic hyperinsulinemia, the newborn dog had an attenuated response to insulin, demonstrating lower rates of glucose metabolism and glucose clearance. The response to the hyperglycemic stimuli suggests that maximal glucose uptake was not achieved during hyperinsulinemia alone. This response supports the concept of glucose-mediated regulation of glucose disposal in newborn animals.


1983 ◽  
Vol 244 (5) ◽  
pp. E505-E512 ◽  
Author(s):  
G. A. Brooks ◽  
C. M. Donovan

Control and endurance-trained rats received continuous infusions via jugular catheters of [U-14C]- and [6-3H]glucose under one of three conditions: rest (Re), running at 13.4 m/min (easy exercise, EE), or running at 26.8 m/min (hard exercise, HE). Arterial blood was sampled from carotid catheters. Blood glucose levels were not different between groups at rest (3.88 +/- 0.19 mM) or EE (4.32 +/- 0.35 mM). During HE, trained animals maintained blood glucose better (3.41 +/- 0.34 mM) than did untrained animals (3.03 +/- 0.42 mM). Respiratory exchange ratio (R) increased from rest (0.79 +/- 0.05) to exercise and was significantly lower in trained than in untrained animals during HE (0.87 +/- 0.02 vs. 0.93 +/- 0.03). Glucose turnover (Rt) calculated from [3H]glucose was not different between groups at rest (46.2 +/- 2.7 mumol x kg-1 x min-1). Turnover increased during EE to 91.5 +/- 7.5 vs. 72 +/- 8.5 mumol x kg-1 x min-1 in untrained and trained animals, respectively. During HE, Rt rose to 95.0 +/- 12.6 in trained animals but fell to 78.7 +/- 9.9 mumol x kg-1 x min-1 in untrained animals. The percentage of glucose flux oxidized increased from rest (44.0 +/- 6.8%) to exercise and was significantly lower in trained (73.7 +/- 4.3%) than in untrained animals (95.1 +/- 3.8%) during HE. Metabolic clearance rate increased from 12.5 +/- 0.8 in Re to 29.4 +/- 6.0 ml x min-1 x kg-1 in HE but did not differ between groups. Training improved glucose homeostasis during HE by increasing the glucose flux and by reducing the fraction of the flux lost to oxidation.


2006 ◽  
Vol 31 (03) ◽  
Author(s):  
H Hager ◽  
E Giorni ◽  
A Felli ◽  
B Mora ◽  
M Hiesmayr ◽  
...  

Diabetes ◽  
2020 ◽  
Vol 69 (Supplement 1) ◽  
pp. 2167-PUB
Author(s):  
KOHEI SURUGA ◽  
TSUYOSHI TOMITA ◽  
MASAKAZU KOBAYASHI ◽  
TADAHIKO MITSUI ◽  
KAZUNARI KADOKURA

Diabetes ◽  
2020 ◽  
Vol 69 (Supplement 1) ◽  
pp. 776-P
Author(s):  
RACHEL BRANDT ◽  
MINSUN PARK ◽  
LAURIE T. QUINN ◽  
MINSEUNG CHU ◽  
YOUNGKWAN SONG ◽  
...  

Author(s):  
Hariyadi DM ◽  
Athiyah U ◽  
Hendradi E ◽  
Rosita N ◽  
Erawati T ◽  
...  

The prevention of Diabetic Mellitus (DM) and its complications is the main aim of this study, in addition to the training of lotion foot care application and the development of small scale industry. The research team delivered knowledge in the form of training on Diabetic Mellitus, healthy food, treatment and prevention of complications, and small-scale production of cosmetic products. The aim of this study was to determine the correlation between training on diabetic and lotion foot care application as preventive measures against diabetic complications on the patient's blood glucose levels in the community of residents in Banyuurip Jaya, Surabaya. It was expected from this training that the knowledge of the residents increases and people living with diabetic undergo lifestyle changes and therefore blood sugar levels can be controlled. The parameters measured in this research were blood glucose levels, the anti diabetic drug types consumed, and compliance on diabetics. This study used the data taken from 60 patients with DM over a period of one month. Questionnaires and log books was used to retrieve data and changes in blood glucose levels in diabetic patients. The results showed the demographic data of patients with type 2 diabetic of 85% female and 15% male, with the range of patients aged of 61-70 years of 46.67% and had history of diabetic (90%). The history of drugs consumed by respondents was anti diabetic drugs such as metformin (40%), glimepiride (33.37%) and insulin (6.67%). In addition, the increased knowledge of DM patients after being given the training compared to before training was shown in several questions in the questionnaire. A statistical analysis using t-test analyzed a correlation between training provided in order to enhance understanding of the patient, as well as correlation with blood glucose levels. A paired T-test showed that there was a relationship between the knowledge of trainees before and after training (p less than 0.05). An interesting result was that there was no relationship between blood glucose levels before and after training provided (p> 0.05).


MEDISAINS ◽  
2020 ◽  
Vol 18 (1) ◽  
pp. 19
Author(s):  
Fairuz Fairuz ◽  
Hasna Dewi ◽  
Humaryanto Humaryanto

Background: Therapies for hyperglycemic treatment, including insulin and oral diabetes medications, have been confirmed to cause several side effects. Thus, finding new drugs with fewer side effects is of high importance. Salung leaf herb (Psychotria malayana Jack) reported used in traditional societies as a treatment for diabetes. However, the scientific proof of this plant for diabetes treatment is still lacking.Objective: To evaluate the antidiabetic effect of the P. malayana jack in induced type 1 diabetic rats by assessing blood glucose level and pancreatic cells in white rats.Methods: Alloxan used to induce type I diabetes. Rats randomly divided into six groups. A Group P1 received 250 mg/kg BW; group P2 received 500 mg/kg BW, group P3 received 1000 mg/kg BW. While group 4 basal received no treatment, group 5 received distilled water as a negative control, and group 6 received glibenclamide as a positive control. Medications are given for six days. Glucose levels were measured, and observation of pancreatic Langerhans cell damages.Results:  A decrease in blood glucose levels observed in all treatment groups. The most significant reduction (49.76%; 1000 mg/kg BW) occurred in the P3 group. Morphological features of pancreatic Langerhans cell damage were slightly high in the P1 group.Conclusion: P. malayana Jack can consider having an antidiabetic effect in a type 1 diabetic rat by reducing blood glucose levels.


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