A preliminary study on relations between structure and function of dystrophic muscles

1984 ◽  
Vol 86 (3) ◽  
pp. 230
Author(s):  
H. Janssen ◽  
W. Wallinga-de Jonge ◽  
P. Wirtz ◽  
P. de Jong ◽  
J. Broenink ◽  
...  
2000 ◽  
Vol 10 (2) ◽  
pp. 295-315 ◽  
Author(s):  
David Trevarthen

The cairns at Balnuaran of Clava show a structural relationship to the annual cycle, most clearly in their alignment on Midwinter sunset. The stones used in their construction fall into simple colour classes: ‘red’, ‘white’ and ‘black’. All three, but especially the black, appear to show selective arrangement in the cairns. A preliminary study of the relationships between the position of coloured stones and certain solar alignments, using both direct opposition and shadow casting, indicates that choice of colour may have been a significant factor in the positioning of stones within the monuments. Moreover the three colours seem to show a consistent pattern of meaning across a wide spectrum of cultures, which may imply a universal psychological factor in their symbolic use.


2008 ◽  
Vol 23 (4) ◽  
pp. 224-229 ◽  
Author(s):  
Katarzyna Mizia-Stec ◽  
Zbigniew Gąsior ◽  
Barbara Zahorska-Markiewicz ◽  
Michał Holecki ◽  
Maciej Haberka ◽  
...  

2010 ◽  
Vol 5 (1) ◽  
pp. 65-75 ◽  
Author(s):  
Joshua L. Roffman ◽  
David G. Brohawn ◽  
Jesse S. Friedman ◽  
Kara A. Dyckman ◽  
Katharine N. Thakkar ◽  
...  

Metabolites ◽  
2020 ◽  
Vol 10 (5) ◽  
pp. 191 ◽  
Author(s):  
Agata Światły-Błaszkiewicz ◽  
Lucyna Mrówczyńska ◽  
Eliza Matuszewska ◽  
Jan Lubawy ◽  
Arkadiusz Urbański ◽  
...  

Red blood cells (RBCs) are the most abundant cells in the human blood that have been extensively studied under morphology, ultrastructure, biochemical and molecular functions. Therefore, RBCs are excellent cell models in the study of biologically active compounds like drugs and toxins on the structure and function of the cell membrane. The aim of the present study was to explore erythrocyte ghost’s proteome to identify changes occurring under the influence of three bee venom peptides-melittin, tertiapin, and apamin. We conducted preliminary experiments on the erythrocyte ghosts incubated with these peptides at their non-hemolytic concentrations. Such preparations were analyzed using liquid chromatography coupled with tandem mass spectrometry. It was found that when higher concentrations of melittin and apamin were used, fewer proteins were identified. Moreover, the results clearly indicated that apamin demonstrates the greatest influence on the RBCs ghosts proteome. Interestingly, the data also suggest that tertiapin exerted a stabilizing effect on the erythrocyte membrane. The experiments carried out show the great potential of proteomic research in the projects focused on the toxin’s properties as membrane active agents. However, to determine the specificity of the effect of selected bee venom peptides on the erythrocyte ghosts, further proteomic research should be focused on the quantitative analysis.


2020 ◽  
Vol 35 (3-4) ◽  
pp. 169-176
Author(s):  
Agnieszka Kraszewska ◽  
Ewa Ferensztajn-Rochowiak ◽  
Janusz Rybakowski

Aims: Long-term treatment with lithium in patients with bipolar disorder (BD) exerts a significant effect on thyroid structure and function. Previously, it was found that adding to lithium other mood stabilising or antidepressant drugs can also be important. The aim of this preliminary study was to compare thyroid structure and function in patients with BD receiving long-term lithium monotherapy with monotherapy using other mood stabilising drugs, such as carbamazepine, valproates or quetiapine. Method: Forty-one BD patients were studied (13 male, 28 female) aged 28–80 years. In 15, monotherapy with lithium was given; in 10 – with carbamazepine; and in 8 – with valproate and quetiapine. In all patients, the thyroid-stimulating hormone (TSH), free thyroxine (fT3) free triiodothyronine (fT4), and the antibodies against thyroid peroxidase (TPOAb), thyroglobulin (TGAb) and TSH receptors (TSHRAb) were estimated. Goiter was diagnosed when the thyroid volume exceeded 18 cm3 in women and 25 cm3 in men. Results: The groups were of similar age; however, the duration of quetiapine therapy was shorter than lithium or carbamazepine. Comparing to patients on lithium monotherapy, the median of TSH concentration was lower in patients on quetiapine, and the median of TPOAB lower in patients on valproates. The highest frequency of goiter (47%) was observed in patients receiving lithium. Conclusions: The results obtained may suggest that among the studied mood stabilisers, lithium exerts the biggest goiter-inducing effect. The differences between groups as to thyroid hormones and antibodies were not significant. The limitation of the study was a small number of studied patients.


2008 ◽  
Vol 2 (1) ◽  
pp. 49-58 ◽  
Author(s):  
Donna L. Seckfort ◽  
Robert Paul ◽  
Stuart M. Grieve ◽  
Brian Vandenberg ◽  
Richard A. Bryant ◽  
...  

Koedoe ◽  
1991 ◽  
Vol 34 (1) ◽  
Author(s):  
V. Watson

Fossil bird bones from the Swartkrans cave estimated at about one million years old have been identified to family level. Differences in humerus and sternum structure were noted. This led to an investigation into flight styles and behaviour as well as the muscle structure and function of the modern representatives of three families (Phasianidae - francolins; Columbidae - pigeons; Tytonidae - barn and grass owls) in an attempt to understand why the bones in these families were so distinctive.


2015 ◽  
Vol 23 ◽  
pp. A124
Author(s):  
J.E. Beveridge ◽  
G.B. Sharma ◽  
G. Kuntze ◽  
J.L. Jaremko ◽  
S. Koles ◽  
...  

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