Illuminating the Monuments: Observation and Speculation on the Structure and Function of the Cairns at Balnuaran of Clava

2000 ◽  
Vol 10 (2) ◽  
pp. 295-315 ◽  
Author(s):  
David Trevarthen

The cairns at Balnuaran of Clava show a structural relationship to the annual cycle, most clearly in their alignment on Midwinter sunset. The stones used in their construction fall into simple colour classes: ‘red’, ‘white’ and ‘black’. All three, but especially the black, appear to show selective arrangement in the cairns. A preliminary study of the relationships between the position of coloured stones and certain solar alignments, using both direct opposition and shadow casting, indicates that choice of colour may have been a significant factor in the positioning of stones within the monuments. Moreover the three colours seem to show a consistent pattern of meaning across a wide spectrum of cultures, which may imply a universal psychological factor in their symbolic use.

2008 ◽  
Vol 23 (4) ◽  
pp. 224-229 ◽  
Author(s):  
Katarzyna Mizia-Stec ◽  
Zbigniew Gąsior ◽  
Barbara Zahorska-Markiewicz ◽  
Michał Holecki ◽  
Maciej Haberka ◽  
...  

2010 ◽  
Vol 5 (1) ◽  
pp. 65-75 ◽  
Author(s):  
Joshua L. Roffman ◽  
David G. Brohawn ◽  
Jesse S. Friedman ◽  
Kara A. Dyckman ◽  
Katharine N. Thakkar ◽  
...  

1984 ◽  
Vol 86 (3) ◽  
pp. 230
Author(s):  
H. Janssen ◽  
W. Wallinga-de Jonge ◽  
P. Wirtz ◽  
P. de Jong ◽  
J. Broenink ◽  
...  

Metabolites ◽  
2020 ◽  
Vol 10 (5) ◽  
pp. 191 ◽  
Author(s):  
Agata Światły-Błaszkiewicz ◽  
Lucyna Mrówczyńska ◽  
Eliza Matuszewska ◽  
Jan Lubawy ◽  
Arkadiusz Urbański ◽  
...  

Red blood cells (RBCs) are the most abundant cells in the human blood that have been extensively studied under morphology, ultrastructure, biochemical and molecular functions. Therefore, RBCs are excellent cell models in the study of biologically active compounds like drugs and toxins on the structure and function of the cell membrane. The aim of the present study was to explore erythrocyte ghost’s proteome to identify changes occurring under the influence of three bee venom peptides-melittin, tertiapin, and apamin. We conducted preliminary experiments on the erythrocyte ghosts incubated with these peptides at their non-hemolytic concentrations. Such preparations were analyzed using liquid chromatography coupled with tandem mass spectrometry. It was found that when higher concentrations of melittin and apamin were used, fewer proteins were identified. Moreover, the results clearly indicated that apamin demonstrates the greatest influence on the RBCs ghosts proteome. Interestingly, the data also suggest that tertiapin exerted a stabilizing effect on the erythrocyte membrane. The experiments carried out show the great potential of proteomic research in the projects focused on the toxin’s properties as membrane active agents. However, to determine the specificity of the effect of selected bee venom peptides on the erythrocyte ghosts, further proteomic research should be focused on the quantitative analysis.


Author(s):  
Jiorgos Kourelis ◽  
Sophien Kamoun

ABSTRACTReference datasets are critical in computational biology. They help define canonical biological features and are essential for benchmarking studies. Here, we describe a comprehensive reference dataset of experimentally validated plant NLR immune receptors. RefPlantNLR consists of 415 NLRs from 31 genera belonging to 11 orders of flowering plants. We used RefPlantNLR to determine the canonical features of functionally validated plant NLRs. This reference dataset should prove useful for benchmarking NLR annotation tools, guiding comparative analyses of NLRs across the wide spectrum of plant diversity and identifying under-studied taxa. We hope that the RefPlantNLR resource will contribute to moving the field beyond a uniform view of NLR structure and function.


Author(s):  
Stergios Doumouchtsis

This chapter provides up-to-date information on a series of subjects covering a wide spectrum of basic sciences and selected topics with relevance to various clinical practice areas in obstetrics and gynaecology. It is not possible to provide a completely comprehensive cover of all areas of basic sciences within a book chapter, but the subjects explored here include the structure and function of the genome ovulation and ovarian function, fertilization and implantation, embryology, pathology, microbiology, immunology, biochemistry, physiology, endocrinology, pharmacology, and physics (including imaging techniques). Some of these topics are discussed in more detail in other chapters in this textbook. Key knowledge is presented using simple and concise definitions for quick reference along with tables and diagrams.


2020 ◽  
Vol 35 (3-4) ◽  
pp. 169-176
Author(s):  
Agnieszka Kraszewska ◽  
Ewa Ferensztajn-Rochowiak ◽  
Janusz Rybakowski

Aims: Long-term treatment with lithium in patients with bipolar disorder (BD) exerts a significant effect on thyroid structure and function. Previously, it was found that adding to lithium other mood stabilising or antidepressant drugs can also be important. The aim of this preliminary study was to compare thyroid structure and function in patients with BD receiving long-term lithium monotherapy with monotherapy using other mood stabilising drugs, such as carbamazepine, valproates or quetiapine. Method: Forty-one BD patients were studied (13 male, 28 female) aged 28–80 years. In 15, monotherapy with lithium was given; in 10 – with carbamazepine; and in 8 – with valproate and quetiapine. In all patients, the thyroid-stimulating hormone (TSH), free thyroxine (fT3) free triiodothyronine (fT4), and the antibodies against thyroid peroxidase (TPOAb), thyroglobulin (TGAb) and TSH receptors (TSHRAb) were estimated. Goiter was diagnosed when the thyroid volume exceeded 18 cm3 in women and 25 cm3 in men. Results: The groups were of similar age; however, the duration of quetiapine therapy was shorter than lithium or carbamazepine. Comparing to patients on lithium monotherapy, the median of TSH concentration was lower in patients on quetiapine, and the median of TPOAB lower in patients on valproates. The highest frequency of goiter (47%) was observed in patients receiving lithium. Conclusions: The results obtained may suggest that among the studied mood stabilisers, lithium exerts the biggest goiter-inducing effect. The differences between groups as to thyroid hormones and antibodies were not significant. The limitation of the study was a small number of studied patients.


2021 ◽  
Vol 22 (2) ◽  
pp. 897
Author(s):  
Matúš Čoma ◽  
Lucia Fröhlichová ◽  
Lukáš Urban ◽  
Robert Zajíček ◽  
Tomáš Urban ◽  
...  

Excessive connective tissue accumulation, a hallmark of hypertrophic scaring, results in progressive deterioration of the structure and function of organs. It can also be seen during tumor growth and other fibroproliferative disorders. These processes result from a wide spectrum of cross-talks between mesenchymal, epithelial and inflammatory/immune cells that have not yet been fully understood. In the present review, we aimed to describe the molecular features of fibroblasts and their interactions with immune and epithelial cells and extracellular matrix. We also compared different types of fibroblasts and their roles in skin repair and regeneration following burn injury. In summary, here we briefly review molecular changes underlying hypertrophic scarring following burns throughout all basic wound healing stages, i.e. during inflammation, proliferation and maturation.


Sign in / Sign up

Export Citation Format

Share Document