The failed-back syndrome: pathophysiology and clinical features of an iatrogenic pain syndrome

Abstract About 65% of multiple sclerosis (MS) patients experience a broad range of both acute and subacute painful syndromes. Acute conditions (eg, trigeminal neuralgia and Lhermitte's syndrome) cause intense, unrelenting pain that may worsen with age and disease progression. Chronic pain (eg, joint pain) is also a component of MS. Pain syndromes, including optic neuritis, complex regional pain syndrome (CRPS), and other less well-known syndromes, may respond to a variety of pharmacologic, surgical, or alternative interventions. MS patients may also experience iatrogenic pain. Some successful drug treatments for pain that are used in combination or alone include anticonvulsants, tricyclics, methylprednisolone, and narcotics. Surgical interventions, percutaneous compression-balloons, and radiofrequency ablation are other viable options for some pain syndromes.

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Neuropsychological and Related Clinical Features Associated with Complex Regional Pain Syndrome: A Latent Class Analysis

British Journal of Medicine and Medical Research ◽

10.9734/bjmmr/2016/29713 ◽

2016 ◽

Vol 18 (12) ◽

pp. 1-12

Author(s):

David Libon ◽

Joel Eppig ◽

Deborah Drabick ◽

Kirsten Erwin ◽

Christine Annibali ◽

...

Keyword(s):

Latent Class Analysis ◽

Complex Regional Pain Syndrome ◽

Clinical Features ◽

Latent Class ◽

Pain Syndrome ◽

Class Analysis

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Familial Occurrence of Complex Regional Pain Syndrome

Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques ◽

10.1017/s0317167100010301 ◽

2010 ◽

Vol 37 (3) ◽

pp. 389-394 ◽

Cited By ~ 12

Author(s):

Peyman Shirani ◽

Ali Jawaid ◽

Paolo Moretti ◽

Elham Lahijani ◽

Alicia R. Salamone ◽

...

Keyword(s):

Complex Regional Pain Syndrome ◽

Clinical Features ◽

Genetic Basis ◽

Genetic Factors ◽

Age At Onset ◽

Pain Syndrome ◽

Case Histories ◽

Younger Age ◽

History Of ◽

Pain Symptoms

Background:The etiology of complex regional pain syndrome (CRPS) is unknown. Different environmental and genetic factors have been postulated to contribute to CRPS.Methods:We reviewed the clinical data from a cohort of 69 patients with CRPS. Four families were identified with two or more members affected with CRPS yielding a total of nine patients. Six more patients reported the presence of pain symptoms in their family members, however; this could not be clinically confirmed.Results:The case histories of the nine individuals with ‘familial’ CRPS suggested a younger age at onset and more frequent history of migraine versus the non-familial patients. A pattern of inheritance could not be ascertained.Conclusion:This data supports the hypothesis that CRPS can be familial and hence may have a genetic basis in some families. Larger studies will be needed to ascertain clearer patterns of inheritance and to determine whether the clinical features of ‘familial’ CRPS are the same as the sporadic form.

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Efficiency and safety of opioid therapy of chronic pain syndrome in patients with cancer of the refractory iron: clinico-pathogenetic features

Experimental and Clinical Gastroenterology ◽

10.31146/1682-8658-ecg-170-10-45-51 ◽

2020 ◽

Vol 1 (10) ◽

pp. 45-51

Author(s):

O. P. Bobrova ◽

N. A. Schneider ◽

M. M. Petrova ◽

D. V. Dmitrenko ◽

S. K. Zyryanov ◽

...

Keyword(s):

Pancreatic Cancer ◽

Chronic Pain ◽

Clinical Features ◽

Pain Syndrome ◽

Opioid Therapy ◽

Chronic Pain Syndrome ◽

Efficacy And Safety ◽

Patients With Cancer ◽

Analgesic Therapy ◽

Comparison Groups

Aim. To study the influence of clinical and pathogenetic factors in patients with pancreatic cancer on the efficacy and safety of analgesic therapy of chronic pain syndrome.Materials and methods. Clinical features of formation of chronic pain syndrome predetermining the efficacy and safety of analgesic therapy were studied in 82 patients with pancreatic cancer.Results. The efficacy and safety of opioids in the comparison groups of morphine sulfate, fentanyl TTC and oxycodone / naloxone in patients with pancreatic cancer was shown.

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