Immunohistochemical distribution of somatostatin-like immunoreactivity in the central nervous system of the adult rat

Neuroscience ◽  
1984 ◽  
Vol 13 (2) ◽  
pp. 265-IN2 ◽  
Author(s):  
O. Johansson ◽  
T. Hökfelt ◽  
R.P. Elde
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Adult Rat ◽  
The Central Nervous System

Immunohistochemical localization of the voltage-gated potassium channel subunit Kv1.4 in the central nervous system of the adult rat

2003 ◽  
Vol 26 (3) ◽  
pp. 209-224 ◽  
Author(s):  
Rafael Luján ◽  
Carlos de Cabo de la Vega ◽  
Eduardo Dominguez del Toro ◽  
Juan J Ballesta ◽  
Manuel Criado ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Potassium Channel ◽  
Immunohistochemical Localization ◽  
Voltage Gated ◽  
Adult Rat ◽  
The Central Nervous System

3-Methylbutanal Metabolism in the Adult Rat

1981 ◽  
Vol 61 (4) ◽  
pp. 451-455 ◽  
Author(s):  
S. Kubow ◽  
G. H. Anderson ◽  
L. M. Blendis ◽  
E. Goldberg
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Hepatic Encephalopathy ◽  
Normal Component ◽  
Rat Plasma ◽  
Adult Rats ◽  
Adult Rat ◽  
The Central Nervous System ◽  
Nervous System Function ◽  
Normal Constituent

1. 3-Methylbutanal is a normal constituent of human plasma and is elevated in patients with hepatic encephalopathy. Therefore these studies examined the possible source and site of synthesis of 3-methylbutanal and its effect on the central nervous system of adult rats. 2. 3-Methylbutanal was found to be a normal constituent of rat plasma and increased two to five times when leucine comprised 5% of the diet. Neomycin in the diet prevented the leucine-induced rise in plasma 3-methylbutanal. When this was injected at a dose of 120 mg/kg abnormal EEG patterns and sleep-like behaviour occurred, whereas smaller amounts (30 mg/kg) increased brain serotonin concentrations. 3. 3-Methylbutanal is a normal component of rat plasma: it may be derived in part from colonic bacterial breakdown of leucine and may influence central nervous system function. A possible relationship of 3-methylbutanal to the pathogenesis of hepatic encephalopathy is suggested.

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