Differential response of plasma glucose, amino acids and nonesterified fatty acids to insulin in depressed patients

1984 ◽  
Vol 9 (2) ◽  
pp. 161-171 ◽  
Author(s):  
M MENNAPERPER ◽  
J ROCHFORD ◽  
P MUELLER ◽  
M SWARTZBURG ◽  
A JEKELIS ◽  
...  
Keyword(s):  
Amino Acids ◽  
Fatty Acids ◽  
Plasma Glucose ◽  
Differential Response ◽  
Nonesterified Fatty Acids ◽  
Depressed Patients

Mechanism, temporal patterns, and magnitudes of the metabolic responses to the KATP channel agonist diazoxide

2005 ◽  
Vol 288 (1) ◽  
pp. E80-E85 ◽  
Author(s):  
Bharathi Raju ◽  
Philip E. Cryer
Keyword(s):  
Fatty Acids ◽  
Insulin Secretion ◽  
Fatty Acid ◽  
Plasma Glucose ◽  
Plasma Insulin ◽  
Temporal Patterns ◽  
Metabolic Responses ◽  
Nonesterified Fatty Acid ◽  
Nonesterified Fatty Acids ◽  
C Peptide

To assess the mechanism, temporal patterns, and magnitudes of the metabolic responses to the ATP-dependent potassium channel agonist diazoxide, neuroendocrine and metabolic responses to intravenous diazoxide (saline, 1.0 and 2.0 mg/kg) and oral diazoxide (placebo, 4.0 and 6.0 mg/kg) were assessed in healthy young adults. Intravenous diazoxide produced rapid, but transient, decrements ( P = 0.0023) in plasma insulin (e.g., nadirs of 2.8 ± 0.5 and 1.8 ± 0.3 μU/ml compared with 7.0 ± 1.0 μU/ml after saline at 4.0–7.5 min) and C-peptide ( P = 0.0228) associated with dose-related increments in plasma glucose ( P = 0.0044) and serum nonesterified fatty acids ( P < 0.0001). After oral diazoxide, plasma insulin appeared to decline, as did C-peptide, again associated with dose-related increments in plasma glucose ( P < 0.0001) and serum nonesterified fatty acids ( P = 0.0141). Plasma glucagon, as well as cortisol and growth hormone, was not altered. Plasma epinephrine increased ( P = 0.0215) slightly only after intravenous diazoxide. There were dose-related increments in plasma norepinephrine ( P = 0.0038 and P = 0.0005, respectively), undoubtedly reflecting a compensatory sympathetic neural response to vasodilation produced by diazoxide, but these would not raise plasma glucose or serum nonesterified fatty acid levels. Thus selective suppression of insulin secretion, without stimulation of glucagon secretion, raised plasma glucose and serum nonesterified fatty acid concentrations. These findings define the temporal patterns and magnitudes of the metabolic responses to diazoxide and underscore the primacy of regulated insulin secretion in the physiological regulation of postabsorptive carbohydrate and lipid metabolism.

EFFECTS OF DIET ON PLASMA GLUCOSE, FREE FATTY ACIDS, AND AMINO ACIDS DURING AN ULTRAMARATHON 179

1996 ◽  
Vol 28 (Supplement) ◽  
pp. 30
Author(s):  
S. P. Bailey ◽  
H. S. Case ◽  
D. E. Miller ◽  
D. Evans
Keyword(s):  
Amino Acids ◽  
Fatty Acids ◽  
Free Fatty Acids ◽  
Plasma Glucose

scholarly journals Responses of plasma glucose and nonesterified fatty acids to intravenous insulin tolerance tests in dairy cows during a 670-day lactation

2017 ◽  
Vol 100 (4) ◽  
pp. 3272-3281 ◽  
Author(s):  
L.C. Marett ◽  
M.J. Auldist ◽  
W.J. Wales ◽  
K.L. Macmillan ◽  
F.R. Dunshea ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Dairy Cows ◽  
Plasma Glucose ◽  
Nonesterified Fatty Acids ◽  
Intravenous Insulin ◽  
Insulin Tolerance

scholarly journals Plasma glucose and nonesterified fatty acids response to epinephrine challenges in dairy cows during a 670-d lactation

2018 ◽  
Vol 101 (4) ◽  
pp. 3501-3513 ◽  
Author(s):  
L.C. Marett ◽  
M.J. Auldist ◽  
W.J. Wales ◽  
K.L. Macmillan ◽  
F.R. Dunshea ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Dairy Cows ◽  
Plasma Glucose ◽  
Nonesterified Fatty Acids

1010-P: Effects of MEDI0382, an Oxyntomodulin-Like Peptide with Targeted GLP-1/Glucagon Receptor Activity, on Amino Acids, Ketones, and Free Fatty Acids

Diabetes ◽  
2019 ◽  
Vol 68 (Supplement 1) ◽  
pp. 1010-P
Author(s):  
VICTORIA E. PARKER ◽  
DARREN ROBERTSON ◽  
TAO WANG ◽  
DAVID C. HORNIGOLD ◽  
MAXIMILIAN G. POSCH ◽  
...  
Keyword(s):  
Amino Acids ◽  
Fatty Acids ◽  
Free Fatty Acids ◽  
Receptor Activity ◽  
Glucagon Receptor
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