31 Apoptosis and radiation clonogenic survival in a solid tumor model system expressing BCL-2

1995 ◽  
Vol 32 ◽  
pp. 156
Author(s):  
Marc S. Rudoltz ◽  
Eric J. Bernhard ◽  
Gary D. Kao ◽  
Vincent Baukanauskas ◽  
Ruth J. Muschel ◽  
...  
Keyword(s):  
Solid Tumor ◽  
Tumor Model ◽  
Clonogenic Survival ◽  
Model System ◽  
Tumor Model System ◽  
Solid Tumor Model

scholarly journals Tracing tumorigenesis in a solid tumor model at single-cell resolution

2020 ◽  
Vol 11 (1) ◽  
Author(s):  
Samantha D. Praktiknjo ◽  
Benedikt Obermayer ◽  
Qionghua Zhu ◽  
Liang Fang ◽  
Haiyue Liu ◽  
...  
Keyword(s):  
Single Cell ◽  
Solid Tumor ◽  
Tumor Model ◽  
Solid Tumor Model

scholarly journals Penetration and Silencing Activity of VEGF Dicer Substrate siRNA Vectorized by Chitosan Nanoparticles in Monolayer Culture and a Solid Tumor ModelIn Vitrofor Potential Application in Tumor Therapy

2016 ◽  
Vol 2016 ◽  
pp. 1-16 ◽  
Author(s):  
Maria Abdul Ghafoor Raja ◽  
Haliza Katas ◽  
Zariyantey Abd Hamid
Keyword(s):  
Solid Tumor ◽  
Monolayer Culture ◽  
Tumor Therapy ◽  
Chitosan Nanoparticles ◽  
Tumor Model ◽  
Tumor Growth Inhibition ◽  
Knock Down ◽  
Human Solid Tumors ◽  
Solid Tumor Model

Penetration and distribution of drug through the avascular regions of human solid tumors after extravasation are crucial concerns for antitumor efficacy. To address this issue, anin vitrosolid tumor model of multicellular layers (MCLs) of human colorectal cancer cells (DLD-1) was established. In an attempt to deliver Dicer substrate small interfering RNA (DsiRNA), chitosan (CS) nanoparticles have been developed for targeting vascular endothelial growth factor (VEGF) gene for tumor growth inhibition. The DsiRNA-CS nanoparticles prepared by ionic gelation method had provided maximal protection of DsiRNA in full human serum up to 48 h incubation. RT-PCR studies revealed significant concentration- and time-dependent knock-down ofVEGFmRNA and its product due to uniform penetration of DsiRNA-CS nanoparticles throughout MCLs. Taken together, this study also demonstrated that DsiRNA-CS nanoparticles could effectively knock downVEGFgene as therapeutic target in monolayer culture or in solid tumor model for potential treatment of human colorectal carcinoma.

The rat bladder tumor model system RBT resembles phenotypically and cytogenetically human superficial transitional cell carcinoma

1993 ◽  
Vol 21 (6) ◽  
pp. 413-421 ◽  
Author(s):  
R. J. A. van Moorselaar ◽  
T. Ichikawa ◽  
H. E. Schaafsma ◽  
P. H. K. Jap ◽  
J. T. Isaacs ◽  
...  
Keyword(s):  
Transitional Cell Carcinoma ◽  
Cell Carcinoma ◽  
Bladder Tumor ◽  
Transitional Cell ◽  
Tumor Model ◽  
Model System ◽  
Rat Bladder ◽  
Tumor Model System

Growth and Chemotherapeutic Response of Cells in a Hollow-Fiber In Vitro Solid Tumor Model

1994 ◽  
Vol 86 (24) ◽  
pp. 1846-1852 ◽  
Author(s):  
J. J. Casciari ◽  
M. G. Hollingshead ◽  
M. C. Alley ◽  
J. G. Mayo ◽  
L. Malspeis ◽  
...  
Keyword(s):  
Solid Tumor ◽  
Hollow Fiber ◽  
Tumor Model ◽  
Chemotherapeutic Response ◽  
Solid Tumor Model

Antitumorigenic Potential of Linalool Is Accompanied by Modulation of Oxidative Stress: An In Vivo Study in Sarcoma-180 Solid Tumor Model

2014 ◽  
Vol 66 (5) ◽  
pp. 835-848 ◽  
Author(s):  
Samarjit Jana ◽  
Kartick Patra ◽  
Shehnaz Sarkar ◽  
Jagannath Jana ◽  
Gopeswar Mukherjee ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Solid Tumor ◽  
Tumor Model ◽  
In Vivo Study ◽  
Sarcoma 180 ◽  
Solid Tumor Model

scholarly journals Head-To-Head Comparison of Biological Behavior of Biocompatible Polymers Poly(Ethylene Oxide), Poly(2-Ethyl-2-Oxazoline) and Poly[N-(2-Hydroxypropyl)Methacrylamide] as Coating Materials for Hydroxyapatite Nanoparticles in Animal Solid Tumor Model

Nanomaterials ◽  
2020 ◽  
Vol 10 (9) ◽  
pp. 1690
Author(s):  
Zbynek Novy ◽  
Volodymyr Lobaz ◽  
Martin Vlk ◽  
Jan Kozempel ◽  
Petr Stepanek ◽  
...  
Keyword(s):  
Ethylene Oxide ◽  
Solid Tumor ◽  
Tumor Model ◽  
Biological Behavior ◽  
Coating Materials ◽  
Hydroxypropyl Methacrylamide ◽  
Poly Ethylene Oxide ◽  
Poly Ethylene ◽  
Tumor Accumulation ◽  
Solid Tumor Model

Nanoparticles (NPs) represent an emerging platform for diagnosis and treatment of various diseases such as cancer, where they can take advantage of enhanced permeability and retention (EPR) effect for solid tumor accumulation. To improve their colloidal stability, prolong their blood circulation time and avoid premature entrapment into reticuloendothelial system, coating with hydrophilic biocompatible polymers is often essential. Most studies, however, employ just one type of coating polymer. The main purpose of this study is to head-to-head compare biological behavior of three leading polymers commonly used as “stealth” coating materials for biocompatibilization of NPs poly(ethylene oxide), poly(2-ethyl-2-oxazoline) and poly[N-(2-hydroxypropyl)methacrylamide] in an in vivo animal solid tumor model. We used radiolabeled biodegradable hydroxyapatite NPs as a model nanoparticle core within this study and we anchored the polymers to the NPs core by hydroxybisphosphonate end groups. The general suitability of polymers for coating of NPs intended for solid tumor accumulation is that poly(2-ethyl-2-oxazoline) and poly(ethylene oxide) gave comparably similar very good results, while poly[N-(2-hydroxypropyl)methacrylamide] was significantly worse. We did not observe a strong effect of molecular weight of the coating polymers on tumor and organ accumulation, blood circulation time, biodistribution and biodegradation of the NPs.

Antitumor Effects of Bacillus Calmette- Guerin in a Syngeneic Rat Bladder Tumor Model System, RBT323

1993 ◽  
Vol 149 (1) ◽  
pp. 179-182 ◽  
Author(s):  
E.B. Cornel ◽  
R.J.A. Van Moorselaar ◽  
P. Van Stratum ◽  
F.M.J. Debruyne ◽  
J.A. Schalken
Keyword(s):  
Bladder Tumor ◽  
Tumor Model ◽  
Model System ◽  
Bacillus Calmette Guerin ◽  
Antitumor Effects ◽  
Rat Bladder ◽  
Tumor Model System
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