Peripheral self-tolerance and autoimmunity: the protective role of expression of class II major histocompatibility antigens on non-lymphoid cells

1989 ◽  
Vol 43 (8) ◽  
pp. 593-605 ◽  
Author(s):  
Y. Iwatani ◽  
N. Amino ◽  
K. Miyai
Keyword(s):  
Class Ii ◽  
Protective Role ◽  
Lymphoid Cells ◽  
Major Histocompatibility ◽  
Histocompatibility Antigens ◽  
Self Tolerance ◽  
Major Histocompatibility Antigens

Antigen-induced suppression: The role of Class I major histocompatibility antigens

1985 ◽  
Vol 5 (10-11) ◽  
pp. 1007-1014 ◽  
Author(s):  
Kathryn J. Wood ◽  
Peter J. Morris
Keyword(s):  
Class I ◽  
Major Histocompatibility ◽  
Rat Erythrocytes ◽  
Histocompatibility Antigens ◽  
Class I Mhc ◽  
Specific Suppression ◽  
Mhc Antigens ◽  
Beneficial Effects ◽  
Major Histocompatibility Antigens

The role of Class I major histocompatibility (MHC) antigens in the induction of specific suppression of graft rejection has been investigated. Two experimental transplantation models have been used ’ fully vascularized heterotopic Cardiac altografts in the mouse and fully vascularized orthotopic renal allografts in the rat. Preparations of ceils expressing Class I MHC antigens, for example highly purified preparations of rat erythrocytes or platelets or mouse L cells (H2k) transfected with the D locus Class I gene of the b haplotype, LDb-1 cells, were used to pretreat recipients prior to transplantation, The function of the allograft was monitored in order to assess any beneficial effects induced by Class I MHC antigens. The results obtained implicate Class I MHC as important in the induction of specific immunosuppression of vascularized allograft rejection.

INDUCTION OF CLASS II MAJOR HISTOCOMPATIBILITY ANTIGENS ON THYROID, ADULT PANCREATIC ISLET, AND FETAL PROISLET ALLOGRAFTS

1992 ◽  
Vol 53 (4) ◽  
pp. 834-839 ◽  
Author(s):  
HILARY S. WARREN ◽  
MICHELLE J. HODDER ◽  
WILLIAM ALLAN ◽  
DAVID A. HUME ◽  
CHARMAINE J. SIMEONOVIC
Keyword(s):  
Pancreatic Islet ◽  
Class Ii ◽  
Major Histocompatibility ◽  
Histocompatibility Antigens ◽  
Major Histocompatibility Antigens
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