Sperm surface antigens involved in mammalian fertilization: their role in contraceptive vaccine development for humans

1990 ◽  
Vol 2 (5) ◽  
pp. 748-751 ◽  
Author(s):  
R.K. Naz
Keyword(s):  
Vaccine Development ◽  
Surface Antigens ◽  
Sperm Surface ◽  
Contraceptive Vaccine ◽  
Mammalian Fertilization

Sperm surface antigens and the prospects for contraceptive vaccine development

1997 ◽  
Vol 6 (2) ◽  
pp. 81-95 ◽  
Author(s):  
Barbara Saxty ◽  
John Aitken
Keyword(s):  
World Wide ◽  
Vaccine Development ◽  
Surface Antigens ◽  
World Population ◽  
Human Spermatozoon ◽  
Contraceptive Vaccine ◽  
World Population Growth ◽  
The World ◽  
Access To Contraception ◽  
Sustainable Population

It has been estimated that 500 million couples world-wide have no access to contraception and that approximately 20% of births between 1995 and 2000 will be unwanted. Such statistics have important implications for the rate of world population growth and the possibility of maintaining a sustainable population. Although political change and the empowerment of women across the world will help address these issues, it will also be important to increase the availability of contraceptives; not only the modalities that are in current use, but also novel methods that will satisfy needs that are presently unfulfilled. One such alternative could be a vaccine targeting the human spermatozoon.

Dispersal of sperm surface antigens in the plasma membranes of polyspermically fertilized sea urchin eggs

1987 ◽  
Vol 173 (2) ◽  
pp. 628-632 ◽  
Author(s):  
David Nishioka ◽  
Donald C. Porter ◽  
James S. Trimmer ◽  
Victor D. Vacquier
Keyword(s):  
Sea Urchin ◽  
Plasma Membranes ◽  
Surface Antigens ◽  
Sea Urchin Eggs ◽  
Sperm Surface

scholarly journals Visualization of anti-sperm plasma membrane IgG and Fab as a method for localization of boar sperm membrane antigens.

1982 ◽  
Vol 30 (12) ◽  
pp. 1217-1227 ◽  
Author(s):  
L D Russell ◽  
R N Peterson ◽  
T A Russell
Keyword(s):  
Plasma Membrane ◽  
Protein A ◽  
Fluorescein Isothiocyanate ◽  
Ultrastructural Localization ◽  
Surface Antigens ◽  
Ultrastructural Level ◽  
Simple Method ◽  
Sperm Surface ◽  
Sperm Plasma Membrane ◽  
Sperm Antigens

A simple method for ultrastructural localization of sperm surface antigens by direct visualization of bound antibodies is presented. Anti-sperm plasma membrane (ASPM) immunoglobulin (Ig) G, visualized in tissues treated with an osmium:ferrocyanide mixture, projected 11-13 nm from the surface and ASPM Fab fragments projected 8-10 nm from the surface. The density of IgG labeling, as subjectively estimated, corresponded to indirect immune fluorescein isothiocyanate, indirect immunoferritin, and sperm-vesicle labeling patterns. Agglutination of sperm vesicles and sperm were demonstrated and the linking antibody visualized. A second antibody on protein A directed against ASPM IgG made the immunologic tag more apparent and indicated, in disrupted sperm preparations, labeling of both sides of the plasma membrane. The method provides for easy and sensitive localization of sperm surface antigens at the ultrastructural level and is presently being used to localize specific sperm antigens.

Monoclonal antibodies to sperm surface antigens

1983 ◽  
Vol 5 ◽  
pp. 25-26
Author(s):  
Chi-Yu Gregory Lee ◽  
Eric Wong ◽  
Vincent Lum ◽  
Evelyn Low ◽  
Alan C. Menge ◽  
...  
Keyword(s):  
Monoclonal Antibodies ◽  
Surface Antigens ◽  
Sperm Surface
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