Role of prostaglandins in the behavioral changes induced by murine IL-1α in the rat

Cytokine ◽  
1989 ◽  
Vol 1 (1) ◽  
pp. 131
Keyword(s):  
2021 ◽  
Vol 229 (3) ◽  
pp. 171-177 ◽  
Author(s):  
Jana S. Aengenheister ◽  
Renée Urban ◽  
Georg Halbeisen

Abstract. Successful treatment not only depends on adhering to taking medication and attending therapy but also on behavioral changes. In two experiments (total N = 256), we investigated the hypothesis that the perceived social role of a treatment as partner (co-producer of a health-benefits) or servant (sole provider of health benefits) could promote or prevent intentions to engage in health-related behaviors. Specifically, we used headache treatment as an everyday example and found that participants were more inclined to engage in headache-reducing behaviors when painkillers were described as partners as compared to servants. Implications of these findings for the importance of anthropomorphic social perception in the clinical application are discussed.


2017 ◽  
Vol 6 (2) ◽  
pp. 33
Author(s):  
Akhmad Pandu Setiawan

Behaviorism learning theory is oriented towards results that can be measured and observed. Repetition and training used so that the desired behavior can become a habit. The expected results of the implementation of this behavioristic theory is the formation of a desired behavior. The desirable behavior gets positive reinforcement and behavior that is not appropriate awarded the negative. Evaluation or assessment based on observed behavior. In theory this learned professor was not much give a lecture, but the brief instruction is followed by examples by themselves or through simulation. The purpose of this paper is to describe the application of the theory Behavioristic and konstruktifistik in learning activities at the School of Raden Wijaya Tarbiyah Mojokerto. Behavioristic learning theory emphasizes the changes in behavior as well as a result of the interaction between stimulus and response. Learning is a process of behavioral changes as a result of the interaction between stimulus and response. A person is considered to have learned if he could show changes in behavior. Although learning theory tigkah behavior began to be abandoned century, but collaborate on this theory with cognitive learning theory and the theory of other learning is essential for creating a learning approach that is appropriate and effective, because basically there is no single theory of learning that is truly suited to creating a learning approaches and effective fit. especially with constructivism learning model. The role of the faculty in constructivist learning very demanding mastery of a broad and in-depth about the material taught. A broad and deep knowledge allow a lecturer accept different views and ideas of students and also makes it possible to indicate whether or not the idea of ​​the road. Mastery of the material allows a professor to understand all kinds of roads and the model to arrive at a solution to the problem without fixed on one model.


2002 ◽  
Vol 20 (5) ◽  
pp. 302-305 ◽  
Author(s):  
Ragi Doggweiler-Wiygul ◽  
Elizabeth Sellhorn
Keyword(s):  

2020 ◽  
Vol 68 ◽  
pp. 109521 ◽  
Author(s):  
Sayan Ghosh ◽  
Sreetama Choudhury ◽  
Olivia Chowdhury ◽  
Sudeshna Mukherjee ◽  
Ankur Das ◽  
...  

1998 ◽  
Vol 274 (6) ◽  
pp. R1687-R1703 ◽  
Author(s):  
Alan C. Spector ◽  
Steven J. St. John

The microstructure of the licking behavior of water-deprived rats presented with either water or quinine during 45-min single-bottle tests was analyzed. The chorda tympani (CT) and glossopharyngeal (GL) nerves, which innervate the taste buds of the tongue, were transected in deeply anesthetized rats to discern their contribution to the behavioral pattern of quinine drinking. Rats were presurgically habituated to the testing protocol and postsurgically tested first with water and then novel 0.2 mM quinine-HCl in a subsequent session. The substantial decrease in intake observed in sham-operated controls ( n = 16) when quinine was the stimulus was entirely a function of a decrease in lick volume and burst size (a run of licks with interlick intervals <1 s). Contrary to the intake-suppressing effects of quinine, pause duration decreased and burst number increased. Combined transection of the CT and GL ( n = 6) strikingly opposed all of these quinine-induced behavioral changes, whereas CT transection ( n = 7) was without effect and GL transection ( n = 8) had an intermediate influence. These results suggest that taste acts more on neural circuits governing burst termination as opposed to burst initiation, which, in turn, appears to be more sensitive to signals related to physiological state. These findings are discussed in terms of other known nerve transection effects on quinine responsiveness, and the implications of the microstructural results are considered with respect to probabilistic as opposed to deterministic control of licking behavior.


CNS Spectrums ◽  
2006 ◽  
Vol 11 (11) ◽  
pp. 864-877 ◽  
Author(s):  
Iliyan S. Ivanov ◽  
Kurt P. Schuiz ◽  
Robyn C. Palmero ◽  
Jeffrey H. Newcorn

ABSTRACTBehavioral patterns of addiction include compulsive drug-seeking, persistent abuse of substances despite the often dire consequences on social functioning and physical health, and the high probability of relapse even after prolonged drug-free periods.The recent focus on the biological basis of addiction has provided evidence to support the hypothesis that behavioral manifestations for addiction are influenced by biological factors, and biological factors often produce behavioral changes that can further increase risk. The current understanding of the role of the dopaminergic, glutamatergic, γ-aminobutyric acidergic, and opioid receptor systems in the pathophysiology of addiction as well as the clinical implications of these systems for new and emerging treatments will be discussed. This article will also review the pharmacologic agents used in the treatment of substance abuse disorders and presents evidence-based data for their safety, efficacy, and feasibility of use in different patient populations.


Autophagy ◽  
2009 ◽  
Vol 5 (2) ◽  
pp. 265-267 ◽  
Author(s):  
Ignacio Vega-Naredo ◽  
Cristina Tomas-Zapico ◽  
Ana Coto-Montes

Author(s):  
Mariana Canellas Benchaya ◽  
Taís de Campos Moreira ◽  
Hilda Maria Rodrigues Moleda Constant ◽  
Natália Masiero Pereira ◽  
Luana Freese ◽  
...  

Background: This study aims to identify the association between parenting styles and behavioral changes among adolescents regarding the consumption of alcohol, tobacco, cannabis, cocaine/crack. Methods: A group of ninety-nine adolescents (39 girls and 60 boys), aged 14 to 19 years (17.05 ± 1.51), who called in to a call center that provides counseling to substance users, was followed-up for 30 days. Data collection occurred between March 2009 and October 2015. The adolescents answered questions regarding parental responsiveness and demanding nature on a scale to assess parental styles and provided sociodemographic data, substance abuse consumption characteristics, and the Contemplation Ladder scale score. Results: The parental styles most reported by the adolescents were authoritative (30%) and indulgent (28%). Children who perceived their mothers as having an indulgent style and who had absent fathers presented more difficulties in making behavioral changes to avoid alcohol and cocaine/crack consumption. Conclusion: The study found that parent-child relationships were associated with a lack of change in the adolescent regarding substance use behavior, particularly the consumption of alcohol and cocaine/crack.


2015 ◽  
Vol 33 (29_suppl) ◽  
pp. 6-6
Author(s):  
Adam Sterman ◽  
Regina Hanstein ◽  
David C. Spray

6 Background: CIPN is a debilitating side effect and dose limiting toxicity of anticancer drug therapies. CIPN induces pathological changes in dorsal root ganglia (DRG), leading to increased cross-talk between sensory neurons and satellite glial cells (SGCs), specifically ATP mediated SGC-neuron signaling. We therefore investigated CIPN in mice with neuron- or glia-specific deletion of the ATP-releasing channel Pannexin 1 (Panx 1). Methods: To induce CIPN, mice were given two i.p. oxaliplatin (oxa) injections two days apart. Controls received saline (sal). We used C57Bl6 wildtype and transgenic mice with neuron- or glia-specific Panx1 deletion (NFHcre or GFAPcre:Panx1F/F) and littermate controls (Panx1F/F), 7-11 per group. Tactile sensitivity of the hindpaws was assessed prior to and every week after injections for 3 weeks using von Frey filaments. The number of paw withdrawals to 10 stimulations with each filament and pain thresholds (corresponding to filament that elicits 8/10 responses) were recorded. Overall mouse condition was assessed using Open Field Tests. Results: C57Bl6 mice developed transient tactile hypersensitivity after oxa injection, which was most prominent at day 9 and ceased at day 21. Oxa-injected mice had lower tactile thresholds (at 9 days: sal 5.5±0.3g vs. oxa 2.7±0.4g, p < 0.001) and higher response rates to filaments compared to sal-injected controls (p < 0.05), but revealed no changes in any other behavior. Mice with glia-specific Panx1 deletion did not display significant tactile hypersensitivity at any time after oxa (tactile threshold at 9 days: sal 5.5±0.3g vs. oxa 5.8±0.2g), whereas oxa induced tactile hypersensitivity did occur in mice with neuron-specific Panx1 deletion (at 9 days: sal 6±0g vs. oxa 1.3±0g, p < 0.0001) and Panx1F/F littermates (at 9 days: sal 6.0±0g vs. oxa 1.3±0.1g, p < 0.0001). Conclusions: We found that oxaliplatin induces transient CIPN, but no other behavioral changes in wildtype mice. Deletion of the ATP-releasing channel Panx1 in glia, but not in neurons, prevented CIPN development. This points to a new molecule (Panx1) and a new cell type (glia) as potential novel targets for pain therapy.


2008 ◽  
Vol 7 (S1) ◽  
Author(s):  
Georgeta Bocheva ◽  
Miroslava Varadinova ◽  
Nadka Boyadjieva
Keyword(s):  

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