Quantitative computed tomography for prediction of vertebral fracture risk

Bone ◽  
1985 ◽  
Vol 6 (1) ◽  
pp. 1-7 ◽  
Author(s):  
C.E. Cann ◽  
H.K. Genant ◽  
F.O. Kolb ◽  
B. Ettinger
Keyword(s):  
Computed Tomography ◽  
Vertebral Fracture ◽  
Fracture Risk ◽  
Quantitative Computed Tomography ◽  
Vertebral Fracture Risk

scholarly journals Type 2 Diabetes Mellitus and Vertebral Fracture Risk

2021 ◽  
Author(s):  
Fjorda Koromani ◽  
Samuel Ghatan ◽  
Mandy van Hoek ◽  
M. Carola Zillikens ◽  
Edwin H. G. Oei ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Vertebral Fracture ◽  
Fracture Risk ◽  
Vertebral Fractures ◽  
Bone Fragility ◽  
Marrow Fat ◽  
Systematic Screening ◽  
Published Evidence ◽  
Vertebral Fracture Risk

Abstract Purpose of Review The purpose of this review is to summarize the recently published evidence concerning vertebral fracture risk in individuals with diabetes mellitus. Recent Findings Vertebral fracture risk is increased in individuals with T2DM. The presence of vertebral fractures in T2DM is associated with increased non-vertebral fracture risk and mortality. TBS could be helpful to estimate vertebral fracture risk in individuals with T2DM. An increased amount of bone marrow fat has been implicated in bone fragility in T2DM. Results from two recent studies show that both teriparatide and denosumab are effective in reducing vertebral fracture risk also in individuals with T2DM. Summary Individuals with T2DM could benefit from systematic screening in the clinic for presence of vertebral fractures.

Alendronate reduced vertebral fracture risk in postmenopausal Japanese women with osteoporosis: a 3-year follow-up study

2004 ◽  
Vol 22 (5) ◽  
pp. 462-468 ◽  
Author(s):  
Kazuhiro Kushida ◽  
Masataka Shiraki ◽  
Toshitaka Nakamura ◽  
Hideaki Kishimoto ◽  
Hirotoshi Morii ◽  
...  
Keyword(s):  
Vertebral Fracture ◽  
Fracture Risk ◽  
Japanese Women ◽  
Follow Up Study ◽  
Vertebral Fracture Risk

scholarly journals Relationship between diffuse idiopathic skeletal hyperostosis and fragility vertebral fracture: a prospective study in older men

Rheumatology ◽  
2020 ◽  
Author(s):  
Anaïs Guiot ◽  
Charline Estublier ◽  
Marine Gaude ◽  
Pawel Szulc ◽  
Roland Chapurlat
Keyword(s):  
Vertebral Fracture ◽  
Fracture Risk ◽  
Diffuse Idiopathic Skeletal Hyperostosis ◽  
Older Men ◽  
Fracture Prediction ◽  
Intervertebral Space ◽  
Disc Space Narrowing ◽  
Disc Space ◽  
Vertebral Fracture Risk ◽  
A Prospective Study

Abstract Objective To analyse the risk of incident vertebral and non-vertebral fracture in men with DISH. Methods In 782 men ages 50–85 years, DISH was diagnosed using Resnick’s criteria. In men followed prospectively for 7.5 years, a radiographic incident vertebral fracture was defined by a decrease of ≥20% or ≥4mm in any vertebral height vs baseline. Self-reported incident non-vertebral fractures were confirmed by medical records. Results Men with DISH had higher BMD at the lumbar spine (P < 0.05), but not at other skeletal sites. After adjustment for confounders including disc space narrowing (DSN) and endplate irregularity, the risk of vertebral fracture was higher in men with DISH vs men without DISH [10/164 (6.1%) vs 16/597 (2.7%), P < 0.05; odds ratio (OR) 2.89 (95% CI 1.15, 7.28), P < 0.05]. DISH and low spine BMD were each associated with a higher vertebral fracture risk. The vertebral fracture risk was higher in men who had both DISH and severe DSN. DISH and endplate irregularities (EIs) were each associated with higher vertebral fracture risk. DISH, DSN and EIs define the intervertebral space dysfunction, which was associated with higher vertebral fracture risk [OR 3.99 (95% CI 1.45, 10.98), P < 0.01]. Intervertebral space dysfunction improved the vertebral fracture prediction (ΔAUC = +0.111, P < 0.05), mainly in men with higher spine BMD (>0.9 g/cm2; ΔAUC = +0.189, P < 0.001). DISH was not associated with the risk of non-vertebral fracture. Conclusion DISH is associated with higher vertebral fracture risk, independently of other risk factors. Assessment of the intervertebral space dysfunction components may improve the vertebral fracture prediction in older men.

Sex Hormone-Binding Globulin Is Associated With Markers Of Vertebral Fracture And Vertebral Fracture Risk

2018 ◽  
Vol 21 (4) ◽  
pp. 609-610
Author(s):  
Enisa Shevroja ◽  
Fjorda Koromani ◽  
Taulant Muka ◽  
Ling Oei ◽  
Carola Zillikens ◽  
...  
Keyword(s):  
Vertebral Fracture ◽  
Fracture Risk ◽  
Sex Hormone ◽  
Sex Hormone Binding Globulin ◽  
Hormone Binding ◽  
Vertebral Fracture Risk
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