Historical development of drug delivery systems: From conventional macroscale to controlled, targeted, and responsive nanoscale systems

2018 ◽  
pp. 3-41 ◽  
Author(s):  
Nedal Y. Abu-Thabit ◽  
Abdel Salam H. Makhlouf
Keyword(s):  
Drug Delivery ◽  
Historical Development ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Nanoscale Systems

Advances in DNA Nanostructure-Based Smart Drug Delivery Systems

Nano LIFE ◽  
2017 ◽  
Vol 07 (01) ◽  
pp. 1730001 ◽  
Author(s):  
Xingjie Hu ◽  
Zejun Wang ◽  
Chunhai Fan ◽  
Haiyun Song
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Water Solubility ◽  
Dna Nanotechnology ◽  
Delivery Systems ◽  
Structure Design ◽  
Dna Nanostructures ◽  
Cellular Delivery ◽  
Nanoscale Systems ◽  
Dna Nanostructure

Highly specific deoxyribonucleic acid (DNA) base-pairing not only carries genetic information, but also provides the basis for self-assembly of novel nanostructures with programmable shapes and sizes. Unlike single-stranded and double-stranded DNA, DNA nanostructures exhibit good cellular permeability. They also have characteristics of uniform size, easy functionalization, precise addressability, excellent water solubility and high biocompatibility. Due to their unique properties, these tailored molecular devices are ideal nanoscale systems for targeting cells and triggering cellular responses. Recent progress in the field of DNA nanotechnology has demonstrated effectiveness and advantages of DNA nanostructures as smart and targeted drug delivery systems or imaging agents within living organisms. In this review, we summarize the recent advances in structure design, cargo loading and cellular delivery of DNA nanocarriers, and discuss their potential in therapeutic applications.

Techniques For The Preparation of Tissue Samples Containing Injectable Polymer Microcapsules

1985 ◽  
Vol 43 ◽  
pp. 710-711
Author(s):  
G.E. Visscher ◽  
R. L. Robison ◽  
G. J. Argentieri
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Gastrocnemius Muscle ◽  
Degradation Process ◽  
Delivery Systems ◽  
Tissue Reaction ◽  
Electron Microscopic ◽  
Tissue Samples ◽  
Injectable Polymer ◽  
Microscopic Techniques

The use of various bioerodable polymers as drug delivery systems has gained considerable interest in recent years. Among some of the shapes used as delivery systems are films, rods and microcapsules. The work presented here will deal with the techniques we have utilized for the analysis of the tissue reaction to and actual biodegradation of injectable microcapsules. This work has utilized light microscopic (LM), transmission (TEM) and scanning (SEM) electron microscopic techniques. The design of our studies has utilized methodology that would; 1. best characterize the actual degradation process without artifacts introduced by fixation procedures and 2. allow for reproducible results.In our studies, the gastrocnemius muscle of the rat was chosen as the injection site. Prior to the injection of microcapsules the skin above the sites was shaved and tattooed for later recognition and recovery. 1.0 cc syringes were loaded with the desired quantity of microcapsules and the vehicle (0.5% hydroxypropylmethycellulose) drawn up. The syringes were agitated to suspend the microcapsules in the injection vehicle.

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