INFECTION WITH LEISHMANIA TROPICA MAJORS: GENETIC CONTROL IN INBRED MOUSE STRAINS

The response of inbred mouse strains to two polypeptides derived from multichain polyprolines, (T,G)-Pro--L and (Phe,G)-Pro--L, is different from the response of the same mouse strains to a similar series of polymers built on multi-poly-D,L-alanyl--poly-L-lysine, although the same short sequences of amino acids are attached to the side chains of the polypeptides in the two series. These results indicate that a portion of the side chain (e.g. polyalanine or polyproline) participates in the antigenic determinant. This was confirmed by studying the response of different mouse strains to two kinds of polypeptides: (T,G)-Pro-A--L 717 and 718 and (T,G)-A-Pro--L 719 and 721. Antibody assay of antisera to (Phe,G)-Pro--L with the cross-reacting antigens (T,G)-Pro--L and (Phe,G)-A-L indicates that different inbred mouse strains make antibodies specific for different parts of the same polypeptide. Thus, antibody from DBA/1 mice reacts almost exclusively with the (Phe,G) sequence, while SJL antisera bind only (T,G)-Pro--L and fail to bind (Phe,G)-A-L. The immune responses to the same amino acids on two different polypeptides (i.e. A--L and Pro--L) appear to be under separate genetic control.

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Differences in the response of inbred mouse strains to the factor increasing monocytopoiesis.

Journal of Experimental Medicine ◽

10.1084/jem.159.2.524 ◽

1984 ◽

Vol 159 (2) ◽

pp. 524-536 ◽

Cited By ~ 26

Author(s):

W Sluiter ◽

I Elzenga-Claasen ◽

A van der Voort van der Kley-van Andel ◽

R van Furth

Keyword(s):

Bone Marrow ◽

Listeria Monocytogenes ◽

Inflammatory Response ◽

Genetic Control ◽

Inflammatory Reaction ◽

Inbred Mouse ◽

Mouse Strains ◽

Inbred Mouse Strains ◽

Soluble Extract ◽

Cba Mice

Previous studies have shown that monocyte production during an inflammatory response is controlled by the factor increasing monocytopoiesis (FIM), secreted by macrophages at the site of inflammation. The inflammatory reaction to latex particles and a saline-soluble extract of Listeria monocytogenes (SEL), expressed as the number of monocytes in the circulation and of macrophages at the site of inflammation, was about twice as strong in C57BL/10 mice compared with CBA mice. This raised the question as to the mechanism underlying these differences. One possibility might be that these mouse strains differ with respect to the production of FIM, but this cannot be the case because the maximum levels of FIM activity in the serum of both C57BL/10 and CBA mice given latex or SEL intraperitoneally were almost the same; however, the courses of FIM activity in the two strains after intraperitoneal latex were not exactly synchronous. Another possibility is that the sensitivity of monocyte precursor cells for FIM differs. Evidence for the latter was provided by the finding that the intravenous injection of sera with FIM activity obtained from C57BL/10 and from CBA mice into the C57BL/10 mice evoked monocytosis, whereas CBA mice did not respond to these sera. Earlier studies showed that an increase of monocytes after the injection of serum containing FIM reflects increased monocyte production. Taken together, the results of the present study demonstrate that one of the mechanisms underlying the genetic control of the inflammatory response is, rather than enhanced FIM synthesis, the ability of monocyte precursors in the bone marrow to respond to FIM by increased monocyte production.

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Tracking genetic variation underlying differenzial reaction to TGF-beta signalling in inbred mouse strains

Zeitschrift für Gastroenterologie ◽

10.1055/s-0031-1285727 ◽

2011 ◽

Vol 49 (08) ◽

Author(s):

R Müllenbach ◽

I Ilkavets ◽

S Dooley ◽

F Lammert

Keyword(s):

Genetic Variation ◽

Inbred Mouse ◽

Mouse Strains ◽

Inbred Mouse Strains ◽

Tgf Beta

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POST-FERTILIZATION MATERNAL EFFECTS ON SPERM DIMENSIONS OF INBRED MOUSE STRAINS

Reproduction ◽

10.1530/jrf.0.0330175 ◽

1973 ◽

Vol 33 (1) ◽

pp. 175-177 ◽

Cited By ~ 2

Author(s):

K. P. PANT ◽

R. A. BEATTY

Keyword(s):

Maternal Effects ◽

Inbred Mouse ◽

Mouse Strains ◽

Inbred Mouse Strains

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THE Ah PHENOTYPE. SURVEY OF FORTY-EIGHT RAT STRAINS AND TWENTY INBRED MOUSE STRAINS

Genetics ◽

10.1093/genetics/100.1.79 ◽

1982 ◽

Vol 100 (1) ◽

pp. 79-87

Author(s):

Daniel W Nebert ◽

Nancy M Jensen ◽

Hisashi Shinozuka ◽

Heinz W Kunz ◽

Thomas J Gill

Keyword(s):

Specific Activity ◽

Inbred Mouse ◽

Inbred Mouse Strain ◽

Mouse Strains ◽

Ah Receptor ◽

Inbred Mouse Strains ◽

Sprague Dawley ◽

Rat Strains ◽

Specific Activities ◽

Inbred Rat

ABSTRACT Forty-four inbred and four randombred rat strains and 20 inbred mouse strains were examined for their Ah phenotype by determining the induction of liver microsomal aryl hydrocarbon (benzo[a]pyrene) hydroxylase activity (EC 1.14.14.1) by intraperitoneal treatment with either β-naphthoflavone or 3-methylcholanthrene. All 48 rat strains were found to be Ah-responsive. The maximally induced hydroxylase specific activities of the ALB/Pit, MNR/Pit, MR/Pit, SHR/Pit, and Sprague-Dawley strains were of the same order of magnitude as the basal hydroxylase specific activities of the ACI/Pit, F344/Pit, OKA/Pit, and MNR/N strains. Six of the 20 mouse strains were Ah-nonresponsive (i.e. lacking the normal induction response and presumably lacking detectable amounts of the Ah receptor). The basal hydroxylase specific activities of the BDL/N, NFS/N, STAR/N, and ST/JN mouse strains were more than twice as high as the maximally induced hydroxylase specific activity of the CBA/HT strain.——To date, 24 Ah-nonresponsive mouse strains have been identified, out of a total of 68 known to have been characterized. The reasons for not finding a single Ah-nonresponsive inbred rat strain—as compared with about one Ah-nonresponsive inbred mouse strain found for every three examined—remain unknown.

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