Biological Underpinnings of Sex Differences in Eating Disorders

Author(s):  
Kristen M. Culbert ◽  
Sarah E. Racine ◽  
Kelly L. Klump
2018 ◽  
Vol 6 (1) ◽  
Author(s):  
Jennifer S. Coelho ◽  
Tiffany Lee ◽  
Priscilla Karnabi ◽  
Alex Burns ◽  
Sheila Marshall ◽  
...  

2020 ◽  
Author(s):  
Zeynep Yilmaz ◽  
Katherine Schaumberg ◽  
Matt Halvorsen ◽  
Erica L. Goodman ◽  
Leigh C. Brosof ◽  
...  

Clinical, epidemiological, and genetic findings support an overlap between eating disorders, obsessive-compulsive disorder (OCD), and anxiety symptoms. However, little research has examined the role of genetic factors in the expression of eating disorders and OCD/anxiety phenotypes. We examined whether the anorexia nervosa (AN), OCD, or AN/OCD transdiagnostic polygenic scores (PGS) predict eating disorders, OCD, and anxiety symptoms in a large population-based developmental cohort. Using summary statistics files from the Psychiatric Genomics Consortium Freeze 2 AN and Freeze 1 OCD GWAS, we first conducted an AN/OCD transdiagnostic GWAS meta-analysis and then calculated PGS for AN, OCD, and AN/OCD in participants from the Avon Longitudinal Study of Parents and Children with available genetic and phenotype data on eating disorder, OCD, and anxiety diagnoses and symptoms (sample size 3,212-5,369 per phenotype). We observed sex differences in the PGS prediction of eating disorder, OCD, and anxiety-related phenotypes, with AN genetic risk manifesting at an earlier age and playing a more prominent role in eating disorder phenotypes in boys than in girls. Compulsive exercise was the only phenotype predicted by all three PGS (e.g., PAN(boys)=0.0141 at age 14; POCD(girls)=0.0070 at age 16; PAN/OCD(all)=0.0297 at age 14). Our results suggest that earlier detection of eating disorder, OCD, and anxiety-related symptoms could be made possible by including measurement of genetic risk for these psychiatric conditions while being mindful of sex differences.


2019 ◽  
Vol 33 ◽  
pp. 73-77 ◽  
Author(s):  
Mary Quattlebaum ◽  
Natasha L. Burke ◽  
M.K. Higgins Neyland ◽  
William Leu ◽  
Natasha A. Schvey ◽  
...  

2015 ◽  
Vol 16 ◽  
pp. 78-83 ◽  
Author(s):  
Anna Christin Makowski ◽  
Eva E. Mnich ◽  
Matthias C. Angermeyer ◽  
Bernd Löwe ◽  
Olaf von dem Knesebeck

2006 ◽  
Vol 137 (6) ◽  
pp. 773-781 ◽  
Author(s):  
Rita DiGioacchino DeBate ◽  
Elizabeth Vogel ◽  
Lisa A. Tedesco ◽  
James Alan Neff

Author(s):  
Jason M. Nagata ◽  
Paola Bojorquez‐Ramirez ◽  
Anthony Nguyen ◽  
Kyle T. Ganson ◽  
Vanessa I. Machen ◽  
...  

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