Multiscale Agent-Based Computer Models in Skeletal Tissue Regeneration

Decellularized bone extracellular matrix in skeletal tissue engineering

Biochemical Society Transactions ◽

10.1042/bst20190079 ◽

2020 ◽

Vol 48 (3) ◽

pp. 755-764

Author(s):

Benjamin B. Rothrauff ◽

Rocky S. Tuan

Keyword(s):

Tissue Engineering ◽

Bone Regeneration ◽

Tissue Regeneration ◽

Animal Studies ◽

Tumor Resection ◽

Regenerative Capacity ◽

Skeletal Tissue ◽

Large Bone

Bone possesses an intrinsic regenerative capacity, which can be compromised by aging, disease, trauma, and iatrogenesis (e.g. tumor resection, pharmacological). At present, autografts and allografts are the principal biological treatments available to replace large bone segments, but both entail several limitations that reduce wider use and consistent success. The use of decellularized extracellular matrices (ECM), often derived from xenogeneic sources, has been shown to favorably influence the immune response to injury and promote site-appropriate tissue regeneration. Decellularized bone ECM (dbECM), utilized in several forms — whole organ, particles, hydrogels — has shown promise in both in vitro and in vivo animal studies to promote osteogenic differentiation of stem/progenitor cells and enhance bone regeneration. However, dbECM has yet to be investigated in clinical studies, which are needed to determine the relative efficacy of this emerging biomaterial as compared with established treatments. This mini-review highlights the recent exploration of dbECM as a biomaterial for skeletal tissue engineering and considers modifications on its future use to more consistently promote bone regeneration.

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Biological and Tribological Assessment of Poly(Ethylene Oxide Terephthalate)/Poly(Butylene Terephthalate), Polycaprolactone, and Poly (L\DL) Lactic Acid Plotted Scaffolds for Skeletal Tissue Regeneration

Advanced Healthcare Materials ◽

10.1002/adhm.201500067 ◽

2015 ◽

Vol 5 (2) ◽

pp. 232-243 ◽

Cited By ~ 4

Author(s):

Wilhelmus J. Hendrikson ◽

Xiangqiong Zeng ◽

Jeroen Rouwkema ◽

Clemens A. van Blitterswijk ◽

Emile van der Heide ◽

...

Keyword(s):

Lactic Acid ◽

Ethylene Oxide ◽

Tissue Regeneration ◽

Butylene Terephthalate ◽

Skeletal Tissue ◽

Poly Ethylene Oxide ◽

Poly Ethylene

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Erratum to “Influence of cyclic bending loading on in vivo skeletal tissue regeneration from periosteal origin” [Orthop Traumatol Surg Res 96 (2010) 833–839]

Orthopaedics & Traumatology Surgery & Research ◽

10.1016/j.otsr.2010.12.002 ◽

2011 ◽

Vol 97 (2) ◽

pp. 227

Author(s):

D. Moukoko ◽

D. Pourquier ◽

M. Pithioux ◽

P. Chabrand

Keyword(s):

Tissue Regeneration ◽

Cyclic Bending ◽

Skeletal Tissue ◽

Bending Loading

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Nanoporous structured carbon nanofiber–bioactive glass composites for skeletal tissue regeneration

Journal of Materials Chemistry B ◽

10.1039/c5tb00921a ◽

2015 ◽

Vol 3 (26) ◽

pp. 5300-5309 ◽

Cited By ~ 16

Author(s):

Cuihua Zhang ◽

Dan Cheng ◽

Tianhong Tang ◽

Xiaolong Jia ◽

Qing Cai ◽

...

Keyword(s):

Bioactive Glass ◽

Carbon Nanofibers ◽

Tissue Regeneration ◽

Carbon Nanofiber ◽

Glass Composites ◽

Skeletal Tissue ◽

Composite Carbon

Bioactive glass (BG) decorated nanoporous composite carbon nanofibers (PCNF–BG) were prepared for the purpose of obtaining effective substrates for skeletal tissue regeneration.

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