Serum Nitric Oxide Metabolites and the Incidence of Metabolic Syndrome and Its Phenotypes: A Population-Based Prospective Study

2019 ◽  
pp. 309-310
Author(s):  
Zahra Bahadoran ◽  
Parvin Mirmiran ◽  
Fereidoun Azizi ◽  
Asghar Ghasemi
Keyword(s):  
Nitric Oxide ◽  
Metabolic Syndrome ◽  
Prospective Study ◽  
Population Based ◽  
Nitric Oxide Metabolites

Serum nitric oxide metabolites and hard clinical endpoints: a population-based prospective study

2019 ◽  
Vol 53 (4) ◽  
pp. 176-182 ◽  
Author(s):  
Zahra Bahadoran ◽  
Parvin Mirmiran ◽  
Zhaleh Tahmasebinejad ◽  
Fereidoun Azizi ◽  
Asghar Ghasemi
Keyword(s):  
Nitric Oxide ◽  
Prospective Study ◽  
Population Based ◽  
Clinical Endpoints ◽  
Nitric Oxide Metabolites

scholarly journals Lipid Peroxidation, Nitric Oxide Metabolites, and Their Ratio in a Group of Subjects with Metabolic Syndrome

2014 ◽  
Vol 2014 ◽  
pp. 1-8 ◽  
Author(s):  
Gregorio Caimi ◽  
Rosalia Lo Presti ◽  
Maria Montana ◽  
Davide Noto ◽  
Baldassare Canino ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Metabolic Syndrome ◽  
Lipid Peroxidation ◽  
Hdl Cholesterol ◽  
Thiobarbituric Acid ◽  
Entire Group ◽  
Inflammatory Status ◽  
Nitric Oxide Metabolites ◽  
Nitrite Nitrate ◽  
Normal Controls

Our aim was to evaluate lipid peroxidation, expressed as thiobarbituric acid-reactive substances (TBARS), nitric oxide metabolites (nitrite + nitrate) expressed asNOx, and TBARS/NOxratio in a group of subjects with metabolic syndrome (MS). In this regard we enrolled 106 subjects with MS defined according to the IDF criteria, subsequently subdivided into diabetic (DMS) and nondiabetic (NDMS) and also into subjects with a low triglycerides/HDL-cholesterol (TG/HDL-C) index or with a high TG/HDL-C index. In the entire group and in the four subgroups of MS subjects we found an increase in TBARS andNOxlevels and a decrease in TBARS/NOxratio in comparison with normal controls. Regarding all these parameters no statistical difference between DMS and NDMS was evident, but a significant increase inNOxwas present in subjects with a high TG/HDL-C index in comparison with those with a low index. In MS subjects we also found a negative correlation between TBARS/NOxratio and TG/HDL-C index. Considering the hyperactivity of the inducible NO synthase in MS, these data confirm the altered redox and inflammatory status that characterizes the MS and suggest a link between lipid peroxidation, inflammation, and insulin resistance, evaluated as TG/HDL-C index.

scholarly journals Prospective Study of Sex-Specific Adiponectin Changes and Incident Metabolic Syndrome: The ARIRANG Study

2019 ◽  
Vol 8 (5) ◽  
pp. 599
Author(s):  
Ji Hye Huh ◽  
Tae Woong Yoon ◽  
Dae Ryong Kang ◽  
Jang Young Kim
Keyword(s):  
Metabolic Syndrome ◽  
Prospective Study ◽  
Adiponectin Level ◽  
Density Lipoprotein ◽  
Hdl Cholesterol ◽  
Population Based ◽  
Clinical Role ◽  
High Baseline ◽  
The Individual

We investigated whether changes in adiponectin levels over time predict incident metabolic syndrome (MetS) in a population-based prospective study. In total, 1110 subjects were categorized into four groups according to their sex-specific median baseline adiponectin levels and the change in adiponectin levels at follow-up: low baseline adiponectin and decreased adiponectin during follow-up (LB&DF), low baseline adiponectin and increased adiponectin during follow-up (LB&IF), high baseline adiponectin and decreased adiponectin during follow-up (HB&DF), and high baseline adiponectin and increased adiponectin during follow-up (HB&IF). During the median 2.4-year follow-up period, 180 (16.2%) subjects developed MetS. Compared to the LB&DF group, the fully adjusted hazard ratio (95% confidence interval) for incident MS was the lowest in the HB&IF group (0.33, (0.17–0.63)), followed by the HB&DF group (0.58, (0.40–0.84)) and LB&IF group (0.63, (0.41–0.93)). This phenomenon was more prominent in men than in women. Among the individual MetS components, increased adiponectin levels during follow-up were significantly associated with lower risks of incident low high density lipoprotein (HDL) cholesterol and incident high blood pressure. This finding suggests that a change in adiponectin level, as well as the baseline adiponectin level, might have a clinical role in the development of MetS among men.

Serum nitric oxide metabolites in subjects with metabolic syndrome

2008 ◽  
Vol 41 (16-17) ◽  
pp. 1342-1347 ◽  
Author(s):  
Saleh Zahedi Asl ◽  
Asghar Ghasemi ◽  
Fereidoun Azizi
Keyword(s):  
Nitric Oxide ◽  
Metabolic Syndrome ◽  
Nitric Oxide Metabolites

scholarly journals Proinflammatory Dietary Intake is Associated with Increased Risk of Metabolic Syndrome and Its Components: Results from the Population-Based Prospective Study

Nutrients ◽  
2020 ◽  
Vol 12 (4) ◽  
pp. 1196
Author(s):  
Imran Khan ◽  
Minji Kwon ◽  
Nitin Shivappa ◽  
James R. Hébert ◽  
Mi Kyung Kim
Keyword(s):  
Metabolic Syndrome ◽  
Prospective Study ◽  
Menopausal Status ◽  
Positive Association ◽  
Hdl Cholesterol ◽  
Population Data ◽  
Population Based ◽  
Inflammatory Index ◽  
Increased Risk ◽  
Low Hdl

Metabolic syndrome (MetS) is a major public health challenge throughout the world, although studies on its association with the inflammatory potential of diet are inconsistent. The aim of this prospective study was to assess the association between the Dietary Inflammatory Index (DII®) and the risk of MetS and its components in a Korean population. Data from 157,812 Korean adults (mean age 52.8 years; 53,304 men and 104,508 women with mean follow-up of 7.4 years) collected by members of the Korean Genome and Epidemiology Study form the basis for this report. DII scores were calculated based on Semi-Quantitative Food-Frequency Questionnaire data. Multivariable-adjusted Cox proportional hazard models were used to estimate the association between DII scores and MetS. In women, higher DII scores (pro-inflammatory diet) increased the risk of MetS (hazard ratio [HR]quintile5 v. 1 1.43; 95% confidence interval (CI) 1.21–1.69; p for trend ≤ 0.0001) and its five components. A positive association was observed for postmenopausal women, with a 50% higher risk of developing MetS (HRquintile5 v. 1 1.50; 95% CI 1.23–1.83; p for trend = 0.0008) after fully adjusting for potential confounders. Irrespective of the menopausal status of women, higher DII (=Q5) scores were positively associated with all 5 components of MetS (p < 0.05). In men, higher DII scores significantly increased the risk of low HDL cholesterol [HR]quintile5 v. 1 1.59 (1.27–1.99); p for trend = 0.0001], elevated waist circumferences [HR]quintile5 v. 1 1.28 (1.08–1.52); p for trend = 0.01], and high blood pressure [HR]quintile5 v. 1 1.17 (1.03–1.32); p for trend = 0.05]. These results indicate that diet with pro-inflammatory potential, as represented by higher DII scores, is prospectively associated with increased risk of MetS, and the relationship is stronger in women than in men.

Circulating nitric oxide metabolites and the risk of cardiometabolic outcomes: a prospective population-based study

Biomarkers ◽  
2019 ◽  
Vol 24 (4) ◽  
pp. 325-333
Author(s):  
Parvin Mirmiran ◽  
Zahra Bahadoran ◽  
Zhaleh Tahmasebinejad ◽  
Fereidoun Azizi ◽  
Asghar Ghasemi
Keyword(s):  
Nitric Oxide ◽  
Population Based ◽  
Population Based Study ◽  
Nitric Oxide Metabolites

scholarly journals The Association of Dietary l-Arginine Intake and Serum Nitric Oxide Metabolites in Adults: A Population-Based Study

Nutrients ◽  
2016 ◽  
Vol 8 (5) ◽  
pp. 311 ◽  
Author(s):  
Parvin Mirmiran ◽  
Zahra Bahadoran ◽  
Asghar Ghasemi ◽  
Fereidoun Azizi
Keyword(s):  
Nitric Oxide ◽  
Population Based ◽  
Population Based Study ◽  
Nitric Oxide Metabolites

Abstract 169: Stable Nitric Oxide Metabolites Levels and Their Relation to the Metabolic Syndrome Components in Essential Hypertension

Hypertension ◽  
2013 ◽  
Vol 62 (suppl_1) ◽  
Author(s):  
Natalia Murashko ◽  
Valery Podzolkov ◽  
Anna Bragina
Keyword(s):  
Nitric Oxide ◽  
Metabolic Syndrome ◽  
Essential Hypertension ◽  
Visceral Obesity ◽  
High Plasma ◽  
Glucose Levels ◽  
The Metabolic Syndrome ◽  
Blood Glucose Levels ◽  
Nitric Oxide Metabolites ◽  
Plasma Leptin

Objective: To investigate levels of the stable nitric oxide metabolites (NOx) in relation to components of the metabolic syndrome (MS) in essential hypertension (EH) Methods: We examined 124 untreated patients with EH (mean age 51.4 ± 6.5 years, mean hypertension duration 8,5±7,6 years) and 25 healthy volunteers with comparable age (47.2 ± 7.8 years, p>0,05). Plasma leptin levels were measured by radioimmunoassay, plasma NOx - by spectrophotometry. Results were processed with Statistica 6.0 software. Results: Visceral obesity had 64% of hypertensive patients, dyslipidemia - 80.6%, hyperglycemia - 41,6%, MS - 24%. In 32% the MS diagnosis was based on the presence of two additional criteria, in 68% - on three. NOx levels were significantly higher in hypertensives (43,18±21, μmol/l) than in controls (28.3 ± 9.6 μmol/l) ( p = 0.01). In patients with hyperglycemia NOx concentration was higher (46,5 ± 23,9 μmol/l) than in those without it (38,6±18, μmol/l)(p<0,05). NOx levels correlated with blood glucose levels (r=0,32, p<0,05). NOx concentration did not differ between hypertensives with or without dyslipidemia (43,2±22,2 and 42,05±21,1 μmol/l, accordingly p>0,05). Nonobese hypertensives had lower NOx concentration than obese hypertensives (38,8±17,9 and 48,5±24,7 μmol/l, p<0,05). NOx levels correlated with the presence (r=-0,44, p<0,05) and degree of obesity (r=-0,3, p<0,05). NOx levels were lower in patients with MS (31,6±11,3 and 47,05±20,7 μmol/l, p<0,05). NOx levels decreased with the increase of additional MS criterias: 37,99 ± 12,6 μmol/l in the presence of 2 and 28,3 ± 9,6 μmol/l in the presence of 3 criteria (p<0,05). NOx levels correlated with the amount MS components (r=-0,38, p<0,05). Hypertensives with high leptin levels had lower NOx concentration (29 ± 12,2 μmol/l), compared to hypertensives with normal leptin levels (34,7±10,5 μmol/l) (p<0,05). Conclusion: In essential hypertension NOx metabolism differs in relation to metabolic status. Hypertension per se and hyperglycemia increase NOx levels, whereas MS and its essential signsas visceral obesity and high plasma leptin level decrease NOx levels.

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