Histopathology of the Pilosebaceous Unit and Interstitium of Hidradenitis Suppurativa

2022 ◽  
pp. 37-44
Author(s):  
Farah Succaria ◽  
Michelle L. Kerns ◽  
Angel S. Byrd
Keyword(s):  
Hidradenitis Suppurativa ◽  
Pilosebaceous Unit

scholarly journals Disseminate Recurrent Folliculitis and Hidradenitis Suppurativa Are Associated Conditions: Results From a Retrospective Study of 131 Patients With Down Syndrome and a Cohort of 12,351 Pediatric Controls

2019 ◽  
pp. 187-194 ◽  
Author(s):  
Andrea Sechi ◽  
Alba Guglielmo ◽  
Annalisa Patrizi ◽  
Francesco Savoia ◽  
Guido Cocchi ◽  
...  
Keyword(s):  
Down Syndrome ◽  
Trisomy 21 ◽  
Hidradenitis Suppurativa ◽  
Control Group ◽  
Pilosebaceous Unit ◽  
Cutaneous Manifestations ◽  
Regional Center ◽  
Wide Range ◽  
Associated Conditions ◽  
The Mean

Background: Hidradenitis suppurativa (HS) is a chronic, inflammatory, recurrent skin disease of the pilosebaceous unit characterized by protean manifestations. Several studies have found an increased incidence and earlier presentation of this disease in patients carrying trisomy 21. Patients with Down syndrome (DS) have a higher risk of developing a wide range of cutaneous manifestations, including HS and chronic folliculitis. Recently, disseminate recurrent folliculitis (DRF) has been reported as an atypical monosymptomatic feature of HS at its onset. Objective: To assess the prevalence of HS and DRF by comparing a cohort of patients carrying trisomy 21 vs pediatric controls. Methods: A retrospective 2-year monocentric clinical study was performed by collecting clinical data of 131 patients with DS, aged 4-36 years, followed at the Dermatology Unit and Down Syndrome Regional Center of Bologna University. Data were matched with those coming from 12,351 pediatric controls. Results: In DS patients, DRF and HS showed a prevalence of, respectively, 6.8% and 24.4%, while 5.3% of patients presented both diseases. In the control group the prevalence for HS+ and DRF+ was 0.5% and 1.2%, respectively, with a 0.14% of overlap cases. The association between HS and DRF proved to be statistically significant in both groups (P < 0.05). In the DS cohort the mean age of symptoms onset was 15.67 (SD: 2.29) years for HS and 13.11 (SD: 4.93) years for DRF. Buttocks were the most frequently affected body area for DRF followed by the inguinocrural area, while in HS buttocks were less frequently involved than groins and upper thighs. Conclusions: Because of the later onset of HS, patients with DRF at an early age should be monitored for the possible onset of HS in the apocrine-bearing areas.

scholarly journals Leflunomide-Induced Hidradenitis Suppurativa

2020 ◽  
Vol 2020 ◽  
pp. 1-2
Author(s):  
Achraf Machan ◽  
Hasna Azendour ◽  
Hamza Toufik ◽  
Lahsen Achemlal ◽  
Mohammed Boui ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Rheumatoid Arthritis ◽  
Inflammatory Disease ◽  
Hidradenitis Suppurativa ◽  
Pilosebaceous Unit ◽  
Drug Induced

Hidradenitis suppurativa is an inflammatory disease of the pilosebaceous unit with a chronic intermittent course and a devastating effect on quality of life. Rare reports of drug-induced hidradenitis suppurativa exist. We report on 2 women on follow-up for rheumatoid arthritis, who presented hidradenitis suppurativa after different periods of treatment with leflunomide and who improved few weeks after discontinuation of the medication.

scholarly journals The Clinical Relevance of the Microbiome in Hidradenitis Suppurativa: A Systematic Review

Vaccines ◽  
2021 ◽  
Vol 9 (10) ◽  
pp. 1076
Author(s):  
Dillon Mintoff ◽  
Isabella Borg ◽  
Nikolai Paul Pace
Keyword(s):  
Systematic Review ◽  
Chronic Disease ◽  
Environmental Factors ◽  
Clinical Relevance ◽  
Hidradenitis Suppurativa ◽  
Human Microbiome ◽  
Pilosebaceous Unit ◽  
Genetic And Environmental Factors

Hidradenitis suppurativa is a chronic disease of the pilosebaceous unit. The name of the condition is a testament to the presumed relationship between the disease and the microbiome. The pathophysiology of hidradenitis suppurativa is, however, complex and believed to be the product of a multifactorial interplay between the interfollicular epithelium, pilosebaceous unit, microbiome, as well as genetic and environmental factors. In this review we assimilate the existing literature regarding the role played by the human microbiome in HS in various contexts of the disease, including the pathophysiologic, therapeutic, and potentially, diagnostic as well prognostic. In conclusion, the role played by the microbiome in HS is extensive and relevant and can have bench-to-bedside applications.

Host-defense mechanisms in hidradenitis suppurativa

1977 ◽  
Vol 113 (4) ◽  
pp. 450-453 ◽  
Author(s):  
V. C. Dvorak
Keyword(s):  
Host Defense ◽  
Defense Mechanisms ◽  
Hidradenitis Suppurativa

The role of depilation and deodorants in hidradenitis suppurativa

1982 ◽  
Vol 118 (2) ◽  
pp. 101-102 ◽  
Author(s):  
W. P. Morgan
Keyword(s):  
Hidradenitis Suppurativa

Temporary x-ray epilation therapy of chronic axillary hidradenitis suppurativa

1965 ◽  
Vol 92 (6) ◽  
pp. 690-694 ◽  
Author(s):  
I. Zeligman
Keyword(s):  
Hidradenitis Suppurativa ◽  
X Ray ◽  
Axillary Hidradenitis Suppurativa

Surgical treatment of extensive perianal hidradenitis

2020 ◽  
Vol 99 (9) ◽  
Keyword(s):  
Surgical Treatment ◽  
Hidradenitis Suppurativa ◽  
Soft Tissues ◽  
Case Reports ◽  
Radical Excision ◽  
Skin Flaps ◽  
Perianal Area ◽  
Apocrine Glands ◽  
Patient Preparation ◽  
Two Stages

Introduction: Perianal hidradenitis suppurativa is a chronic recurrent inflammatory, suppurative, and fistulising disease of apocrine glands, adjacent anal canal and soft tissues. Perianal area is the second most common affected area after axilla. There are three grades of the disease. Hidradenitis suppurativa represents a chronic, recurrent, deep-seated folliculitis resulting in abscesses, followed by the formation of sinus tracts and subsequent scarring. Perianal hidradenitis suppurativa is the last and the most serious grade of the disease and a specific access is needed for patient preparation and surgical treatment alone. The currently preferred method of treatment for patients with extensive perianal hidradentitis is excision and closure with combination of skin flaps, primary suture and skin graft in one or two stages. Case reports: There are three case reports of perianal hidradenitis suppurativa in this article. The local and overall initial treatment of patients followed by a radical excision and closure with a rotation skin flaps and skin grafts is described. The final results were satisfactory, with no recurrence or serious complication.

Characterization of comorbid conditions burdening hidradenitis suppurativa: a multicentric observational study

2020 ◽  
Vol 155 (3) ◽  
Author(s):  
Andrea Chiricozzi ◽  
Giulia Giovanardi ◽  
Dante R. Caposiena Caro ◽  
Michela Iannone ◽  
Clara De Simone ◽  
...  
Keyword(s):  
Observational Study ◽  
Hidradenitis Suppurativa ◽  
Comorbid Conditions

New insights into mechanism of Notch signaling in hidradenitis suppurativa

2020 ◽  
Vol 155 (4) ◽  
Author(s):  
Emanuele Scala ◽  
Anna Balato ◽  
Claudio Marasca ◽  
Roberta Di Caprio ◽  
Annunziata Raimondo ◽  
...  
Keyword(s):  
Notch Signaling ◽  
Hidradenitis Suppurativa

Continuous Weekly Adalimumab is the Optimal Long-Term Strategy for Patients with Moderate-to-Severe Hidradenitis Suppurativa: Results from the PIONEER Open Label Extension Trial

2017 ◽  
Vol 1 ◽  
pp. s129
Author(s):  
Alexa B Kimball ◽  
Martin M Okun ◽  
Gerit Mulder
Keyword(s):  
Hidradenitis Suppurativa ◽  
Open Label ◽  
Open Label Extension ◽  
Extension Trial

Abstract Not Available Disclosures: Study supported by AbbVie.

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