In the article, the authors analyzed the literary sources of Russian and foreign authors engaged in research of project management methods in solving problems of ensuring economic security. The aim of the study is to consider the possibility of applying the project approach in managing economic security at the meso-level based on the analysis of scientific publications by Russian and foreign scientists on this topic. Research methods: information search, systematization, logical, system and content analysis. The authors identify 5 approaches to project management while ensuring economic security in modern Russian and foreign scientific research. In conclusion, it is concluded that it is necessary to introduce project risk management at the level of regional administrations with a positive cost-benefit ratio, that is, ensuring an acceptable level of economic security.