Feasibility Study Fishing Tour Project in Dongkal Village, East Pondok Jagung, North Serpong, South Tangerang City, Banten

The purpose of writing a feasibility study paper on fishing tourism business is to assist the village government in realizing increased economic growth for the community around village. The author also wants to carry out several feasibility measurements in a project development by analyzing, viewing and measuring several measurement indicators using the Net Present Value method, Internal Return Rate, Cost Benefit Ratio, Return on Investment, and Return on Investment Period. Based on the results of the analysis of the financial feasibility test with this method, the authors use a loan interest rate of 11% per year to operate. From the calculation results obtained a positive number of Net Present Value of Rp. 493,276 million, the value of the Internal Rate of Return 12.1388% > 11% (Interest Rate), the value of the Cost Benefit Ratio 1.5165 > 1, with a payback period of 3.0825 years < 5 years (Bank loan repayment period).

An application of physics: simply supported bridges made of post-tensioned concrete and structural steel beams

Bridges represent an important application of physics capable of solving real transportation problems. Knowledge of convenience of different mechanical solutions when analyzing and designing bridge is needed. For these reasons, this work is focused on the study of convenience of using two types of bridges. Simply supported short-medium span bridges (30 m to 45 m) are usually excessively long when choosing reinforced concrete solutions and usually short for other types of structures such as cable-stayed or cantilever bridges. The suitability of simply supported bridges leads to the need of studying their cost benefit ratios. This work studies the cost benefit ratio for post-tensioned concrete beams and structural steel girders in simply supported straight bridges. Eight models built of type I sections were used in both cases to analyze the bridges using a software based on the stiffness method. Span of each bridge was set to 30 m, 35 m, 40 m, and 45 m. The convenience of each type of bridge was done comparing the total and the cost per linear meter of each solution (post-tensioned and structural steel). Comparison was done using material consumption, labor, and construction processes costs only. Also, allowable vertical displacement given by current bridge design standards was verified.

Evaluation of Suitable IPM Module for Management of YMV Disease in Mungbean under West Central Table Land Zone of Odisha

Background: YMV disease in mungbean is one of the major disease causing heavy losses annually throughout the country. As the disease is transmitted by insect vector, management of vector is important to check the YMV disease that can minimise the losses. The present investigation was aimed to evaluate different IPM modules for management of YMV disease of mungbean. Methods: Field experiments were carried out during Rabi season of 2016-17 and 2017-18 at the Research Farm of Regional Research and Technology Transfer Station, Chiplima, Sambalpur, Odisha, India. Population of whitefly was recorded on three leaves selected from top, middle and bottom canopy of the plant. Disease severity was recorded by using 0-9 scale. Result: The IPM module i.e. seed treatment with Thiamethoxam 25 WG @ 5 gm kg-1 of seed, installation of yellow sticky trap @ 50 ha-1 and spraying of Acetamiprid 20 SP @ 0.3 gm l-1 of water was found as the most effective among all other modules. Pooled analysis of two years data revealed that 65.5% YMV disease control and 59.3% reduction of white fly population over control were performed by the said IPM module. A maximum increase in yield (84.8%) and highest cost benefit ratio (1.77) were also achieved with the module.

Leveraging Visual Outcome Measures to Advance Therapy Development in Neuroimmunologic Disorders

The visual system offers unparalleled precision in the assessment of neuroaxonal damage. With the majority of patients with multiple sclerosis (MS) experiencing afferent and efferent visual dysfunction, outcome measures capturing these deficits provide insight into neuroaxonal injury, even in those with minimal disability. Ideal for use in clinical trials, visual measures are generally inexpensive, accessible, and reproducible. Quantification of visual acuity, visual fields, visual quality of life, and electrophysiologic parameters allows assessment of function, whereas optical coherence tomography (OCT) provides reliable measures of the structural integrity of the anterior afferent visual pathway. The technology of oculomotor biometrics continues to advance, and discrete measures of fixation, smooth pursuit, and saccadic eye movement abnormalities are ready for inclusion in future trials of MS progression. Visual outcomes allow tracking of neuroaxonal injury and aid in distinguishing MS from diseases such as neuromyelitis optica spectrum disorder (NMOSD) or myelin oligodendrocyte glycoprotein antibody–associated diseases (MOGAD). OCT has also provided unique insights into pathophysiology, including the identification of foveal pitting in NMOSD, possibly from damage to Müller cells, which carry an abundance of aquaporin-4 channels. For some study designs, the cost-benefit ratio favors visual outcomes over more expensive MRI outcomes. With the next frontier of therapeutics focused on remyelination and neuroprotection, visual outcomes are likely to take center stage. As an international community of collaborative, committed, vision scientists, this review by the International MS Visual System Consortium (IMSVISUAL) outlines the quality standards, informatics, and framework needed to routinely incorporate vision outcomes into MS and NMOSD trials.

Clinical and Economic Impact of Pharmacists’ Intervention on Care of Pediatric Hematology and Oncology Patients

Introduction Children with cancer may be one of the most vulnerable groups to drug-related adverse events because they possess characteristics of patients with cancer as well as pediatric patients. To evaluate the clinical and economic impact of pharmacists’ intervention on the care of pediatric hematology and oncology patients in the inpatient and outpatient settings of a children's hospital. Methods The pharmacist-intervention records from 2017 were retrospectively reviewed. Intervention rate, type of drug-related problems, acceptance rate, and frequently involved drugs in pharmacist interventions were analyzed. One physician and one pharmacist evaluated the clinical significance of each intervention. A cost-benefit analysis was conducted from hospital and patient perspective. The benefit from cost savings by reducing the number of prescribed drugs that are disposed was estimated as the benefit from hospital perspective. The benefit from cost avoidance based on the potential to avoid an adverse drug event (ADE) was estimated as the benefit from patient perspective. The cost of reviewing prescriptions was estimated based on the pharmacists’ salary and the time involved. Results In 2017, 2361 interventions were performed in 381 pediatric patients with cancer. The acceptance rate was 97.2%. More than half of the interventions were regarded as clinically “significant” (58.8%) and “very significant” (14.6%). The cost-benefit of US$28,705 was determined from hospital perspective, with a cost-benefit ratio of 1.45:1. The cost-benefit of US$35,611 was calculated from patient perspective, with a cost-benefit ratio of 1.55:1. Conclusions Pharmacists’ intervention in the care of hematology and oncology pediatric patients was effective in preventing clinically significant ADEs and had a positive economic impact on the health-care budget from both hospital and patient perspective.

Gut and Colony Microbiota of Honey Bees: Social Immunity and Opportunism Overwinter

Overwintering is a major contributor to honey bee colony loss and involves factors that influence disease susceptibility. Honey bees possess a secretory head gland that interfaces with the extended social environment on many levels. With the coming of winter, colonies produce a long-lived (diutinus) worker phenotype that survives until environmental conditions improve. We used a known-age worker cohort to investigate microbiome integrity and social gene expression of diutinus workers overwinter. We provide additional context by contrasting host-microbial interactions from warm outdoor and cold indoor overwintering environments. Our results provide the first evidence that social immune gene expression is associated with diutinus bees, and highlight the midgut as a target of opportunistic disease overwinter. Host microbial interactions suggest opportunistic disease progression and resistance in diutinus workers, but susceptibility to opportunistic disease in younger workers that emerged during the winter, including increases in Enterobacteriaceae, fungal load and bacterial diversity abundance. The results are consistent with increased social immunity overwinter, including host associations with the colony microbiota, and a social immune response by long-lived diutinus workers to combat microbial opportunism. The cost/benefit ratio associated with limited expression of the diutinus phenotype may be a strong determinant of colony survival overwinter.

A Design Method for the Roadside Clear Zone Based on Accident Simulation Analysis

In order to improve the safety design of roadside areas and reduce the loss of roadside accidents, this paper uses PC-Crash software to perform an accident simulation analysis. By recording the track of the vehicle after entering the roadside, the recommended widths of the roadside clear zone for different operating speeds and horizontal curve radii in straight and curved sections are given. According to our previous research data, the conditions for setting the roadside clear zone are proposed. Finally, based on a cost-benefit ratio analysis, a comprehensive risk index method is adopted to evaluate the social stability risk of the project and conduct research on the design method of the roadside clear zone. The results show that the width of the roadside clear zone has an exponential relation with the departure speed and a power relation with the horizontal curve radius. The research results realize the accurate calculation of the roadside clear zone width and fill in the gaps of the relevant specifications and guidelines in the setting conditions of the roadside clear zone.

Evaluation of IPM module against major insect pests of green gram, Vigna radiata (L.) Wilczek in lower Gangetic plains of West Bengal

An experiment was carried out to evaluate the efficacy of integrated management practices over farmers’ practices against insect pest complex of green gram (Vigna radiata L. Wilczek) during kharif season in the ‘A-B’ Block Farm of Bidhan Chandra Krishi Viswavidyalaya in 2019. The results revealed that the incidence of all of the insect pests viz. whitefly, pulse aphid, jassid, flower thrips, gram pod borer, spotted pod borer, blue butterfly, plant bug and pod bug was recorded comparatively less in Integrated Pest Management (IPM) plot as compared to farmers’ practices. The seed yield of green gram was also recorded a higher (1382.22 kg ha-1) in plots treated with integrated approaches as compared to farmer’s practices (476.94 kg ha-1). IPM module recorded maximum cost benefit ratio along with higher gross return and net profit as against farmers’ practices.

Multi-User Virtual Reality for Remote Collaboration in Construction Projects: A Case Study with High-Rise Elevator Machine Room Planning

Virtual Reality (VR) is considered among the major technologies to address the inefficient collaboration issue caused by the predominant use of 2D drawings in the construction industry. However, there is still a knowledge gap between researchers and practitioners about the actual benefits of VR in the business context. This paper presents the benefits of VR usage in four real-life high-rise elevator projects from the user and business perspectives. Four VR environments of actual machine rooms for planning were created and tested in a multi-user setting. Overall, users find VR more intuitive than conventional tools to enhance planning accuracy and collaboration. The results also show that VR brings significant economic savings and gains for business in the industry. Future study should investigate the real cost-benefit ratio of VR and streamline its technical implementation within construction projects. The research contributes to the current body of knowledge by providing real-life economic benefits and directions to address the research gap in both academia and industry to promote the wide adoption of VR.

MUTUALLY EXCLUSION OF PROJECTS OF DIFFERENT VALUES BY THE BENEFIT-COST METHOD

The recovery of an investment is very important in the world of economy. While businesses are preparing long-term projects for investment purposes, basic criteria such as changing economic conditions, risks, cash flows of the project, discount rate to be applied, economic life should be estimated in advance. For this reason, businesses prepare different projects that can provide the same economic conditions for the projects they prepare. In order to compare these projects, a cost-benefit table is prepared and evaluated in terms of their advantages. In line with these values, it is ensured that the most correct project is selected by eliminating each other. In this study, the cost-benefit ratio method was applied to three different projects. For all three projects, 10% annual interest and numerical values between 15 and 60 years of life are given. As a result of the evaluation of the projects, the most suitable project was determined by eliminating each other. Cash flows are calculated based on present and annual equivalents.