The Dark Side of Actin: Cardiac actin variants highlight the role of allostery in disease development

2020 ◽  
Vol 695 ◽  
pp. 108624
Author(s):  
Grace Zi Teng ◽  
John F. Dawson
Keyword(s):  
Dark Side ◽  
Disease Development ◽  
Cardiac Actin

STUDIES ON THE SEEDLING DISEASE OF BARLEY CAUSED BY HELMINTHOSPORIUM SATIVUM P.K. & B.

1956 ◽  
Vol 34 (4) ◽  
pp. 653-673 ◽  
Author(s):  
R. A. Ludwig ◽  
R. V. Clark ◽  
J. B. Julien ◽  
D. B. Robinson
Keyword(s):  
Disease Incidence ◽  
Infested Soil ◽  
Disease Development ◽  
Toxic Activity ◽  
Factors Affecting ◽  
Seedling Disease ◽  
Nutrient Salt ◽  
Helminthosporium Sativum ◽  
Treatment Comparisons

A standard sand – cornmeal – nutrient salt medium, for use in the production of artificial inoculum of Helminthosporium sativum, is described. This inoculum induces uniform plant disease development when thoroughly incorporated with the planting soil. The results presented clearly demonstrate the necessity of using a series of infestation levels in studies of factors affecting disease development in artificially infested soil. It is shown that considerable reliance can be placed on treatment comparisons within an experiment but that comparisons between experiments are much less accurate. The role of a toxin (or toxins) in disease development in barley seedlings has been demonstrated. The toxic activity was found to be distinct from that frequently encountered on addition of organic matter to soil. Results obtained suggest that toxin adsorption by the soil may play an important role in reducing disease incidence and severity.

scholarly journals Power Imbalance and the Dark Side of the Captive Agri-food Supplier–Buyer Relationship

2021 ◽  
Author(s):  
Richard Glavee-Geo ◽  
Per Engelseth ◽  
Arnt Buvik
Keyword(s):  
Financial Performance ◽  
Negative Impact ◽  
Positive Impact ◽  
Dark Side ◽  
Curvilinear Relationship ◽  
Power Imbalance ◽  
Negative Consequences ◽  
Key Informants ◽  
Economic Satisfaction

AbstractThis paper highlights the dark side of power imbalance regarding its consequences in agri-food supplier–buyer relationships. We report on findings from two studies. The first study is based on a sample of 105 key informants, while study 2 is based on a sample of 444 key informants, all from the cocoa agri-food supply market of Ghana. While the first study focuses on the antecedents of power imbalance and its consequences, the second study explores the role of cooperatives/collective action in minimizing supplier exploitation. Data from these studies were analysed using the partial least squares technique (SmartPLS). Analysis of these findings shows switching costs’ impact on power imbalance to be curvilinear, while power imbalance has a curvilinear relationship with opportunism. The negative consequences of power imbalance are further exacerbated by dependency and the lack of joint action. Furthermore, we found the negative impact of power imbalance on financial performance to be stronger for non-cooperative members than for cooperative members, while, counterintuitively, we found the positive impact of economic satisfaction on financial performance to be stronger for non-cooperative members than for cooperative members.

scholarly journals A Dual Role of Heme Oxygenase-1 in Cancer Cells

2018 ◽  
Vol 20 (1) ◽  
pp. 39 ◽  
Author(s):  
Shih-Kai Chiang ◽  
Shuen-Ei Chen ◽  
Ling-Chu Chang
Keyword(s):  
Cell Death ◽  
Heme Oxygenase ◽  
Cancer Progression ◽  
Critical Role ◽  
Causative Factor ◽  
Protective Role ◽  
Dark Side ◽  
Heme Oxygenase 1 ◽  
Cellular Iron

Heme oxygenase (HO)-1 is known to metabolize heme into biliverdin/bilirubin, carbon monoxide, and ferrous iron, and it has been suggested to demonstrate cytoprotective effects against various stress-related conditions. HO-1 is commonly regarded as a survival molecule, exerting an important role in cancer progression and its inhibition is considered beneficial in a number of cancers. However, increasing studies have shown a dark side of HO-1, in which HO-1 acts as a critical mediator in ferroptosis induction and plays a causative factor for the progression of several diseases. Ferroptosis is a newly identified iron- and lipid peroxidation-dependent cell death. The critical role of HO-1 in heme metabolism makes it an important candidate to mediate protective or detrimental effects via ferroptosis induction. This review summarizes the current understanding on the regulatory mechanisms of HO-1 in ferroptosis. The amount of cellular iron and reactive oxygen species (ROS) is the determinative momentum for the role of HO-1, in which excessive cellular iron and ROS tend to enforce HO-1 from a protective role to a perpetrator. Despite the dark side that is related to cell death, there is a prospective application of HO-1 to mediate ferroptosis for cancer therapy as a chemotherapeutic strategy against tumors.

Role of Stress and Psychosocial Determinants on Women's Cardiovascular Risk and Disease Development

2019 ◽  
Vol 28 (4) ◽  
pp. 483-489 ◽  
Author(s):  
Jose R. Medina-Inojosa ◽  
Shravya Vinnakota ◽  
Mariana Garcia ◽  
Maria Arciniegas Calle ◽  
Sharon L. Mulvagh ◽  
...  
Keyword(s):  
Cardiovascular Risk ◽  
Disease Development ◽  
Psychosocial Determinants

scholarly journals The Matrisome, Inflammation, and Liver Disease

2020 ◽  
Vol 40 (02) ◽  
pp. 180-188 ◽  
Author(s):  
Christine E. Dolin ◽  
Gavin E. Arteel
Keyword(s):  
Extracellular Matrix ◽  
Liver Disease ◽  
Fatty Liver ◽  
Chronic Liver Disease ◽  
Fatty Liver Disease ◽  
Chronic Liver ◽  
Disease Development ◽  
Disease States ◽  
Ecm Proteins

AbstractChronic fatty liver disease is common worldwide. This disease is a spectrum of disease states, ranging from simple steatosis (fat accumulation) to inflammation, and eventually to fibrosis and cirrhosis if untreated. The fibrotic stage of chronic liver disease is primarily characterized by robust accumulation of extracellular matrix (ECM) proteins (collagens) that ultimately impairs the function of the organ. The role of the ECM in early stages of chronic liver disease is less well-understood, but recent research has demonstrated that several changes in the hepatic ECM in prefibrotic liver disease are not only present but may also contribute to disease progression. The purpose of this review is to summarize the established and proposed changes to the hepatic ECM that may contribute to inflammation during earlier stages of disease development, and to discuss potential mechanisms by which these changes may mediate the progression of the disease.

scholarly journals Employee–Spouse Perceptual Congruence in Employee Work-to-Family Enrichment Affects Family and Work Outcomes: The Mediating Role of Relationship Conflict

2021 ◽  
Vol 12 ◽  
Author(s):  
Jianlan Chen ◽  
Yu Tian
Keyword(s):  
Emotional Exhaustion ◽  
Family Cohesion ◽  
Conflict Theory ◽  
Relationship Conflict ◽  
Work Outcomes ◽  
Dark Side ◽  
Mediating Role ◽  
Perceptual Congruence ◽  
Family Enrichment

Various studies have demonstrated that work-to-family enrichment (WFE) benefits employees in both the work and home domains. However, these findings may overstate the benefits of WFE and ignore its potential dark side. We advance the research on WFE by integrating conflict theory into the concept of WFE to investigate whether and how employee–spouse perceptual congruence in employee WFE influences employee family cohesion and emotional exhaustion. The results of polynomial regressions on 225 employee and spouse dyads revealed that the perceptual congruence in employee WFE between employees and spouses was negatively associated with relationship conflict. Additionally, asymmetrical incongruence effects were found, wherein spouses perceived a higher relationship conflict with employees when their perceptions of employee WFE were lower than those of the employees. Furthermore, spouses' perceived relationship conflict with employees mediated the influences of employee–spouse perceptual congruence in employee WFE on employee family cohesion and emotional exhaustion.

scholarly journals Parathyroid hormone-related protein as predictor of urolithiasis disease development

2020 ◽  
pp. 41-46
Author(s):  
A. A. Budanov ◽  
V. L. Medvedev ◽  
A. N. Kurzanov ◽  
A. A. Basov ◽  
G. A. Palaguta ◽  
...  
Keyword(s):  
Parathyroid Hormone ◽  
Surgical Treatment ◽  
Blood Parameters ◽  
Scientific Research Institute ◽  
Healthy People ◽  
Disease Development ◽  
Related Protein ◽  
Parathyroid Hormone Related Protein ◽  
Recurrent Nephrolithiasis

Background. The present article studies a possible role of parathyroid hormone-related protein (PTHrP) in urolithiasis pathogenesis.Aim. To consider PTHrP level as a predictor of the urolithiasis development.Material and methods. We presented an analysis of treatment in 79 patients with primary and recurrent nephrolithiasis that had underwent surgical treatment in the Uronephrological Center of Scientific Research Institute – Ochapovsky Regional Clinical Hospital #1, Krasnodar from 2017 to 2019. All observed patients were divided in two groups: patients with primary and recurrent nephrolithiasis. A group of 10 relatively healthy people was included in the study as well. All patients and conditionally healthy people had a test for blood parameters; in particular, the level of parathyroid hormone-related protein was assessed in order to compare the indicators in all three groups.Conclusions. The PTHrP level was showed to be statistically significantly different in patients with urolithiasis from the group with relatively healthy people. Groups with primary and recurrent nephrolithiasis show not difference in the level of PTHrP. Further studies are necessary to consider this protein as one of the predictors of urolithiasis and study its role in the pathogenesis of nephrolithiasis.

scholarly journals The Mediating Role of Employee Voice Behaviour in the Relation between Despotic Leadership and Employee Outcomes

sjesr ◽  
2020 ◽  
Vol 3 (4) ◽  
pp. 362-373
Author(s):  
Mir Aimal Kasi ◽  
Prof. Dr Zainiab Bibi ◽  
Prof. Dr Jahanvash Karim
Keyword(s):  
Turnover Intention ◽  
Positive Impact ◽  
Mediation Effect ◽  
Dark Side ◽  
Employee Voice ◽  
Voice Behavior ◽  
Employee Outcomes ◽  
Mediating Role ◽  
The Impact

Leaders play an essential role in the success and failure of the organization. In the past, studies examined positive leadership characteristics and behavior and their impacts on employee outcomes. The purpose of this study was to investigate the impact of despotic leadership on employee creativity and turnover intention with the mediating role of employee voice behavior. The sample consisted of 344 faculty members of Teacher Training Institutions in Pakistan. SPSS-25 software was used to evaluate the collected data. The results demonstrated that despotic leadership hurts employee voice behavior and creativity and has a positive impact on turnover intention. Further, the results also revealed that the voice behavior of employees has no mediation effect in the relationship between despotic leadership and employee outcomes (creativity and turnover intention). The study highlighted the importance of the topic and explored the research gap by focusing on the dark side of leadership and examined how despotic leadership harms the creativity and turnover intention of employees.

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