Cholestasis is a multifactorial disorder with various biological, infectious,
toxic, genetic and metabolic manifestations, its principal feature presented
as reduced bile flow or abnormalities in bile formation. It has lately been
accepted that some specific biological markers would shorten the period
needed to establish a positive diagnosis, as currently it is necessary to
navigate through a complex diagnostic protocol for this disorder. The
purpose of this study was to establish some biological parameters and
biomarkers useful for cholestasis management in children. Two hundred
thirty-two children with cholestasis were selected, during a six-year study.
The biological indicators followed were serum bilirubin, gamma-glutamyl
transpeptidase, aspartate transaminase, alkaline phosphatase, lactate
dehydrogenase, serum cholesterol and triglycerides. Our data showed that
certain biological parameters are more often involved in the various forms
of cholestasis, and the conclusions of this study could be useful in the
early detection of cholestasis and appropriate disease management.
Noval Dual-Emission Fluorescence Carbon Dots as a Ratiometric Probe for Cu2+ and ClO− Detection
