The efficacy of intra-articular lidocaine administration in chronic knee pain due to osteoarthritis: A randomized, double-blind, controlled study

2017 ◽  
Vol 36 (2) ◽  
pp. 109-114 ◽  
Author(s):  
H. Evren Eker ◽  
Oya Yalcin Cok ◽  
Anis Aribogan ◽  
Gulnaz Arslan
Keyword(s):  
Knee Pain ◽  
Controlled Study ◽  
Double Blind ◽  
Chronic Knee Pain ◽  
Lidocaine Administration

scholarly journals Ultrasound-Guided Genicular Nerve Pulsed Radiofrequency Treatment For Painful Knee Osteoarthritis: A Preliminary Report

2016 ◽  
Vol 5;19 (5;19) ◽  
pp. E751-E759 ◽  
Author(s):  
Dr. Serdar Kesikburun
Keyword(s):  
Knee Osteoarthritis ◽  
Knee Pain ◽  
Nerve Block ◽  
Study Design ◽  
Preliminary Report ◽  
Controlled Study ◽  
Pulsed Radiofrequency ◽  
Ultrasound Guided ◽  
Chronic Knee Pain ◽  
Pulsed Rf

Background: Genicular nerve ablation with radiofrequency (RF) has recently emerged as a promising treatment in the management of osteoarthritis related knee pain. To date, genicular nerve injections have been performed under fluoroscopic guidance. Objective: To evaluate the effect of ultrasound-guided genicular nerve pulsed RF treatment on chronic knee pain and function in patients with knee osteoarthritis. Study Design: Single-arm prospective study. Setting: University hospital and rehabilitation center in Turkey. Methods: A review was made of 29 patients with medial knee osteoarthritis who had undergone genicular nerve block in the previous 6 months. Patients with at least 50% reduction in the visual analog scale (VAS) score after genicular nerve block and with no on-going pain relief were selected for the study. Ultrasound-guided genicular nerve pulsed RF was applied to 15 knees of 9 patients. Pain and knee function were assessed with 100-mm VAS and Western Ontario and McMaster Universities (WOMAC) index throughout 3 months. Results: A significant reduction in VAS scores was detected over time after the pulsed RF procedure (f: 69.24, P < 0.01). There was a significant improvement in the WOMAC scores (f: 539.68 , P < 0.01). Limitations: The small number of participants, the lack of a control group, and short followup period were limitations of the study. Conclusions: Genicular nerve pulsed RF treatment has been found to be safe and beneficial in osteoarthritis related knee pain. Further studies with a larger population and randomized controlled study design are warranted to confirm the positive findings of this preliminary report. Key words: Knee pain, osteoarthritis, genicular nerve, ultrasonography, pulsed radiofrequency

The effectiveness of pulsed ultrasound treatment on pain, function, synovial sac thickness and femoral cartilage thickness in patients with knee osteoarthritis: a randomized, double-blind clinical, controlled study

2020 ◽  
Vol 34 (12) ◽  
pp. 1474-1484
Author(s):  
Ali Karakaş ◽  
Banu Dilek ◽  
M Abdulkerim Şahin ◽  
Hülya Ellidokuz ◽  
Özlem Şenocak
Keyword(s):  
Knee Osteoarthritis ◽  
Knee Pain ◽  
Controlled Study ◽  
Pulsed Ultrasound ◽  
Timed Up And Go ◽  
Double Blind ◽  
Femoral Cartilage ◽  
Group I ◽  
Group Ii ◽  
Pain At Rest

Objective: This study aims to investigate the efficacy of therapeutic pulsed ultrasound on pain, function, synovial sac and femoral cartilage in knee osteoarthritis. Design: Randomized, double-blind, controlled study Setting: Dokuz Eylul University, Department of Physical Medicine and Rehabilitation Subjects: A total of 96 patients with knee osteoarthritis Interventions: Participants were randomized into two groups; Group I ( n = 48, pulsed ultrasound) and Group II ( n = 48, sham ultrasound). The sessions were held three times a week for 8 weeks. The study continued for 12 weeks (with 4 weeks follow-up). All participants performed exercises at home for 12 weeks. Main measures: Knee pain (at rest and ADLs) was assessed using the visual analog scale (VAS). Functionality was assessed using the Timed Up and Go test and Western Ontario and McMaster Universities Osteoarthritis (WOMAC) questionnaire. Femoral cartilage and synovial sac thickness was measured using ultrasonography. All evaluations were performed at the baseline, at the 8 and 12 weeks after baseline. Results: The study was completed with a total of 75 patients ( n = 39 in group I and n = 36 in group II). The mean (SD) pain at ADLs score at baseline and week 12 was 7.2 (2.1), with 3.6 (2.9) in the group I, and 6.7 (2.0) and 4.3 (2.2) in the group II, respectively. Both groups presented significant improvements in terms of pain and function ( P < 0.001). There was no difference between groups for any parameters. Conclusion: Treatment of pulsed ultrasound has no positive effect on knee pain, function, femoral cartilage and synovial sac thickness in knee osteoarthritis.

The Effects of a Topical Analgesic and Placebo in Treatment of Chronic Knee Pain

2004 ◽  
Vol 12 (2) ◽  
pp. 199-213 ◽  
Author(s):  
J. William Myrer ◽  
J. Brent Feland ◽  
Gilbert W. Fellingham
Keyword(s):  
Knee Pain ◽  
Pain Scale ◽  
Controlled Clinical Trial ◽  
Old People ◽  
Double Blind ◽  
Pain Scores ◽  
Chronic Knee Pain ◽  
Active Range Of Motion ◽  
Dependent Variables ◽  
Topical Analgesic

Chronic knee pain is a prevalent health problem of old and middle age. The authors’ objective was to determine whether a topical analgesic would reduce knee pain and improve the function of a group of 40- to 65-year-old people with chronic knee pain. The experimental design was a double-blind, randomized, placebo-controlled clinical trial. The dependent variables were knee pain, active range of motion, and isometric strength. Forty-six men and women volunteered, of whom 3 dropped out, leaving 23 in the treatment group and 20 in the placebo group. Knee pain was assessed with a visual analogue scale and the knee-pain scale for frequency and severity. Testing took place before treatment and after 21 and 35 days of treatment. The results indicated that although both groups experienced improved pain scores, there were no differences between groups over the treatment period for any of the dependent variables.

scholarly journals An Investigation into the Effects of a Curcumin Extract (Curcugen®) on Osteoarthritis Pain of the Knee: A Randomised, Double-Blind, Placebo-Controlled Study

Nutrients ◽  
2021 ◽  
Vol 14 (1) ◽  
pp. 41
Author(s):  
Adrian L. Lopresti ◽  
Stephen J. Smith ◽  
Shavon Jackson-Michel ◽  
Timothy Fairchild
Keyword(s):  
Outcome Measures ◽  
Knee Pain ◽  
Controlled Study ◽  
Walk Test ◽  
Timed Up And Go ◽  
Double Blind ◽  
Double Blind Placebo ◽  
Chair Stand ◽  
Stand Test ◽  
Pain Ratings

Curcumin, a phytochemical from the spice turmeric, has anti-inflammatory properties and has been shown to have pain-relieving effects. In this 8-week, randomised, double-blind, placebo-controlled study, 101 adults with knee osteoarthritis received either 500 mg twice daily of a standardised curcumin extract (Curcugen®) or placebo. Outcome measures included the Knee Injury and Osteoarthritis Outcome Score (KOOS), knee pain ratings, Japanese Orthopaedic Association Score for Osteoarthritic Knees (JOA), PROMIS–29, and performance-based testing comprising the 40-m fast-paced walk test, 6-min walk test, timed up-and-go test, and 30-s chair stand test. Compared to the placebo, curcumin significantly reduced the KOOS knee pain score (p = 0.009) and numeric knee pain ratings (p = 0.001). Curcumin was also associated with greater improvements (p ≤ 0.05) than the placebo on the timed up-and-go test, 6-min walk test, and the JOA total score; but not the 30-s chair stand test or 40-m fast-paced walk test. Pain-relieving medication was reduced in 37% of participants on curcumin compared to 13% on placebo. The findings support the potential efficacy of curcumin for the treatment of osteoarthritis of the knee but studies of longer duration, varying treatment doses, differing curcumin extracts, and the use of other objective outcome measures will be helpful to expand on these findings.

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