Feasibility of Predicting Pelvic Lymph Node Metastasis Based on IVIM-DWI and Texture Parameters of the Primary Lesion and Lymph Nodes in Patients with Cervical Cancer

2021 ◽  
Author(s):  
Yu Zhang ◽  
Kai-yue Zhang ◽  
Hao-dong Jia ◽  
Xin Fang ◽  
Ting-ting Lin ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Lymph Node ◽  
Lymph Node Metastasis ◽  
Lymph Nodes ◽  
Primary Lesion ◽  
Pelvic Lymph Node ◽  
Node Metastasis ◽  
Pelvic Lymph Node Metastasis ◽  
Texture Parameters

Effect of radiotherapy on pelvic lymph node metastasis in cervical cancer stages IB2–IVA: a retrospective analysis of two comparative series

2005 ◽  
Vol 15 (3) ◽  
pp. 468-474
Author(s):  
D. Dargent ◽  
G. Lamblin ◽  
P. Romestaing ◽  
X. Montbarbon ◽  
P. Mathevet ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Lymph Node ◽  
Lymph Node Metastasis ◽  
Lymph Nodes ◽  
Pelvic Lymph Node ◽  
Tumor Diameter ◽  
Pelvic Radiotherapy ◽  
Node Metastasis ◽  
Pelvic Lymph Node Metastasis ◽  
Two Populations

Efficiency of radiotherapy in controlling lymph node metastasis is a controversial issue. A continuous series of 87 patients affected by cervical cancer stages IB2–IVA and treated using pelvic radiotherapy is presented. A retrospective comparison is made between two populations. In the two populations, a staging lymphadenectomy was carried out before the onset of the therapeutic program. In the first population (53 patients), the pelvic nodes only were dissected and in the second one (34 patients), the pelvic lymph nodes were left in place and the paraaortic nodes only were dissected. In both series, a completion surgery was performed after finalization of the radiotherapy. It was carried out at open abdomen in both series. It included a systematic pelvic dissection for the patients whose pelvic nodes had been intentionally left in place at the time of the initial staging lymphadenectomy. Both series were identical as far as classic risk factors were concerned (FIGO stage, maximal tumor diameter, lymphovascular space involvement). The radiotherapy administered to the pelvis was the same in both populations. The number of patients with pelvic lymph node metastasis was 21 (39.6%) in the first population versus 6 (17.6%) in the second one (P = 0.03). The percentage of positive lymph nodes among the retrieved lymph nodes was 18.94 in the first population versus 2.8 in the second one (P = 0.0001). Pelvic radiotherapy is likely to control most of the pelvic lymph node metastasis, but not all of them. Practical deductions and further developments are discussed.

Effect of Nano-Tracer on Identification of Sentinel Lymph Nodes in Pelvic Cavity and Postoperative Complications in Patients with Cervical Cancer

2021 ◽  
Vol 21 (2) ◽  
pp. 971-976
Author(s):  
Juanjuan Jin ◽  
Zhimin Liu ◽  
Yanhui Chen
Keyword(s):  
Cervical Cancer ◽  
Lymph Node ◽  
Postoperative Complications ◽  
Lymph Node Metastasis ◽  
Lymph Nodes ◽  
Sentinel Lymph Nodes ◽  
Pelvic Lymph Node ◽  
Node Metastasis ◽  
Pelvic Lymph Node Metastasis ◽  
The Impact

Cervical cancer is the most common malignant tumor of the female reproductive system. Its incidence rate ranks first among female malignant tumors in China and has been increasing in recent years. However, pelvic lymph node metastasis is an important factor affecting the prognosis of cervical cancer, because pelvic lymph node metastasis determines the scope of surgery, it is also an important basis for postoperative adjuvant treatment. Therefore, an accurate and effective method is needed to detect the presence of lymphatic metastases in time to guide the need for systematic pelvic lymph node dissection. This article explores the clinical application of nano-tracer in the surgical treatment of cervical cancer patients and the impact of postoperative complications on patients with pelvic sentinel lymph nodes. The results show that the success rate of sentinel lymph node tracing in cervical cancer surgery is high, and it is a safe and efficient lymph tracer, which can provide an effective way to study cervical micro metastasis and lymphatic chemotherapy.

Basement Membranes in Cervical Cancer: Relationship to Pelvic Lymph Node Metastasis and Prognosis

1995 ◽  
Vol 57 (3) ◽  
pp. 351-355 ◽  
Author(s):  
G.L. Bremer ◽  
A.T.M.G. Tiebosch ◽  
H.W.H.M. van der Putten ◽  
J. de Haan ◽  
J.W. Arends
Keyword(s):  
Cervical Cancer ◽  
Lymph Node ◽  
Lymph Node Metastasis ◽  
Basement Membranes ◽  
Pelvic Lymph Node ◽  
Node Metastasis ◽  
Pelvic Lymph Node Metastasis

Identification of risk factors associated with pelvic lymph node metastasis in patients with stage IB1 cervical cancer.

2020 ◽  
Vol 38 (15_suppl) ◽  
pp. e18005-e18005
Author(s):  
Ping Jiang ◽  
Jing Cai ◽  
Xiaoqi He ◽  
Hongbo Wang ◽  
Weihong Dong ◽  
...  
Keyword(s):  
Risk Factors ◽  
Cervical Cancer ◽  
Lymph Node ◽  
Lymph Node Metastasis ◽  
Lymph Nodes ◽  
Tumor Size ◽  
Node Metastasis ◽  
Parametrial Invasion ◽  
Pelvic Lymph Node Metastasis ◽  
Internal Iliac

e18005 Background: Evaluation the distribution of nodal metastases in the stage IB1 cervical cancer and the risk factors associated with pelvic lymph node metastasis (LNM) at each anatomic location. Methods: 728 patients with stage IB1 cervical cancer who underwent radical hysterectomies and systemic pelvic lymphadenectomies from January 2008 to December 2017 were retrospectively studied. All removed pelvic lymph nodes were pathologically examined, and the risk factors for LNM at the obturator, internal iliac, external iliac, and common iliac regions were evaluated by univariate and multivariate logistic regression analyses. Results: 20,134 lymph nodes were analysed with the average number of 27.80 (± SD 9.43) lymph nodes per patient. Nodal metastases were present in 266 (14.6%) patients. The obturator was the most common site for nodal metastasis (42.5%) followed by the internal iliac nodes (20.3%) and the external iliac nodes (19.9%), while the common iliac (9.8%) and parametrial (7.5%) nodes were the least likely to be involved. Tumor size more than 2 cm, histologically proven lymphovascular space involvement (LVSI) and parametrial invasion correlated independently significantly with the higher risk of the lymphatic metastasis. Obesity (BMI≥25) was independently significantly negatively correlated with the risk of lymphatic metastases. All the positive common iliac nodes were found in patients with tumors greater than 2 cm. The multivariate analysis showed that tumor size greater than 3 cm was associated with a 16.6-fold increase in the risk for common iliac LNM. Interestingly, tumor size was not an independent risk factor for pelvic LNM in the lower regions, i.e., the obturator, internal iliac and external iliac areas, where LVSI was the most significant predictor for LNM. In addition, parametrial invasion was related to external and internal iliac LNM; deep stromal invasion and age less than 50 years were associated with obturator LNM. Conclusions: The incidence of lymph node metastasis in patients with stage IB1 cervical cancer is low but prognostically relevant. The data offer the opportunity for tailored individual treatment in selected patients with small tumors and obesity.

scholarly journals Expression of Fas Ligand is Higher in Early Stage Cervical Cancer with Lymph Nodes Metastasis

2016 ◽  
Author(s):  
Yahya Irwanto
Keyword(s):  
Cervical Cancer ◽  
Lymph Node ◽  
Lymph Node Metastasis ◽  
Radical Hysterectomy ◽  
Fas Ligand ◽  
Pelvic Lymph Node ◽  
Lymph Nodes Metastasis ◽  
Node Metastasis ◽  
Pelvic Lymph Node Metastasis ◽  
Spearman Test

Objective: To know whether the expression of Fas Ligand has correlation with incidene of metastasis of pelvic lymph node and lymph-vascular stromal invasion (LVSI). Methods: All patients diagnosed of cervical cancer stage IB or IIA who underwent radical hysterectomy in Dr. Cipto Mangunkusumo Central General Hospital from January 2008 until December 2009 were included in analytic cross sectional study. We tested expression of Fas Ligand in cervical cancer specimen by immunohystochemistry with monoclonal antibody. The expression of Fas Ligand was compared between the group of patients with a positive and negative pelvic lymph node and between LVSI positive and negative. The difference of expression in both group were statistically analized with Chi-square test and the correlation Spearman test. Result: Ninety one patients underwent radical hysterectomy for two years and 43 patients were included in these study. The expression of Fas Ligand in 7 patients (16.3%) were negative and the others were positive, with weak, moderate and strong expression were 4 (9.3%), 27 (62.8%), and 5 (11.6%) respectively. The expression of Fas Ligand was significantly higher in the group of patients with positive pelvic lymph node compared to the group of the patients with negative pelvic lymph node (p=0.007) but there was no significant difference between group of the patients with LVSI positive and negative. With Spearman test, we found that the expression of Fas Ligand had a strong correlation with pelvic lymph nodes metastasis (coeff. correlation=0.519 and p=0.00) and have no correlation with LVSI (coef. corellation=0.112 and p=0.474). Conclusion: These finding suggested that expression of Fas Ligand in cervical cancer patients has a strong correlation with the incidence of pelvic lymph node metastasis and none with LVSI. [Indones J Obstet Gynecol 2012; 36-4: 194-9] Keywords: cervical cancer, fas ligand, immunohystochemistry, LVSI, pelvic lymph node metastasis

Pelvic lymph node metastasis of uterine cervical cancer

1987 ◽  
Vol 27 (2) ◽  
pp. 150-158 ◽  
Author(s):  
Hiroshi Noguchi ◽  
Isao Shiozawa ◽  
Yoshikimi Sakai ◽  
Teruyuki Yamazaki ◽  
Toru Fukuta
Keyword(s):  
Cervical Cancer ◽  
Lymph Node ◽  
Lymph Node Metastasis ◽  
Uterine Cervical Cancer ◽  
Pelvic Lymph Node ◽  
Node Metastasis ◽  
Pelvic Lymph Node Metastasis
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