Enzyme-responsive multifunctional peptide coating of gold nanorods improves tumor targeting and photothermal therapy efficacy

2019 ◽  
Vol 86 ◽  
pp. 363-372 ◽  
Author(s):  
Liming Wu ◽  
Bingyi Lin ◽  
Huang Yang ◽  
Jing Chen ◽  
Zhengwei Mao ◽  
...  
Keyword(s):  
Gold Nanorods ◽  
Photothermal Therapy ◽  
Tumor Targeting ◽  
Therapy Efficacy ◽  
Peptide Coating

scholarly journals Gold Nanorod Bioconjugates for Active Tumor Targeting and Photothermal Therapy

2011 ◽  
Vol 2011 ◽  
pp. 1-7 ◽  
Author(s):  
Hadiyah N. Green ◽  
Dmitry V. Martyshkin ◽  
Cynthia M. Rodenburg ◽  
Eben L. Rosenthal ◽  
Sergey B. Mirov
Keyword(s):  
Gold Nanoparticles ◽  
Gold Nanorods ◽  
Photothermal Therapy ◽  
Tumor Targeting ◽  
Near Infrared ◽  
Malignant Tumors ◽  
Photothermal Effect ◽  
Specific Antibodies ◽  
Before And After ◽  
Egfr Antibody

The mastery of active tumor targeting is a great challenge in near infrared photothermal therapy (NIRPTT). To improve efficiency for targeted treatment of malignant tumors, we modify the technique of conjugating gold nanoparticles to tumor-specific antibodies. Polyethylene glycol-coated (PEGylated) gold nanorods (GNRs) were fabricated and conjugated to an anti-EGFR antibody. We characterized the conjugation efficiency of the GNRs by comparing the efficiency of antibody binding and the photothermal effect of the GNRs before and after conjugation. We demonstrate that the binding efficiency of the antibodies conjugated to the PEGylated GNRs is comparable to the binding efficiency of the unmodified antibodies and 33.9% greater than PEGylated antibody-GNR conjugates as reported by Liao and Hafner (2005). In addition, cell death by NIRPTT was sufficient to kill nearly 90% of tumor cells, which is comparable to NIRPTT with GNRs alone confirming that NIRPTT using GNRs is not compromised by conjugation of GNRs to antibodies.

RGD-Conjugated Dendrimer-Modified Gold Nanorods for in Vivo Tumor Targeting and Photothermal Therapy

2009 ◽  
Vol 7 (1) ◽  
pp. 94-104 ◽  
Author(s):  
Zhiming Li ◽  
Peng Huang ◽  
Xuejun Zhang ◽  
Jing Lin ◽  
Sen Yang ◽  
...  
Keyword(s):  
Gold Nanorods ◽  
Photothermal Therapy ◽  
Tumor Targeting

scholarly journals Delivery of siRNA Using Functionalized Gold Nanorods Enhances Anti-Osteosarcoma Efficacy

2021 ◽  
Vol 12 ◽  
Author(s):  
Man Zhang ◽  
Jinti Lin ◽  
Jiakang Jin ◽  
Wei Yu ◽  
Yiying Qi ◽  
...  
Keyword(s):  
Gold Nanorods ◽  
Photothermal Therapy ◽  
Tumor Targeting ◽  
Tumor Treatment ◽  
Targeting Therapy ◽  
Cell Penetrating ◽  
Transcription Factor Eb ◽  
Membrane Peptide ◽  
Targeting Ability ◽  
Risk Of Relapse

Gold nanorods (GNRs) are intensively explored for the application in cancer therapy, which has motivated the development of photothermal therapy (PTT) multifunctional nanoplatforms based on GNRs to cure osteosarcoma (OS). However, the major limitations include the toxicity of surface protectants of GNRs, unsatisfactory targeting therapy, and the resistant effects of photothermal-induced autophagy, so the risk of relapse and metastasis of OS increase. In the present study, the GNR multifunctional nanoplatforms were designed and synthesized to deliver transcription factor EB (TFEB)-siRNA–targeting autophagy; then, the resistance of autophagy to PTT and the pH-sensitive cell-penetrating membrane peptide (CPP) was weakened, which could improve the tumor-targeting ability of the GNR nanoplatforms and realize an efficient synergistic effect for tumor treatment. Meanwhile, it is worth noting that the GNR nanoplatform groups have anti-lung metastasis of OS. This study provides a new reference to improve the efficacy of OS clinically.

12P-Conjugated PEG-Modified Gold Nanorods Combined with Near-Infrared Laser for Tumor Targeting and Photothermal Therapy

2012 ◽  
Vol 12 (9) ◽  
pp. 7198-7205 ◽  
Author(s):  
Tao Zhan ◽  
Pengfei Li ◽  
Shan Bi ◽  
Biao Dong ◽  
Hongwei Song ◽  
...  
Keyword(s):  
Gold Nanorods ◽  
Photothermal Therapy ◽  
Tumor Targeting ◽  
Near Infrared ◽  
Infrared Laser

scholarly journals Novel albumin-binding photothermal agent ICG-IBA-RGD for targeted fluorescent imaging and photothermal therapy of cancer

RSC Advances ◽  
2021 ◽  
Vol 11 (13) ◽  
pp. 7226-7230
Author(s):  
Cheng Yu ◽  
Enhua Xiao ◽  
Pengfei Xu ◽  
Jingjing Lin ◽  
Linan Hu ◽  
...  
Keyword(s):  
Photothermal Therapy ◽  
Tumor Targeting ◽  
Fluorescent Imaging ◽  
Albumin Binding

In this work, we present a novel photothermal agent ICG-IBA-RGD based on albumin-binding strategy for enhanced tumor targeting imaging and photothermal therapy.

Aptamer and RVG functionalized gold nanorods for targeted photothermal therapy of neurotropic virus infection in the mouse brain

2021 ◽  
Vol 411 ◽  
pp. 128557
Author(s):  
Meishen Ren ◽  
Jiaojiao Zhou ◽  
Zhiyong Song ◽  
Hong Mei ◽  
Ming Zhou ◽  
...  
Keyword(s):  
Virus Infection ◽  
Mouse Brain ◽  
Gold Nanorods ◽  
Photothermal Therapy ◽  
Neurotropic Virus
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