Gold nanorods conjugated with biocompatible zwitterionic polypeptide for combined chemo-photothermal therapy of cervical cancer

2021 ◽  
pp. 112014
Author(s):  
Shuang-hui Huang ◽  
Si Peng ◽  
Qiu-yue Wang ◽  
Qiu-hui Hu ◽  
Run-qin Zhang ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Gold Nanorods ◽  
Photothermal Therapy

Human Induced Pluripotent Stem Cells for Tumor Targeted Delivery of Gold Nanorods and Enhanced Photothermal Therapy

ACS Nano ◽  
2016 ◽  
Vol 10 (2) ◽  
pp. 2375-2385 ◽  
Author(s):  
Yanlei Liu ◽  
Meng Yang ◽  
Jingpu Zhang ◽  
Xiao Zhi ◽  
Chao Li ◽  
...  
Keyword(s):  
Stem Cells ◽  
Induced Pluripotent Stem Cells ◽  
Gold Nanorods ◽  
Pluripotent Stem Cells ◽  
Targeted Delivery ◽  
Photothermal Therapy ◽  
Induced Pluripotent

Aptamer and RVG functionalized gold nanorods for targeted photothermal therapy of neurotropic virus infection in the mouse brain

2021 ◽  
Vol 411 ◽  
pp. 128557
Author(s):  
Meishen Ren ◽  
Jiaojiao Zhou ◽  
Zhiyong Song ◽  
Hong Mei ◽  
Ming Zhou ◽  
...  
Keyword(s):  
Virus Infection ◽  
Mouse Brain ◽  
Gold Nanorods ◽  
Photothermal Therapy ◽  
Neurotropic Virus

Pillar[5]arene‐Modified Gold Nanorods as Nanocarriers for Multi‐Modal Imaging‐Guided Synergistic Photodynamic‐Photothermal Therapy

2021 ◽  
pp. 2009924
Author(s):  
Nan Song ◽  
Zhijun Zhang ◽  
Peiying Liu ◽  
Dihua Dai ◽  
Chao Chen ◽  
...  
Keyword(s):  
Gold Nanorods ◽  
Photothermal Therapy

scholarly journals Photothermal Therapy Using Gold Nanorods and Near-Infrared Light in a Murine Melanoma Model Increases Survival and Decreases Tumor Volume

2014 ◽  
Vol 2014 ◽  
pp. 1-8 ◽  
Author(s):  
Mary K. Popp ◽  
Imane Oubou ◽  
Colin Shepherd ◽  
Zachary Nager ◽  
Courtney Anderson ◽  
...  
Keyword(s):  
Light Source ◽  
Gold Nanorods ◽  
Photothermal Therapy ◽  
Near Infrared ◽  
Tumor Volume ◽  
Infrared Light ◽  
Led Light ◽  
Murine Melanoma ◽  
Nir Light ◽  
Melanoma Model

Photothermal therapy (PTT) treatments have shown strong potential in treating tumors through their ability to target destructive heat preferentially to tumor regions. In this paper we demonstrate that PTT in a murine melanoma model using gold nanorods (GNRs) and near-infrared (NIR) light decreases tumor volume and increases animal survival to an extent that is comparable to the current generation of melanoma drugs. GNRs, in particular, have shown a strong ability to reach ablative temperatures quickly in tumors when exposed to NIR light. The current research tests the efficacy of GNRs PTT in a difficult and fast growing murine melanoma model using a NIR light-emitting diode (LED) light source. LED light sources in the NIR spectrum could provide a safer and more practical approach to photothermal therapy than lasers. We also show that the LED light source can effectively and quickly heatin vitroandin vivomodels to ablative temperatures when combined with GNRs. We anticipate that this approach could have significant implications for human cancer therapy.

Corrigendum: Near‐infrared emissive polymer‐coated IR‐820 nanoparticles assisted photothermal therapy for cervical cancer cells

2022 ◽  
Author(s):  
Lijun Zhu ◽  
Jianjun Chen ◽  
Ting Yan ◽  
Gulinigaer Alimu ◽  
Xueliang Zhang ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Cancer Cells ◽  
Photothermal Therapy ◽  
Near Infrared ◽  
Cervical Cancer Cells

scholarly journals A Novel Fast Photothermal Therapy Using Hot Spots of Gold Nanorods for Malignant Melanoma Cells

Nanomaterials ◽  
2018 ◽  
Vol 8 (11) ◽  
pp. 880 ◽  
Author(s):  
Yanhua Yao ◽  
Nannan Zhang ◽  
Xiao Liu ◽  
Qiaofeng Dai ◽  
Haiying Liu ◽  
...  
Keyword(s):  
Cell Death ◽  
Malignant Melanoma ◽  
Gold Nanorods ◽  
Plasmon Resonance ◽  
Photothermal Therapy ◽  
Treatment Time ◽  
High Energy ◽  
Melanoma Cells ◽  
Photothermal Effect ◽  
A375 Cells

In this paper, the plasmon resonance effects of gold nanorods was used to achieve rapid photothermal therapy for malignant melanoma cells (A375 cells). After incubation with A375 cells for 24 h, gold nanorods were taken up by the cells and gold nanorod clusters were formed naturally in the organelles of A375 cells. After analyzing the angle and space between the nanorods in clusters, a series of numerical simulations were performed and the results show that the plasmon resonance coupling between the gold nanorods can lead to a field enhancement of up to 60 times. Such high energy localization causes the temperature around the nanorods to rise rapidly and induce cell death. In this treatment, a laser as low as 9.3 mW was used to irradiate a single cell for 20 s and the cell died two h later. The cell death time can also be controlled by changing the power of laser which is focused on the cells. The advantage of this therapy is low laser treatment power, short treatment time, and small treatment range. As a result, the damage of the normal tissue by the photothermal effect can be greatly avoided.

Magnetic Supramolecular Nanofibers of Gold Nanorods for Photothermal Therapy

2018 ◽  
Vol 2 (4) ◽  
pp. 1800137 ◽  
Author(s):  
Qilin Yu ◽  
Ying‐Ming Zhang ◽  
Yao‐Hua Liu ◽  
Yu Liu
Keyword(s):  
Gold Nanorods ◽  
Photothermal Therapy

Polypeptide-Engineered Hydrogel Coated Gold Nanorods for Targeted Drug Delivery and Chemo-photothermal Therapy

2017 ◽  
Vol 3 (10) ◽  
pp. 2391-2398 ◽  
Author(s):  
Jie Yang ◽  
Ming-Hao Yao ◽  
Rui-Mei Jin ◽  
Dong-Hui Zhao ◽  
Yuan-Di Zhao ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Gold Nanorods ◽  
Targeted Drug Delivery ◽  
Photothermal Therapy ◽  
Targeted Drug

scholarly journals Gold Nanorods for Light-Based Lung Cancer Theranostics

2018 ◽  
Vol 19 (11) ◽  
pp. 3318 ◽  
Author(s):  
Oscar Knights ◽  
James McLaughlan
Keyword(s):  
Gold Nanorods ◽  
Photothermal Therapy ◽  
Continuous Wave ◽  
Low Cost ◽  
Laser System ◽  
Controlled Synthesis ◽  
Surface Plasmon Resonances ◽  
Plasmon Resonances ◽  
Theranostic Applications ◽  
Cancer Theranostics

Gold nanorods (AuNRs) have the potential to be used in photoacoustic (PA) imaging and plasmonic photothermal therapy (PPTT) due to their unique optical properties, biocompatibility, controlled synthesis, and tuneable surface plasmon resonances (SPRs). Conventionally, continuous-wave (CW) lasers are used in PPTT partly due to their small size and low cost. However, if pulsed-wave (PW) lasers could be used to destroy tissue then combined theranostic applications, such as PA-guided PPTT, would be possible using the same laser system and AuNRs. In this study, we present the effects of AuNR size on PA response, PW-PPTT efficacy, and PA imaging in a tissue-mimicking phantom, as a necessary step in the development of AuNRs towards clinical use. At equivalent NP/mL, the PA signal intensity scaled with AuNR size, indicating that overall mass has an effect on PA response, and reinforcing the importance of efficient tumour targeting. Under PW illumination, all AuNRs showed toxicity at a laser fluence below the maximum permissible exposure to skin, with a maximum of 80% cell-death exhibited by the smallest AuNRs, strengthening the feasibility of PW-PPTT. The theranostic potential of PW lasers combined with AuNRs has been demonstrated for application in the lung.

Sign in / Sign up

Export Citation Format

Share Document