scholarly journals Delivery of siRNA Using Functionalized Gold Nanorods Enhances Anti-Osteosarcoma Efficacy

2021 ◽  
Vol 12 ◽  
Author(s):  
Man Zhang ◽  
Jinti Lin ◽  
Jiakang Jin ◽  
Wei Yu ◽  
Yiying Qi ◽  
...  
Keyword(s):  
Gold Nanorods ◽  
Photothermal Therapy ◽  
Tumor Targeting ◽  
Tumor Treatment ◽  
Targeting Therapy ◽  
Cell Penetrating ◽  
Transcription Factor Eb ◽  
Membrane Peptide ◽  
Targeting Ability ◽  
Risk Of Relapse

Gold nanorods (GNRs) are intensively explored for the application in cancer therapy, which has motivated the development of photothermal therapy (PTT) multifunctional nanoplatforms based on GNRs to cure osteosarcoma (OS). However, the major limitations include the toxicity of surface protectants of GNRs, unsatisfactory targeting therapy, and the resistant effects of photothermal-induced autophagy, so the risk of relapse and metastasis of OS increase. In the present study, the GNR multifunctional nanoplatforms were designed and synthesized to deliver transcription factor EB (TFEB)-siRNA–targeting autophagy; then, the resistance of autophagy to PTT and the pH-sensitive cell-penetrating membrane peptide (CPP) was weakened, which could improve the tumor-targeting ability of the GNR nanoplatforms and realize an efficient synergistic effect for tumor treatment. Meanwhile, it is worth noting that the GNR nanoplatform groups have anti-lung metastasis of OS. This study provides a new reference to improve the efficacy of OS clinically.

Application of Gold-Based Nanomaterials in Tumor Photothermal Therapy and Chemotherapy

2020 ◽  
Vol 16 (6) ◽  
pp. 739-762
Author(s):  
Minyu Zhou ◽  
Yunfei Zhou ◽  
Yixin Cheng ◽  
Yanqi Wu ◽  
Jun Yang ◽  
...  
Keyword(s):  
Photothermal Therapy ◽  
Tumor Targeting ◽  
Tumor Tissue ◽  
Treatment Method ◽  
Tumor Treatment ◽  
Targeting Therapy ◽  
Photothermal Conversion ◽  
Gold Nanomaterials ◽  
Development Prospects ◽  
Therapy Treatment

Photothermal therapy (PTT) is a minimally invasive tumor treatment method in which photothermal conversion agents (PTAs) can be enriched in tumor tissue by external light stimulation to convert photon energy into thermal energy to induce the temperature of tumor tissue higher than normal physiological, and can effectively kill tumor cells and tissues while avoiding damage to healthy tissue. As a well-known biocompatible nanomaterial, gold-based nanomaterials have high photothermal conversion efficiency and cross section, which can be used in tumor targeting therapy treatment as a potential photothermal conversion agent. Combining PTT and chemotherapy can be achieved by loading a chemotherapeutic drug modified on the surface of a gold nanomaterials. Therefore, this paper first reviews the preparation and surface functionalization of Au-based nanomaterials, such as Au nanorods, Au nanostars, Au nanoshells, and so on. Second, we have also introduced the application of Au-based nanomaterials in PTT, chemotherapy, and combination therapy. Finally, the limitations and challenges of Au-based photothermal conversion agents are summarized and the development prospects in this field are prospected.

Enzyme-responsive multifunctional peptide coating of gold nanorods improves tumor targeting and photothermal therapy efficacy

2019 ◽  
Vol 86 ◽  
pp. 363-372 ◽  
Author(s):  
Liming Wu ◽  
Bingyi Lin ◽  
Huang Yang ◽  
Jing Chen ◽  
Zhengwei Mao ◽  
...  
Keyword(s):  
Gold Nanorods ◽  
Photothermal Therapy ◽  
Tumor Targeting ◽  
Therapy Efficacy ◽  
Peptide Coating

scholarly journals Gold Nanorod Bioconjugates for Active Tumor Targeting and Photothermal Therapy

2011 ◽  
Vol 2011 ◽  
pp. 1-7 ◽  
Author(s):  
Hadiyah N. Green ◽  
Dmitry V. Martyshkin ◽  
Cynthia M. Rodenburg ◽  
Eben L. Rosenthal ◽  
Sergey B. Mirov
Keyword(s):  
Gold Nanoparticles ◽  
Gold Nanorods ◽  
Photothermal Therapy ◽  
Tumor Targeting ◽  
Near Infrared ◽  
Malignant Tumors ◽  
Photothermal Effect ◽  
Specific Antibodies ◽  
Before And After ◽  
Egfr Antibody

The mastery of active tumor targeting is a great challenge in near infrared photothermal therapy (NIRPTT). To improve efficiency for targeted treatment of malignant tumors, we modify the technique of conjugating gold nanoparticles to tumor-specific antibodies. Polyethylene glycol-coated (PEGylated) gold nanorods (GNRs) were fabricated and conjugated to an anti-EGFR antibody. We characterized the conjugation efficiency of the GNRs by comparing the efficiency of antibody binding and the photothermal effect of the GNRs before and after conjugation. We demonstrate that the binding efficiency of the antibodies conjugated to the PEGylated GNRs is comparable to the binding efficiency of the unmodified antibodies and 33.9% greater than PEGylated antibody-GNR conjugates as reported by Liao and Hafner (2005). In addition, cell death by NIRPTT was sufficient to kill nearly 90% of tumor cells, which is comparable to NIRPTT with GNRs alone confirming that NIRPTT using GNRs is not compromised by conjugation of GNRs to antibodies.

RGD-Conjugated Dendrimer-Modified Gold Nanorods for in Vivo Tumor Targeting and Photothermal Therapy

2009 ◽  
Vol 7 (1) ◽  
pp. 94-104 ◽  
Author(s):  
Zhiming Li ◽  
Peng Huang ◽  
Xuejun Zhang ◽  
Jing Lin ◽  
Sen Yang ◽  
...  
Keyword(s):  
Gold Nanorods ◽  
Photothermal Therapy ◽  
Tumor Targeting

12P-Conjugated PEG-Modified Gold Nanorods Combined with Near-Infrared Laser for Tumor Targeting and Photothermal Therapy

2012 ◽  
Vol 12 (9) ◽  
pp. 7198-7205 ◽  
Author(s):  
Tao Zhan ◽  
Pengfei Li ◽  
Shan Bi ◽  
Biao Dong ◽  
Hongwei Song ◽  
...  
Keyword(s):  
Gold Nanorods ◽  
Photothermal Therapy ◽  
Tumor Targeting ◽  
Near Infrared ◽  
Infrared Laser

Core–shell gold nanorod@mesoporous-MOF heterostructures for combinational phototherapy

Nanoscale ◽  
2021 ◽  
Vol 13 (1) ◽  
pp. 131-137
Author(s):  
Zehao Zhou ◽  
Jian Zhao ◽  
Zhenghan Di ◽  
Bei Liu ◽  
Zhaohui Li ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Gold Nanorods ◽  
Photothermal Therapy ◽  
Metal Organic Frameworks ◽  
Gold Nanorod ◽  
Core Shell ◽  
Tumor Treatment ◽  
Metal Organic

A core–shell heterostructure consisting of plasmonic gold nanorods and porphyrinic metal–organic frameworks is synthesized as a promising platform to combine photodynamic therapy and photothermal therapy for enhanced tumor treatment.

scholarly journals Development of theranostic dual-layered Au-liposome for effective tumor targeting and photothermal therapy

2021 ◽  
Vol 19 (1) ◽  
Author(s):  
Miyeon Jeon ◽  
Gaeun Kim ◽  
Wooseung Lee ◽  
Seungki Baek ◽  
Han Na Jung ◽  
...  
Keyword(s):  
In Vivo Imaging ◽  
Photothermal Therapy ◽  
Tumor Targeting ◽  
Therapeutic Strategy ◽  
Tumor Growth Inhibition ◽  
Positron Emission ◽  
Anti Cancer ◽  
Good Biocompatibility ◽  
Targeting Ability

Abstract Background Photothermal therapy (PTT) is an emerging anti-cancer therapeutic strategy that generates hyperthermia to ablate cancer cells under laser irradiation. Gold (Au) coated liposome (AL) was reported as an effective PTT agent with good biocompatibility and excretory property. However, exposed Au components on liposomes can cause instability in vivo and difficulty in further functionalization. Results Herein, we developed a theranostic dual-layered nanomaterial by adding liposomal layer to AL (LAL), followed by attaching polyethylene glycol (PEG) and radiolabeling. Functionalization with PEG improves the in vivo stability of LAL, and radioisotope labeling enables in vivo imaging of LAL. Functionalized LAL is stable in physiological conditions, and 64Cu labeled LAL (64Cu-LAL) shows a sufficient blood circulation property and an effective tumor targeting ability of 16.4%ID g−1 from in vivo positron emission tomography (PET) imaging. Also, intravenously injected LAL shows higher tumor targeting, temperature elevation in vivo, and better PTT effect in orthotopic breast cancer mouse model compared to AL. The tumor growth inhibition rate of LAL was 3.9-fold higher than AL. Conclusion Based on these high stability, in vivo imaging ability, and tumor targeting efficiency, LAL could be a promising theranostic PTT agent. Graphic Abstract

scholarly journals Biocompatible tumor-targeting nanocomposites based on CuS for tumor imaging and photothermal therapy

RSC Advances ◽  
2018 ◽  
Vol 8 (11) ◽  
pp. 6013-6026 ◽  
Author(s):  
Li Liang ◽  
Shuwen Peng ◽  
Zhenwei Yuan ◽  
Chen Wei ◽  
Yuanyuan He ◽  
...  
Keyword(s):  
Photothermal Therapy ◽  
Tumor Targeting ◽  
Tumor Imaging ◽  
Diagnosis And Treatment ◽  
Tumor Treatment ◽  
Active Target

This study provides a good platform for diagnosis and treatment, and it is expected to prompt further exploration of the active target efficiency to achieve better tumor treatment.

Integrin-targeted pH-responsive micelles for enhanced efficiency of anticancer treatment in vitro and in vivo

Nanoscale ◽  
2015 ◽  
Vol 7 (10) ◽  
pp. 4451-4460 ◽  
Author(s):  
Jinjian Liu ◽  
Hongzhang Deng ◽  
Qiang Liu ◽  
Liping Chu ◽  
Yumin Zhang ◽  
...  
Keyword(s):  
Drug Release ◽  
Tumor Targeting ◽  
Drug Loading ◽  
Ph Responsive ◽  
Tumor Treatment ◽  
Anticancer Treatment ◽  
Drug Loading Efficiency ◽  
Targeting Ability

Integrin-targeted pH-responsive micelles were synthesized with an enhanced drug-loading efficiency, tumor-targeting ability and pH-controlled intracellular drug release for enhanced tumor treatment.

scholarly journals AIE nanoparticles camouflaged with tumor cell-derived exosomes for NIR-II imaging-guided photothermal therapy

2021 ◽  
Author(s):  
Yirun Li ◽  
Xiaoxiao Fan ◽  
Yuanyuan Li ◽  
Runze Chen ◽  
Huwei Ni ◽  
...  
Keyword(s):  
Tumor Cell ◽  
Photothermal Therapy ◽  
Tumor Targeting ◽  
Near Infrared ◽  
Specific Targeting ◽  
Specific Tumor ◽  
Targeting Ability ◽  
Targeting Strategy

Nanoparticles (NPs) assisted photothermal therapy (PTT) is a promising cancer treatment modality and has attracted the attention of the scientific mainstream. However, developing NPs that exhibit efficient optical properties and specific tumor targeting capability simultaneously is difficult. Herein, we develop hybrid nanovesicles consisting of tumor cell-derived exosomes (EXO) and organic aggregation-induced emission (AIE) nanoparticles (TT3-oCB NP@EXOs) with enhanced second near-infrared (NIR-II, 900-1700 nm) fluorescence property and PTT functionality. Compared with TT3-oCB NPs, TT3-oCB NP@EXOs exhibit excellent biocompatibility, specific targeting ability in vitro, homing to homologous tumors in vivo, and prolonged circulation time. Furthermore, TT3-oCB NP@EXOs were utilized as biomimetic NPs for NIR-II fluorescence imaging-guided PTT of tumors, due to their high and stable photothermal conversion capacity under 808 nm irradiation. Therefore, the tumor cell-derived EXO/AIE NP hybrid nanovesicles may provide an alternative artificial targeting strategy for improving tumor diagnosis and PTT.

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