Repair of peripheral nerve defects by nerve grafts incorporated with extracellular vesicles from skin-derived precursor Schwann cells

2021 ◽  
Author(s):  
Miaomei Yu ◽  
Guohao Gu ◽  
Meng Cong ◽  
Mingzhi Du ◽  
Wei Wang ◽  
...  
Keyword(s):  
Peripheral Nerve ◽  
Schwann Cells ◽  
Extracellular Vesicles ◽  
Nerve Grafts

TRANSPLANTATION OF PRECONDITIONED SCHWANN CELLS IN PERIPHERAL NERVE GRAFTS AFTER CONTUSION IN THE ADULT SPINAL CORD

2006 ◽  
Vol 88 (11) ◽  
pp. 2400-2410
Author(s):  
ALEXANDRE RASOULI ◽  
NITIN BHATIA ◽  
SOURABH SURYADEVARA ◽  
KIM CAHILL ◽  
RANJAN GUPTA
Keyword(s):  
Spinal Cord ◽  
Peripheral Nerve ◽  
Schwann Cells ◽  
Nerve Grafts ◽  
Peripheral Nerve Grafts ◽  
Adult Spinal Cord

scholarly journals Immunohistochemical, Ultrastructural and Functional Analysis of Axonal Regeneration through Peripheral Nerve Grafts Containing Schwann Cells Expressing BDNF, CNTF or NT3

PLoS ONE ◽  
2013 ◽  
Vol 8 (8) ◽  
pp. e69987 ◽  
Author(s):  
Maria João Godinho ◽  
Lip Teh ◽  
Margaret A. Pollett ◽  
Douglas Goodman ◽  
Stuart I. Hodgetts ◽  
...  
Keyword(s):  
Functional Analysis ◽  
Peripheral Nerve ◽  
Schwann Cells ◽  
Axonal Regeneration ◽  
Nerve Grafts ◽  
Peripheral Nerve Grafts

Transplantation of Preconditioned Schwann Cells in Peripheral Nerve Grafts After Contusion in the Adult Spinal Cord

2006 ◽  
Vol 88 (11) ◽  
pp. 2400-2410 ◽  
Author(s):  
Alexandre Rasouli ◽  
Nitin Bhatia ◽  
Sourabh Suryadevara ◽  
Kim Cahill ◽  
Ranjan Gupta
Keyword(s):  
Spinal Cord ◽  
Peripheral Nerve ◽  
Schwann Cells ◽  
Nerve Grafts ◽  
Peripheral Nerve Grafts ◽  
Adult Spinal Cord

Evaluation of acellular and cellular nerve grafts in repair of rat peripheral nerve

1988 ◽  
Vol 68 (1) ◽  
pp. 117-123 ◽  
Author(s):  
Adarsh K. Gulati
Keyword(s):  
Peripheral Nerve ◽  
Schwann Cells ◽  
Basal Lamina ◽  
Axonal Regeneration ◽  
Content Type ◽  
Limited Ability ◽  
Nerve Grafts ◽  
Rat Peripheral Nerve ◽  
Fine Print

✓ Nerve grafts composed of basal lamina scaffolds and lacking viable Schwann cells have recently been shown to be effective in supporting axonal regeneration. As only short grafts were used in those studies, the present investigation was conducted to evaluate the ability of long acellular basal lamina nerve grafts and equivalent cellular grafts to support axonal regeneration for nerve gap repair. Cellular grafts consisted of nerve segments that had degenerated in situ for 4 weeks. Acellular grafting material consisted of similar segments that were repeatedly frozen and thawed to kill all cells prior to grafting. The results show that host axons can regenerate through the entire 4-cm length of cellular grafts but not through acellular basal lamina grafts. However, in the acellular grafts numerous axons were seen in the proximal 2-cm region. It is concluded that basal lamina grafts possess limited ability to support axonal regeneration. As in cellular grafts, viable Schwann cells appear to be important for regeneration to occur over longer distances.

Nerve-Muscle Sandwich Grafts: the Importance of Schwann Cells in Peripheral Nerve Regeneration through Muscle Basal Lamina Conduits

1995 ◽  
Vol 20 (4) ◽  
pp. 423-428 ◽  
Author(s):  
J. S. CALDER ◽  
C. J. GREEN
Keyword(s):  
Peripheral Nerve ◽  
Nerve Regeneration ◽  
Schwann Cells ◽  
Peripheral Nerve Regeneration ◽  
Perfect Match ◽  
Distal Stump ◽  
Nerve Reconstruction ◽  
Nerve Grafts ◽  
Intermediate Segment ◽  
Nerve Muscle

An interposed segment of nerve was used to enhance the distance over which freeze-thawed muscle autografts will support effective peripheral nerve regeneration. Gaps were created in the sciatic nerves of adult Lewis rats. Regeneration through 1 and 1.5 cm freeze-thawed muscle grafts was compared to regeneration through nerve-muscle sandwich grafts in which muscle grafts of equivalent length were divided and a 2 mm segment of the distal nerve sutured between the two halves of the muscle, providing an intermediate depot of Schwann cells. Electrophysiological and morphological evaluation was carried out 40 weeks after operation. Despite lengthening the graft, and having four anastomoses instead of two, this manoeuvre enhanced nerve regeneration over each gap studied and for the 1.5 cm gaps compared favourably with perfect match nerve autografts. In addition, a number of grafts were examined at 7 and 14 days by Sl00 immunohistochemistry. Schwann cell migration was seen to proceed both proximally and distally from the intermediate segment at a rate similar to that from the distal stump. It is concluded that sandwich grafts may prove to be effective alternatives to cutaneous nerve grafts for peripheral nerve reconstruction.

Molecular basis of interactions between regenerating adult rat thalamic axons and Schwann cells in peripheral nerve grafts II. Tenascin-C

1995 ◽  
Vol 361 (2) ◽  
pp. 210-224 ◽  
Author(s):  
Y. Zhang ◽  
G. Campbell ◽  
P. N. Anderson ◽  
R. Martini ◽  
M. Schachner ◽  
...  
Keyword(s):  
Peripheral Nerve ◽  
Schwann Cells ◽  
Molecular Basis ◽  
Tenascin C ◽  
Adult Rat ◽  
Nerve Grafts ◽  
Peripheral Nerve Grafts
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