This chapter describes the six most widely used generic preference-based measures of health (GPBMs) (also known as multiattribute utility scales): EQ-5D, SF-6D, HUI, AQoL, 15D, and QWB. GPBMs have become the most widely used method for obtaining health state utility values. They contain a health state classification with multilevel dimensions that together describe a universe of health states and a set of values (where full health = 1 and dead = 0) for each health state obtained by eliciting the preferences (typically) of members of the general population. These measures are reviewed in terms of their content, methods of valuation, the scores they generate, and the possible reasons for the differences found. Their performance is reviewed using published evidence on their validity across conditions, and the implications for their use in policy making discussed. The chapter also reviews the generic measures available for use in populations of children and adolescents.