Current role of sodium bicarbonate–based preprocedural hydration for the prevention of contrast-induced acute kidney injury: A meta-analysis

New biomarkers for acute kidney injury (AKI) have improved our understanding of the etiology and pathogenesis of AKI. Depending on their origin, function, and kinetic profile, biomarkers have a role in screening, diagnosis, prognostication, and monitoring of AKI. This offers opportunities to improve the management of AKI, but concerns and limitations remain. In this review, we summarize the current role of new AKI biomarkers in the management of AKI and outline some of the ongoing limitations and challenges.

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Hydration Strategies for Preventing Contrast-Induced Acute Kidney Injury: A Systematic Review and Bayesian Network Meta-Analysis

Journal of Interventional Cardiology ◽

10.1155/2020/7292675 ◽

2020 ◽

Vol 2020 ◽

pp. 1-16

Author(s):

Qiuping Cai ◽

Ran Jing ◽

Wanfen Zhang ◽

Yushang Tang ◽

Xiaoping Li ◽

...

Keyword(s):

Acute Kidney Injury ◽

Sodium Chloride ◽

Sodium Bicarbonate ◽

Optimal Strategy ◽

Meta Analysis ◽

Kidney Injury ◽

Cochrane Library ◽

Oral Hydration ◽

Ovid Medline ◽

Risk Patients

Aims. Many previous studies have examined the effect of different hydration strategies on prevention of contrast-induced acute kidney injury (CI-AKI), but the optimal strategy is unknown. We performed a network meta-analysis (NWM) of these previous studies to identify the optimal strategy. Methods and Results. Web of Science, PubMed, OVID Medline, and Cochrane Library were searched from their inception dates to September 30, 2018. Randomized controlled trials (RCTs) were selected based on strict inclusion criteria, and a Bayesian NWM was performed using WinBUGS V.1.4.3. We finally analyzed 60 eligible RCTs, which examined 21,293 patients and 2232 CI-AKI events. Compared to intravenous 0.9% sodium chloride (reference), intravenous sodium bicarbonate (OR [95% CI]: 0.74 [0.57, 0.93]), hemodynamic guided hydration (0.41 [0.18, 0.93]), and RenalGuard guided hydration (0.32 [0.14, 0.70]) significantly reduced the occurrence of CI-AKI. Oral hydration and intravenous 0.9% sodium chloride were each noninferior to no hydration in preventing CI-AKI. Intravenous 0.9% sodium chloride, sodium bicarbonate, and hemodynamic guided hydration were each noninferior to oral hydration in preventing CI-AKI. Based on surface under the cumulative ranking curve values, the RenalGuard system was best (0.974) and hemodynamic guided hydration was second best (0.849). Conclusion. There was substantial evidence to support the use of RenalGuard or hemodynamic guided hydration for preventing CI-AKI in high-risk patients, especially those with chronic kidney disease or cardiac dysfunction.

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Role of statins in preventing cardiac surgery-associated acute kidney injury: an updated meta-analysis of randomized controlled trials

Therapeutics and Clinical Risk Management ◽

10.2147/tcrm.s160298 ◽

2018 ◽

Vol Volume 14 ◽

pp. 475-482 ◽

Cited By ~ 10

Author(s):

Song-jian He ◽

Qiang Liu ◽

Hua-qiu Li ◽

Fang Tian ◽

Shi-yu Chen ◽

...

Keyword(s):

Acute Kidney Injury ◽

Cardiac Surgery ◽

Randomized Controlled Trials ◽

Meta Analysis ◽

Kidney Injury ◽

Controlled Trials ◽

Randomized Controlled

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THE ROLE OF ASCORBIC ACID IN REDUCING THE INCIDENCE OF STAGE 3 ACUTE KIDNEY INJURY IN PATIENTS WITH SEPTIC SHOCK: A SYSTEMATIC REVIEW AND META-ANALYSIS

CHEST Journal ◽

10.1016/j.chest.2021.07.979 ◽

2021 ◽

Vol 160 (4) ◽

pp. A1057

Author(s):

Waleed Khokher ◽

Nithin Kesireddy ◽

prabath herath mudiyanselage ◽

Saffa Iftikhar ◽

Azizullah Beran Beran ◽

...

Keyword(s):

Systematic Review ◽

Septic Shock ◽

Acute Kidney Injury ◽

Ascorbic Acid ◽

Meta Analysis ◽

Kidney Injury

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MicroRNA in Human Acute Kidney Injury: A Systematic Review Protocol

Canadian Journal of Kidney Health and Disease ◽

10.1177/20543581211009999 ◽

2021 ◽

Vol 8 ◽

pp. 205435812110099

Author(s):

Adrianna Douvris ◽

Dylan Burger ◽

Rosendo A. Rodriguez ◽

Edward G. Clark ◽

Jose Viñas ◽

...

Keyword(s):

Systematic Review ◽

Acute Kidney Injury ◽

Animal Models ◽

Human Subjects ◽

Meta Analysis ◽

Kidney Injury ◽

Diagnostic Tools ◽

High Morbidity ◽

Statistical Heterogeneity

Background: Acute kidney injury (AKI) is a common complication of hospitalization with high morbidity and mortality for which no effective treatments exist and for which current diagnostic tools have limitations for earlier identification. MicroRNAs (miRNAs) are small non-coding RNAs that have been implicated in the pathogenesis of AKI, and some miRNAs have shown promise as therapeutic tools in animal models of AKI. However, less is known about the role of miRNAs in human AKI. Objective: To evaluate the role of miRNAs in human subjects with AKI. Design: Systematic review and meta-analysis Measurements: Quantification of miRNA levels from human blood, urine, or kidney biopsy samples, and measures of renal function as defined in the study protocol. Methods: A comprehensive search strategy for Ovid MEDLINE All, Embase, Web of Science, and CENTRAL will be developed to identify investigational studies that evaluated the relationship between miRNA levels and human AKI. Primary outcomes will include measurements of kidney function and miRNA levels. Study screening, review and data extraction will be performed independently by 2 reviewers. Study quality and certainty of evidence will be assessed with validated tools. A narrative synthesis will be included and the possibility for meta-analysis will be assessed according to characteristics of clinical and statistical heterogeneity between studies. Limitations: These include (1) lack of randomized trials of miRNAs for the prevention or treatment of human AKI, (2) quality of included studies, and (3) sources of clinical and statistical heterogeneity that may affect strength and reproducibility of results. Conclusion: Previous studies of miRNAs in different animal models of AKI have generated strong interest on their use for the prevention and treatment of human AKI. This systematic review will characterize the most promising miRNAs for human research and will identify methodological constraints from miRNA research in human AKI to help inform the design of future studies. Systematic review registration: PROSPERO CRD42020201253

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