Early pregnancy lipid concentrations and spontaneous preterm birth

Abstract Background: Preterm birth (occurring before 37 completed weeks of gestation) affects 15 million infants annually, 7.5% of which die due to related complications. The detection and early diagnosis are therefore paramount in order to prevent the development of prematurity and its consequences. So far, focus has been laid on the association between reduced intrauterine fetal growth during late gestation and prematurity. The aim of the current study was to investigate the association between accelerated fetal growth in early pregnancy and the risk of preterm birth. Methods: This prospective cohort study included 69 617 singleton pregnancies without congenital malformations and with available biometric measurements during the first and second trimester. Estimation of fetal growth was based on measurements of biparietal diameter (BPD) at first and second trimester scan. We investigated the association between accelerated fetal growth and preterm birth prior to 37 weeks of gestation. The outcome was further stratified into very preterm birth (before 32 weeks of gestation) or moderate preterm birth (between 32 and 37 weeks of gestation) and medically induced or spontaneous preterm birth and was further explored. Results: The odds of prematurity were increased among fetuses with accelerated BPD growth (> 90th centile) estimated between first and second ultrasound scan, even after adjustment for possible confounders (aOR 1.36; 95% CI 1.20-1.54). The findings remained significant what regards moderate preterm births but not earlier births. Regarding medically induced preterm birth, the odds were found to be elevated in the group of fetuses with accelerated growth in early pregnancy (aOR 1.34; 95% CI 1.11-1.63). On the contrary, fetuses with delayed fetal growth exhibited lower risk for both overall and spontaneous preterm birth.Conclusions: Fetuses with accelerated BPD growth in early pregnancy, detected by ultrasound examination during the second trimester, exhibited increased risk of being born preterm. The findings of the current study suggest that fetal growth in early pregnancy should be taken into account when assessing the likelihood for preterm birth.

Download Full-text

Transcriptome analysis of early pregnancy vitamin D status and spontaneous preterm birth

PLoS ONE ◽

10.1371/journal.pone.0227193 ◽

2020 ◽

Vol 15 (1) ◽

pp. e0227193 ◽

Cited By ~ 2

Author(s):

Aishwarya P. Yadama ◽

Hooman Mirzakhani ◽

Thomas F. McElrath ◽

Augusto A. Litonjua ◽

Scott T. Weiss

Keyword(s):

Vitamin D ◽

Preterm Birth ◽

Early Pregnancy ◽

Transcriptome Analysis ◽

Vitamin D Status ◽

Spontaneous Preterm Birth

Download Full-text

Circulating Angiogenic Factors in Early Pregnancy and the Risk of Preeclampsia, Intrauterine Growth Restriction, Spontaneous Preterm Birth, and Stillbirth

Yearbook of Neonatal and Perinatal Medicine ◽

10.1016/s8756-5005(08)79006-1 ◽

2008 ◽

Vol 2008 ◽

pp. 21-22

Author(s):

R.J. Wong

Keyword(s):

Preterm Birth ◽

Early Pregnancy ◽

Intrauterine Growth Restriction ◽

Angiogenic Factors ◽

Growth Restriction ◽

Spontaneous Preterm Birth ◽

Intrauterine Growth ◽

Risk Of Preeclampsia

Download Full-text

Accelerated fetal growth in early pregnancy and risk of preterm birth: a prospective cohort study

10.21203/rs.3.rs-39242/v5 ◽

2020 ◽

Author(s):

Evangelia Elenis ◽

Anna-Karin Wikström ◽

Marija Simic

Keyword(s):

Cohort Study ◽

Preterm Birth ◽

Prospective Cohort Study ◽

Fetal Growth ◽

Early Pregnancy ◽

Prospective Cohort ◽

Preterm Births ◽

Second Trimester ◽

Spontaneous Preterm Birth ◽

Very Preterm

Abstract Background: Preterm birth (occurring before 37 completed weeks of gestation) affects 15 million infants annually, 7.5% of which die due to related complications. The detection and early diagnosis are therefore paramount in order to prevent the development of prematurity and its consequences. So far, focus has been laid on the association between reduced intrauterine fetal growth during late gestation and prematurity. The aim of the current study was to investigate the association between accelerated fetal growth in early pregnancy and the risk of preterm birth. Methods: This prospective cohort study included 69 617 singleton pregnancies without congenital malformations and with available biometric measurements during the first and second trimester. Estimation of fetal growth was based on measurements of biparietal diameter (BPD) at first and second trimester scan. We investigated the association between accelerated fetal growth and preterm birth prior to 37 weeks of gestation. The outcome was further stratified into very preterm birth (before 32 weeks of gestation) or moderate preterm birth (between 32 and 37 weeks of gestation) and medically induced or spontaneous preterm birth and was further explored. Results: The odds of prematurity were increased among fetuses with accelerated BPD growth (> 90th centile) estimated between first and second ultrasound scan, even after adjustment for possible confounders (aOR 1.36; 95% CI 1.20-1.54). The findings remained significant what regards moderate preterm births but not very preterm births. Regarding medically induced preterm birth, the odds were found to be elevated in the group of fetuses with accelerated growth in early pregnancy (aOR 1.34; 95% CI 1.11-1.63). On the contrary, fetuses with delayed fetal growth exhibited lower odds for both overall and spontaneous preterm birth.Conclusions: Fetuses with accelerated BPD growth in early pregnancy, detected by ultrasound examination during the second trimester, exhibited increased odds of being born preterm. The findings of the current study suggest that fetal growth in early pregnancy should be taken into account when assessing the risk for preterm birth.

Download Full-text

Early pregnancy serum neopterin concentrations predict spontaneous preterm birth in asymptomatic pregnant women

Journal of Perinatal Medicine ◽

10.1515/jpm-2015-0081 ◽

2016 ◽

Vol 44 (5) ◽

Cited By ~ 3

Author(s):

Dan Bogdan Navolan ◽

Simona Vladareanu ◽

Imad Lahdou ◽

Ioana Ciohat ◽

Christian Kleist ◽

...

Keyword(s):

Preterm Birth ◽

Pregnant Women ◽

Early Pregnancy ◽

Gestational Age ◽

Odds Ratio ◽

Considerable Increase ◽

Second Trimester ◽

Spontaneous Preterm Birth ◽

Serum Neopterin

AbstractTo investigate if early pregnancy serum neopterin concentrations (EPSN) could predict spontaneous preterm birth (SPB).EPSN was measured in 92 sera collected from 46 pregnant women with birth at term and 40 sera from 20 pregnant women with preterm birth. Two sera were collected for each case: in the first and early second trimester.EPSN concentrations correlate with gestational age (ρ=0.275, P=0.001), a correlation which was present in both groups: term and preterm birth. EPSN were higher in pregnancies with SPB compared with normal pregnancies (6.27±1.03 vs. 6.04±0.15, P=0.039). Patients with SPB showed a considerable increase of EPSN in the second trimester compared with patients with birth at term (7.30±1.53 vs. 6.16±0.23, P=0.043). A sharper increase was found in the group with SPB before 32 weeks of pregnancy (wp) (9.83±4.36 vs. 6.16±0.23, P=0.016). Pregnant women with an early second trimester serum neopterin value of above 8 nmol/L are associated with a risk of SPB before 32 wp (odds ratio=14.4, P=0.01) and of SPB before 34 wp (odds ratio=3.6, P=0.05), respectively.EPSN increases with the gestational age and predicts SPB in asymptomatic pregnant women.

Download Full-text