Comparison of early pregnancy serum concentration of neopterin, neopterin/creatinine ratio, C‑reactive protein, and chitotriosidase, in pregnant women with birth at term and spontaneous preterm birth

AbstractTo investigate if early pregnancy serum neopterin concentrations (EPSN) could predict spontaneous preterm birth (SPB).EPSN was measured in 92 sera collected from 46 pregnant women with birth at term and 40 sera from 20 pregnant women with preterm birth. Two sera were collected for each case: in the first and early second trimester.EPSN concentrations correlate with gestational age (ρ=0.275, P=0.001), a correlation which was present in both groups: term and preterm birth. EPSN were higher in pregnancies with SPB compared with normal pregnancies (6.27±1.03 vs. 6.04±0.15, P=0.039). Patients with SPB showed a considerable increase of EPSN in the second trimester compared with patients with birth at term (7.30±1.53 vs. 6.16±0.23, P=0.043). A sharper increase was found in the group with SPB before 32 weeks of pregnancy (wp) (9.83±4.36 vs. 6.16±0.23, P=0.016). Pregnant women with an early second trimester serum neopterin value of above 8 nmol/L are associated with a risk of SPB before 32 wp (odds ratio=14.4, P=0.01) and of SPB before 34 wp (odds ratio=3.6, P=0.05), respectively.EPSN increases with the gestational age and predicts SPB in asymptomatic pregnant women.

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Maternal serum C-reactive protein in early pregnancy and occurrence of preterm premature rupture of membranes and preterm birth

Journal of Obstetrics and Gynaecology Research ◽

10.1111/j.1447-0756.2011.01804.x ◽

2012 ◽

Vol 38 (5) ◽

pp. 780-786 ◽

Cited By ~ 18

Author(s):

Lida Moghaddam Banaem ◽

Bita Mohamadi ◽

Mohamad Asghari Jaafarabadi ◽

Narges Aliyan Moghadam

Keyword(s):

Preterm Birth ◽

Early Pregnancy ◽

Maternal Serum ◽

C Reactive Protein ◽

Premature Rupture Of Membranes ◽

Premature Rupture ◽

Reactive Protein ◽

Preterm Premature Rupture

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C-reactive protein levels and oxidative stress markers as predictors of spontaneous preterm birth in women from South Bulgaria

10.21175/rad.abstr.book.2021.6.7 ◽

2021 ◽

Author(s):

Iliana Koleva ◽

Yanka Karamalakova ◽

Maria Angelova ◽

Galina Nikolova

Keyword(s):

Oxidative Stress ◽

Preterm Birth ◽

Oxidative Stress Markers ◽

C Reactive Protein ◽

Spontaneous Preterm Birth ◽

Protein Levels ◽

Reactive Protein ◽

Stress Markers ◽

And Oxidative Stress

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DOES ELEVATED 72-HOUR PEAK POST OPERATIVE C-REACTIVE PROTEIN SERUM CONCENTRATION PREDICT POSTOPERATIVE COMPLICATIONS IN MAJOR HEAD AND NECK CANCER OPERATIONS?

10.26226/morressier.578e3b4dd462b80292381e1b ◽

2016 ◽

Author(s):

Sarah Touyz

Keyword(s):

Head And Neck Cancer ◽

Postoperative Complications ◽

Serum Concentration ◽

Head And Neck ◽

Neck Cancer ◽

C Reactive Protein ◽

Reactive Protein ◽

Protein Serum

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Serum Uric Acid Level as a Predictive Biomarker of Gestational Hypertension Severity; A Prospective Observational Case-Control Study

Reviews on Recent Clinical Trials ◽

10.2174/1574887115666200709142119 ◽

2020 ◽

Vol 15 (3) ◽

pp. 227-239 ◽

Cited By ~ 1

Author(s):

Hader I. Sakr ◽

Akef A. Khowailed ◽

Reham S. Al-Fakharany ◽

Dina S. Abdel-Fattah ◽

Ahmed A. Taha

Keyword(s):

Blood Pressure ◽

Pregnant Women ◽

Case Control Study ◽

Serum Urate ◽

Interleukin 1Β ◽

Pregnancy Induced Hypertension ◽

C Reactive Protein ◽

Reactive Protein ◽

Induced Hypertension ◽

Control Study

Background: Pre-eclampsia poses a significant potential risk of hypertensive disorders during pregnancy, a leading cause of maternal deaths. Hyperuricemia is associated with adverse effects on endothelial function, normal cellular metabolism, and platelet aggregation and adhesion. This study was designed to compare serum urate levels in normotensive pregnant women to those with pregnancy-induced hypertension, and to evaluate its value as a potential predictive marker of hypertension severity during pregnancy. Methods: A prospective, observational, case-control study conducted on 100 pregnant women in their third trimester. Pregnant women were classified into two groups (n=50) according to arterial blood pressure measurements: group I had normal blood pressure, and group II had a blood pressure of ≥ 140/90, which was further subdivided according to hypertension severity into IIa (pregnancy- induced hypertension, IIb (mild pre-eclampsia), and IIc (severe pre-eclampsia). Blood samples were obtained on admission. Serum urate, high sensitive C-reactive protein, and interleukin-1β levels, and lipid profile were compared among the groups. Results: A significant increase in the mean values of serum urate, C-reactive protein, and interleukin- 1β levels was detected in gestational hypertensives. In addition, there was a positive correlation between serum urate levels and C-reactive protein and interleukin-1β, as well as between serum urate levels and hypertension severity. Conclusion: Hyperuricemia and increased C-reactive protein and interleukin-1β serum levels correlate with the severity of pregnancy-induced hypertension, and these biomarkers may play a role in the pathogenesis of pre-eclampsia. Serum urate measurement is sensitive, reliable markers that correlate well with the severity of hypertension in pregnant females with pre-eclampsia.

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