70: Altered fetal brain programming in a preeclampsia-like mouse model and its prevention by prenatal treatment with pravastatin

2013 ◽  
Vol 208 (1) ◽  
pp. S41 ◽  
Author(s):  
Alissa Carver ◽  
Maged Costantine ◽  
Esther Tamayo ◽  
Huaizhi Yin ◽  
J. Regino Perez-Polo ◽  
...  
Keyword(s):  
Mouse Model ◽  
Fetal Brain ◽  
Prenatal Treatment

scholarly journals Fetal brain sparing in a mouse model of chronic maternal hypoxia

2017 ◽  
Vol 39 (6) ◽  
pp. 1172-1184 ◽  
Author(s):  
Lindsay S Cahill ◽  
Johnathan Hoggarth ◽  
Jason P Lerch ◽  
Mike Seed ◽  
Christopher K Macgowan ◽  
...  
Keyword(s):  
Blood Flow ◽  
Mouse Model ◽  
Chronic Hypoxia ◽  
Fetal Brain ◽  
Adult Brain ◽  
Brain Morphology ◽  
Ductus Venosus ◽  
Experimental Mouse Model ◽  
Experimental Mouse ◽  
Maternal Hypoxia

Hypoxic stress is a common occurrence during human pregnancy, yet little is known about its effects on the fetal brain. This study examined the fetal hemodynamic responses to chronic hypoxia in an experimental mouse model of chronic maternal hypoxia (11% O2 from E14.5 to E17.5). Using high-frequency Doppler ultrasound, we found fetal cerebral and ductus venosus blood flow were both elevated by 69% and pulmonary blood flow was decreased by 62% in the fetuses exposed to chronic hypoxia compared to controls. This demonstrates that brain sparing persists during chronic fetal hypoxia and is mediated by “streaming,” where highly oxygenated blood preferentially flows through the ductus venosus towards the cerebral circulation, bypassing the liver and the lungs. Consistent with these changes in blood flow, the fetal brain volume measured by MRI is preserved, while the liver and lung volumes decreased compared to controls. However, hypoxia exposed fetuses were rendered vulnerable to an acute hypoxic challenge (8% O2 for 3 min), demonstrating global blood flow decreases consistent with imminent fetal demise rather than elevated cerebral blood flow. Despite this vulnerability, there were no differences in adult brain morphology in the mice exposed to chronic maternal hypoxia compared to controls.

scholarly journals Prenatal Treatment of Mosaic Mice (Atp7a mo-ms) Mouse Model for Menkes Disease, with Copper Combined by Dimethyldithiocarbamate (DMDTC)

PLoS ONE ◽  
2012 ◽  
Vol 7 (7) ◽  
pp. e40400 ◽  
Author(s):  
Małgorzata Lenartowicz ◽  
Wojciech Krzeptowski ◽  
Paweł Koteja ◽  
Katarzyna Chrząścik ◽  
Lisbeth Birk Møller
Keyword(s):  
Mouse Model ◽  
Menkes Disease ◽  
Prenatal Treatment

scholarly journals The fetal brain transcriptome and neonatal behavioral phenotype in the Ts1Cje mouse model of Down syndrome

2015 ◽  
Vol 167 (9) ◽  
pp. 1993-2008 ◽  
Author(s):  
Faycal Guedj ◽  
Jeroen L. A. Pennings ◽  
Millie A. Ferres ◽  
Leah C. Graham ◽  
Heather C. Wick ◽  
...  
Keyword(s):  
Down Syndrome ◽  
Mouse Model ◽  
Fetal Brain ◽  
Behavioral Phenotype ◽  
Brain Transcriptome

scholarly journals Apigenin as a Candidate Prenatal Treatment for Trisomy 21: Effects in Human Amniocytes and the Ts1Cje Mouse Model

2020 ◽  
Vol 107 (5) ◽  
pp. 911-931
Author(s):  
Faycal Guedj ◽  
Ashley E. Siegel ◽  
Jeroen L.A. Pennings ◽  
Fatimah Alsebaa ◽  
Lauren J. Massingham ◽  
...  
Keyword(s):  
Mouse Model ◽  
Trisomy 21 ◽  
Prenatal Treatment

703: Prenatal treatment with neuroprotective peptides restores DYRK1A expression in a mouse model of Down syndrome

2009 ◽  
Vol 201 (6) ◽  
pp. S255
Author(s):  
Maddalena Incerti ◽  
Robin Roberson ◽  
Christopher Nold ◽  
Laura Toso ◽  
Joy Vink ◽  
...  
Keyword(s):  
Down Syndrome ◽  
Mouse Model ◽  
Prenatal Treatment

Administration of melatonin for prevention of preterm birth and fetal brain injury associated with premature birth in a mouse model

2019 ◽  
Vol 82 (3) ◽  
Author(s):  
Ji Yeon Lee ◽  
Haengseok Song ◽  
Oyunbileg Dash ◽  
Mira Park ◽  
Na E. Shin ◽  
...  
Keyword(s):  
Preterm Birth ◽  
Brain Injury ◽  
Mouse Model ◽  
Premature Birth ◽  
Fetal Brain
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