254: Incidence of preterm birth with primary infertility, normal uterine cavity and subsequent singleton gestation conceived spontaneously, via intrauterine insemination, or in vitro fertilization

Abstract Background: In vitro fertilization (IVF) births contribute to a considerable proportion of preterm birth (PTB) each year. However, there is no formal surveillance of adverse perinatal outcomes for less invasive fertility treatments. The study objective was to determine the effect of fertility treatment (in vitro fertilization, intrauterine insemination, usually with ovulation drugs (IUI), or ovulation drugs alone) on preterm birth, compared to no treatment in subfertile women.Methods: The Fertility Experiences Study (FES) is a retrospective cohort study conducted at the University of Utah between April 2010 and September 2012. Women with a history of primary subfertility self-reported treatment data via survey and interviews. Participant data were linked to birth certificates and fetal death records to asses for perinatal outcomes, particularly preterm birth.Results: A total 487 birth certificates and 3 fetal death records were linked as first births for study participants who completed questionnaires. Among linked births, 19% had a PTB. After adjustment for maternal age, paternal age, maternal education, annual income, religious affiliation, female or male fertility diagnosis, and duration of subfertility, the odds ratios and 95% confidence intervals (CI) for PTB were 2.17 (CI: 0.99, 4.75) for births conceived using ovulation drugs, 3.17 (CI: 1.4, 7.19) for neonates conceived using IUI and 4.24 (CI: 2.05, 8.77) for neonates conceived by IVF, compared to women with subfertility who used no treatment during the month of conception. A reported diagnosis of female factor infertility increased the adjusted odds of having a PTB 2.99 (CI: 1.5, 5.97). Duration of pregnancy attempt was not independently associated with PTB. In restricting analyses to singleton gestation, odds ratios remained elevated but were not significant for any type of treatment.Conclusion: IVF, IUI, and ovulation drugs were all associated with a higher incidence of preterm birth and low birth weight, predominantly related to multiple gestation births.

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Conversion of high-response gonadotropin intrauterine insemination cycles to in vitro fertilization results in excellent ongoing pregnancy rates

Fertility and Sterility ◽

10.1016/s0015-0282(01)03244-7 ◽

2002 ◽

Vol 77 (4) ◽

pp. 715-720 ◽

Cited By ~ 11

Author(s):

Amy M Antman ◽

Joseph A Politch ◽

Elizabeth S Ginsburg

Keyword(s):

In Vitro Fertilization ◽

Intrauterine Insemination ◽

Pregnancy Rates ◽

High Response ◽

Ongoing Pregnancy ◽

Vitro Fertilization

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Preterm and premature rupture of membranes in pregnancies after in vitro fertilization

Medicinski pregled ◽

10.2298/mpns0508375t ◽

2005 ◽

Vol 58 (7-8) ◽

pp. 375-379 ◽

Cited By ~ 2

Author(s):

Dunja Tabs ◽

Tihomir Vejnovic ◽

Nebojsa Radunovic

Keyword(s):

In Vitro Fertilization ◽

Intrauterine Insemination ◽

Premature Rupture Of Membranes ◽

Premature Rupture ◽

Fertilization Program ◽

Vitro Fertilization ◽

Preterm Premature Rupture ◽

Natural Conception ◽

Singleton Pregnancies

Women conceiving by assisted reproduction are at higher risk for preterm and premature rupture of membranes. The aim of our study was to estimate and compare incidence of preterm premature rupture of membranes in singleton pregnancies of women who conceived by intrauterine insemination and in vitro fertilization, from 1999 to 2003. We investigated 87 women from the intrauterine insemination, and 102 from the in vitro fertilization program. There were no statistically significant differences in regard to preterm and premature rupture of membranes: p>0.75 in two groups. The incidence of premature rupture of membranes was 2.30% (after intrauterine insemination) and 2.94% (after in vitro fertilization). There was no statistically significant differences in regard to preterm and premature rupture of membranes in women who conceived by insemination and in vitro fertilization. Estimated incidence of preterm and premature rupture of membranes was similar to the literature data and also similar to incidence after natural conception.

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Comparative Study Between Mock Embryo Transfer Prior To The Treatment Cycle and Real Embryo Transfer In In Vitro Fertilization

KnE Medicine ◽

10.18502/kme.v1i1.538 ◽

2016 ◽

Vol 1 (1) ◽

Author(s):

Hilma Putri Lubis

Keyword(s):

In Vitro Fertilization ◽

Embryo Transfer ◽

Treatment Cycle ◽

Uterine Cavity ◽

Pregnancy Rates ◽

Clinical Pregnancy ◽

Vitro Fertilization ◽

Significant Difference ◽

Clinical Pregnancy Rates

IntroductionA trial or mock embryo transfer (ET) may influence pregnancy rates and it performed prior to ET allows the clinician to assess the uterine cavity and the utero-cervical angle. The aim of this study is to compare the consistency of the type of ET in mock ET with real ET.Material & MethodsA retrospective comparative analysis of patients who underwent in vitro fertilization or ICSI cycle from January 2014 to December 2014 in Halim Fertility Center was done. The type of transfer was divided into two groups: ‘easy’ or ‘difficult’. An easy ET was defined as a transfer that occurred without the use of manipulation or other instrumentation and difficult ET was considered when additional instrumentation was required.ResultsFrom the study, 103 patients who underwent Mock-ET, we found 58 patients (56.3%) with easy ET and 45 patients (43.7%) with difficult ET, which with hard catheter ET in 17 patients (16.5%), with osfander assistance in 20 patients (19.4%) and with stylet in 8 patients (7,8%). 58 patients with Easy Mock ET group were entirely easy real ET (100%) and 45 patients with difficult Mock ET group also entirely were difficult real ET (100%). The Statistical analysis shows no significant difference between the mock ET and real ET groups (p>0,05). In easy real ET, clinical pregnancy rates were 32.8% and in difficult real ET, clinical pregnancy rates were 26.7% with no significant difference between the groups (p>0,05).Conclusion:Mock ET prior to the treatment cycle is consistent with real ET.

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