Copper intrauterine device and incident sexually transmitted infections

ObjectivesReproductive aged women are at risk of pregnancy and sexually transmitted infections (STI). Understanding drivers of STI acquisition, including any association with widely used contraceptives, could help us to reduce STI prevalence and comorbidities. We compared the risk of STI among women randomised to three contraceptive methods.MethodsWe conducted a secondary analysis to assess the risk of chlamydia and gonorrhoea in a clinical trial evaluating HIV risk among 7829 women aged 16–35 randomised to intramuscular depot medroxyprogesterone acetate (DMPA-IM), a copper intrauterine device (IUD) or a levonorgestrel (LNG) implant. We estimated chlamydia and gonorrhoea prevalences by contraceptive group and prevalence ratios (PR) using log-binomial regression.ResultsAt baseline, chlamydia and gonorrhoea prevalences were 18% and 5%, respectively. Final visit chlamydia prevalence did not differ significantly between DMPA-IM and copper IUD groups or between copper IUD and LNG implant groups. The DMPA-IM group had significantly lower risk of chlamydia compared with the LNG implant group (PR 0.83, 95% CI 0.72 to 0.95). Final visit gonorrhoea prevalence differed significantly only between the DMPA-IM and the copper IUD groups (PR 0.67, 95% CI 0.52 to 0.87).ConclusionsThe findings suggest that chlamydia and gonorrhoea risk may vary with contraceptive method use. Further investigation is warranted to better understand the mechanisms of chlamydia and gonorrhoea susceptibility in the context of contraceptive use.

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Intrauterine device use in an urban university clinic: safety of use in a population at high risk for sexually transmitted infections

Contraception ◽

10.1016/j.contraception.2015.06.008 ◽

2015 ◽

Vol 92 (4) ◽

pp. 319-322 ◽

Cited By ~ 3

Author(s):

Robin W. Drake ◽

Summer L. Martins ◽

Amy K. Whitaker

Keyword(s):

High Risk ◽

Sexually Transmitted Infections ◽

Intrauterine Device ◽

Sexually Transmitted ◽

Urban University ◽

Device Use

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Intrauterine Device Use, Sexually Transmitted Infections, and Fertility: A Prospective Cohort Study

Obstetrical & Gynecological Survey ◽

10.1097/01.ogx.0000806124.08178.c8 ◽

2021 ◽

Vol 76 (12) ◽

pp. 746-747

Author(s):

Jeffrey F. Peipert ◽

Qiuhong Zhao ◽

Courtney A. Schreiber ◽

Stephanie Teal ◽

David K. Turok ◽

...

Keyword(s):

Cohort Study ◽

Sexually Transmitted Infections ◽

Prospective Cohort Study ◽

Prospective Cohort ◽

Intrauterine Device ◽

Sexually Transmitted ◽

Device Use

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Bacterial vaginosis: prevalence, risk profile and association with sexually transmitted infections

Revista de Epidemiologia e Controle de Infecção ◽

10.17058/jeic.v10i3.14984 ◽

2020 ◽

Vol 10 (3) ◽

Author(s):

Pedro Moregola Teixeira ◽

Wendel Coura Vital ◽

Angélica Alves Lima ◽

Nayara Nascimento Toledo Silva ◽

Cláudia Martins Carneiro ◽

...

Keyword(s):

Risk Factors ◽

Bacterial Vaginosis ◽

Sexually Transmitted Infections ◽

Trichomonas Vaginalis ◽

Intrauterine Device ◽

Sexually Transmitted ◽

Factors Associated ◽

Gram Staining ◽

Informed Consent Form ◽

Vaginal Swabs

Background and Objectives: Bacterial vaginosis (BV) is the most common cause of vaginal discharge in the world. The study aimed to estimate the prevalence and to identify risk factors associated with bacterial vaginosis. Methods: A cross-sectional study was conducted in Ouro Preto, Brazil, between February and December 2017. Three hundred and forty-one women aged 18 years or older, users of the Brazilian Unified Health System, participated in this study. Women who used oral or topical antibiotics in the four weeks prior to the sample collection and women who had undergone a total hysterectomy were excluded from the study. After signing the Informed Consent Form and filling out a questionnaire containing sociodemographic, behavioral and sexual data, the participants were directed to the collection room, where the nurse collected the samples for the preventive examination of the cervix and also two vaginal swabs. Vaginal swabs and cervical samples were analyzed for cytological abnormalities and BV using Gram staining and cytology. Pathogens causing sexually transmitted infections (STIs) were identified by Polymerase Chain Reaction (PCR). For the analysis of the data, statistical package STATA version 10.0 was used. This study was approved by the Research Ethics Committee of the Federal University of Ouro Preto (UFOP). Results: During the study, 341 women were evaluated. The prevalence of BV using Gram staining (32.5% [CI95% 27.7=37.7%]) and cytology (27.7% [CI95% 23.0=32.8%]) was similar, however, the sensitivity of cytology was lower (77.8%). Risk factors associated with BV were smoking (IRR 1.5[CI95%: 1.1 = 2.1]), use of an intrauterine device (IRR 2.8 [CI95%: 1.2 = 6.5]), and past medical history of BV (IRR 1.5 [CI95%: 1.1 = 2.1]). Correlation between the presence of BV and Trichomonas vaginalis (TV) infection (r=0.24) was observed. Conclusion: The prevalence of BV was affected by life habits and was prevalent in women with TV. Thus, behavioral and social prevention approaches to women with diverse risk profiles may help mitigate TV/BV prevalence and recurrence of BV.

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