Effect of mulmina mango as an adjunct to standard of care treatment on COVID-19 positive subjects undergoing treatment for COVID-19 in hospital quarantine (Dedicated Covid Health Centre)

There are no approved drugs to treat COVID-19, and the vaccine is likely to be ready by early 2021. Many clinical studies are ongoing around the globe to find a cure or prevention of the disease. The objective of the proposed study is to determine the efficacy and safety profile of Mulmina Mango as an adjunct to standard of care treatment on COVID-19 positive subjects undergoing treatment for COVID-19 in Hospital Quarantine. Settings and Design: The enrolled subjects were randomized into either of the two treatment arms in the ratio of 1:1. The freshly diagnosed (24-48 hrs.) COVID-19 positive Male or Female is aged 20 to 65 years (both inclusive) hospitalized patients were approached and checked for their eligibility. They were recruited after signing the written informed consent form. The number of patients included in the study is 48. In efficacy, both the treatment arms and the reduction in clinical symptom scale value and ordinal scale value are seen on day 7. On the ordinal scale, 41.7% of subjects in Treatment arm A showed a reduction of 2 points on the day, and 16.7% of subjects show 2 points reduction in Treatment arm B. In Safety results, there was no clinically significant finding in safety parameters in Treatment arm B. Mulmina Mango showed encouraging results concerning RTPCR, CRP, Dopamine, IgG, CD4, and CD8 parameters. The properties of Mulmina Mango are highlighted below, along with the parameters for each property. Mulmina Mango, COVID-19, Treatment Arm A, Treatment Arm B, MoHFW (Ministry of Health and Family Welfare)

Harmonising the human biobanking consent process: an Irish experience

Biobanks are repositories of human biological samples and data. They are an important component of clinical research in many disease areas and often represent the first step toward innovative treatments. For biobanks to operate, researchers need human participants to give their samples and associated health data. In Ireland, research participants must provide their freely given informed consent for their samples and data to be taken and used for research purposes. Biobank staff are responsible for communicating the relevant information to participants prior to obtaining their consent, and this communication process is supported by the Participant Information Leaflets and Informed Consent Form (PI/ICFs). PILs/ICFs should be concise, intelligible, and contain relevant information. While not a substitute for layperson and research staff discussions, PILs and ICFs ensure that a layperson has enough information to make an informed choice to participate or not. However, PILs/ICFs are often lengthy, contain technical language and can be complicated and onerous for a layperson to read. The introduction of the General Data Protection Regulation and the related Irish Health Research Regulation presented additional challenges to the Irish biobank community. In May 2019, the National Biobanking Working Group (NBWG) was established in Ireland. It consists of members from diverse research backgrounds located in universities, hospitals and research centres across Ireland and a public/patient partner. The NBWG aimed to develop a suite of resources for health research biobanks via robust and meaningful patient engagement, which are accessible, General Data Protection Regulation/Health Research Regulation-compliant and could be used nationally, including a PIL/ICF template. This open letter describes the process whereby this national biobank PIL/ICF template was produced. The development of this template included review by the Patient Voice in Cancer Research, led by Professor Amanda McCann at University College Dublin and the Health Research Data Protection Network.

Our Acupuncture Experıences in Patıents with Remarkable Leg Syndrome: Pilot Study

Restless legs syndrome (RLS) is a disease characterized by an undescribable abnormal sensation, a kind of dysesthesia, especially in the legs. It is characteristic for restless legs syndrome that the symptoms are circadian in nature, that is, they are more pronounced in the evening and at night, and occur or increase at rest. In response to these effects, when the effects of acupuncture on various systems and symptoms and the mechanisms of these effects are evaluated, the benefits of acupuncture in restless legs syndrome may be the subject of research. This study was carried out on patients who applied to Konya Necmettin Erbakan University Meram Medical Faculty Traditional and Complementary Medicine Center with the complaints of restless legs syndrome. In addition, nothing was requested from the participants. Informed consent form was obtained. Both body and ear acupuncture were applied for 10 sessions once a week. ST-33,34,35,GB-34, H-7LU-9,P-6,SI-3 points and shen-men,zero,knee on the ear , depression points were pricked. Electro acupuncture was applied for 20 minutes.) Pittsburgh sleep quality index scale questionnaire and john hopkins scale were applied to the participants before and after acupuncture. .Pittsburgh sleep quality index mean pre-acupuncture:35.5.Post acupuncture Pittsburgh sleep quality index mean:24. With the application of acupuncture, progress can be made in the treatment of restless legs syndrome that does not respond to conventional treatment.

The Effect of Micronutrient Intake on Cognitive Function and Physical Activity of the Elderly

Objectives: The purpose of this research was to investigate the effect of micronutrient intake on cognitive function and physical activity of the elderly. Methods: The subjects included all elderly people over 60 years of age in Robat Karim city in 2018. 90 elderly males participated voluntarily in the research after signing the informed consent form. The short form of Beck questionnaire of physical activity and MMSE test were respectively used to measure the levels of physical activity and cognitive status of participants. Pearson correlation test was used to analyze the data. Results: The results indicated that there was a significant relationship between each of the micronutrients and cognitive performance of the elderly (P ≤ 0.05). Additionally, there was a significant relationship between each of the micronutrients with the level of physical activity of the elderly (P ≤ 0.05). Conclusions: Conclusively, micronutrients intake could be of much importance for cognitive function and physical activity of the elderly.

Struggling With Extensive Informed Consent Procedures for Cancer Trails – Is There Even a Benefit for the Patients?

PurposeInformed consent procedures in clinical trials often differ in length and complexity to those in clinical routine care. Little is known about the benefit of extensive procedures as intended in clinical trials compared to procedures in routine cancer treatment. MethodsIn two different clinical studies performed at a comprehensive cancer center, we compared patients’ comprehension and satisfaction of current informed consent procedures in routine clinical care with the level of comprehension and satisfaction of patients treated within clinical trials. Patients with a new cancer diagnosis and recent informed consent received a questionnaire about satisfaction, comprehension, time management and physician-patient relationship of the informed consent process. Patients in cohort 1 consented to cancer treatment within a clinical trial and were additionally interviewed in a structured way; patients in cohort 2 consented to “standard” chemotherapy and received a follow-up questionnaire after 6 months. ResultsIn cohort 1, 82 patients completed the questionnaire and had an additional structured interview. They were treated in 41 different trials, receiving up to 40 pages of educational material. In cohort 2, 89 patients completed the first and 52 completed the follow-up questionnaire after receiving a standard informed consent form of 6 pages. Subjective understanding and satisfaction with the information provided was equally very high. However, deficits in objective understanding were observed in both cohorts. ConclusionExtensive informed consent procedures for clinical cancer trials have not been associated with a higher level of satisfaction or measurable objective understanding, therefore the benefit seems to be limited.

Postoperative analgesic efficacy of the thoracoabdominal nerves block through perichondrial approach (TAPA) and modified-TAPA for laparoscopic cholecystectomy: a randomized controlled study

Laparoscopic cholecystectomy is one of the most common surgical procedures. Even though there is less postoperative pain with laparoscopic cholecystectomy than with open cholecystectomy, severe pain can occur, particularly within the first 24 hours. Evaluation of the efficacy of ultrasound-guided interfascial plane blocks for postoperative analgesia of laparoscopic cholecystectomy has recently come to prominence. The aim of our study was to compare the postoperative analgesic efficacy of thoracoabdominal nerves block through perichondrial approach (TAPA) and modified-TAPA (m-TAPA) blocks in patients who underwent laparoscopic cholecystectomy. The present study included 56 patients who underwent laparoscopic cholecystectomy under general anesthesia and received TAPA or m-TAPA block for perioperative analgesia. Each patient signed a written informed consent form. Block times and numerical rating scale (NRS) scores 1, 2, 3, and 12 hours postoperatively, hourly and total tramadol amount of use via the patient-controlled analgesia device, and additional analgesic drug consumption were all recorded. The TAPA group had significantly longer block application times than the m-TAPA group. At 1 and 12 hours, NRS scores were lower in the TAPA group. However, the mean NRS scores, total tramadol use, and use of additional analgesics were comparable between the groups. TAPA and m-TAPA block methods reduced NRS scores by alleviating pain after laparoscopic cholecystectomy procedures, thereby reducing the need for additional analgesics. Block times for TAPA were significantly longer than those for m-TAPA. However, both block applications were completed in a short period, smoothly and safely. The analgesic effect of TAPA block was more distinctive at 1 and 12 hours, and NRS scores were lower. However, we think that both block methods, when used under ultrasound guidance, will provide effective analgesia by supplementing the multimodal analgesia planned for laparoscopic cholecystectomy and other abdominal operations.

ATTENTION DEFICIT HYPERACTIVITY DISORDER SYMPTOMS IN ADULTS WITH ESSENTIAL TREMOR

Background: Essential tremor is the most common movement disorder. İn this disease, which is characterized by tremor that increases with action and passes at rest, different accompanying symptoms can also be seen. Objective: The purpose of this study was to investigate attention deficit hyperactivity symptoms in adults with ET. Methods: Fifty six essential tremor patients and 56 controls were included in the study. Patients were recruited from outpatient clinic at Kirikkale University Medicine Faculty. An informed consent form was signed by each patient after detailed information. Institutional ethics committee approval was obtained. Patients’ characteristics such as education level, gender, age and disease duration were recorded. Symptoms of ADHD in patients and controls were determined by using the Adult Report Deficit / Hyperactivity Disorder Self Report Scale. Short Form-36 and Hospital Anxiety and Depression Scale were also performed. Essential tremor severity was determined by using the Whiget essential tremor scale. Results: Essential tremor patients had significantly higher rate of Adult Attention Disorder Self-Report Scale Deficit/Hyperactivity scores compared to controls. Scores of Adult Attention Deficit/Hyperactivity Disorder Self-Report Scale were associated with depression and anxiety scores and physical and mental component scores of Short Form-36 in bivariate analyses. There was a positive correlation between tremor severity and ASRS scores( ASRS A scores= 17,3±5,5, p=0,032, ASRS B scores= 27,7±6,7,p=0,043, ASRS T scores= 45±12,2, p=0,017) however there was no significant statistical relationship between the duration of disease and ASRS scores. Conclusion: This study showed that ADHD symptoms can be observed in adult essential tremor patients and this may be associated with increased psychosocial morbidity and lowered quality of life in ET patients.

Prevalence of Violation Among Nurses Working in Public Health Facilities in Saudi Arabia

Workplace violence (WPV) is more likely to affect those who work in community services, notably nurses. WPV is generally recognized as a workplace health hazard and has been a significant concern in a number of countries. Limited studies have been conducted in the global countries and this study was designed as a cross-sectional study from Saudi Arabia to document the WPV among the nurses. The aim of this study was to enroll the consequences obtain during the WPV among the nurses in Saudi Arabia. In this cross-sectional study, we have enrolled 550 nurses based on the signed of informed consent form and filled questionnaire. The study results indicated that 77.6% of nurses were violated at work. The 90.4% of the majority violations were classified as verbal abuse. The relatives of the patients violated 66.7% of the nurses, and the occurrence occurred during the evening shifts of the working hours between 2.30-10.30pm. The most violations occurred in the patient room, accounting for 46.8% of all violations, with the severe workload accounting for 89.2% of all violations. However, among the violations, 21.4% of the nurses were reported to senior management. In conclusion, this study confirms the nurses who have participated in this were mentally strong in handling the WPV during their job. Further studies are required for looking at the factors that increase the chance of a repeat event and those that decrease it, as well as development of an intervention program for the emotional load that accompanies WPV. To prevent workplace violence in healthcare settings, it is equally vital to implement policies that supplement the existing call to action.

Evaluation of Oral Health Condition among the Pregnant Females at Tertiary Care Hospital of Hyderabad, Sindh

Background: Gestational is special and interesting period for every woman that covers the physiological hormonal changes and leads to the development of new healthy life. Changes in hormones during pregnancy may alter the physiological conditions that impose the bad impact of different body parts including gastric and oral health of the mother. Oral health plays an important role for maintaining normal and healthy life of human being and if any disease or disorder appeared within the oral cavity, it may leads to severity of disease and disturbed normal routine life. Aims and Objectives: This study aims to evaluate the condition of oral health during gestational period. Materials and Methods: Descriptive cross sectional study was carried out for the period of six months at Department of Gynecology & Obstetrics ward, Liaquat University of Medical & Health Sciences, Jamshoro and females with positive pregnancy were included in the study and total 146 females were selected, after the signature on informed consent form. Medical history was taken in order to ensure any major disease or medication affecting oral health. Results: After collection of proper data from all participants, the results were finalized, 19 females were belonging to age group of 18-21years, and 51 females belong to 26-29 years. 47 females had good OHI-S score, 59 had fair OHI-S score. 31 female had 1st trimester, 81 females had 2nd trimester and 34 had 3rd trimester. 19 females had normal PI index, 94 had simple gingivitis and 33 females had periodontitis. Conclusion: It was important to maintain good oral hygiene before and during pregnancy, so as to prevent the occurrence of periodontal disease and to avert the irreparable damage that may arise during the period of pregnancy.

Motion Analysis of Long-Distance Drive in Woodball Athletes

The purpose of this study was to analyze the motion of long-distance drive in woodball athletes. The method in this study using quantitative descriptive using observation by Video Recording. The total sample used in this study 8 woodball athletes Semarang State University and all of them were willing to participate in the study by signing the informed consent form. This study uses data analysis techniques using the Kinovea application software Version 0.8.15. The results found that the preparation phase obtaining appropriate criteria, with an average score of 4. The prefix phase in this movement was of 3.8 with appropriate criteria and the implementation phase of 3.7 with appropriate criteria. The follow-through phase obtained an average score of 3.4 with almost appropriate criteria. Overall, the average in the motion analysis is 3.7 with the appropriate category. The conclusion of this study found that motion analysis of long-distance drive in woodball athletes are in the appropriate category. This study also showed quite effective and quite efficient based on the video analysis used. The limitation in this study still focuses on the kinetic data. Future research is expected to improve the quality of the drive and also minimize the occurrence of injuries.