Intrapartum epidural analgesia and emergency delivery rates due to fetal compromise by birth weight percentile

Abstract Objectives To investigate the association of calcium supplementation during the pregnancy with the birth weight of single-born neonates. Methods The survey employed a multistage, stratified and random sampling to investigate 15–49 aged pregnant women in 2010 to 2013 in Shaanxi province. A self - designed questionnaire was utilized. Birth weight between the 10(th) and 90(th) percentile was classified as appropriate for gestational age(AGA) infants. Chi-square test and logistic regression models were conducted to evaluate the association of calcium supplementation with single-born neonatal birth weight. Results A total of 28,490 women was enrolled in this study, 17 349 (60.9%) of participants had calcium supplementation during pregnancy. The incidence rates of small and large gestational age infants were 13.5% and 8.3%, respectively. The study conducted that calcium supplementation had a statistically significant difference in SGA (birth weight percentile <10) (P < 0.01). After adjusting the regression models by confounding factors, we found that calcium supplementation was still protective towards SGA birth, the difference was statistically significant (OR = 0.89, 95% CI: 0.82–0.96, P < 0.05), but there was no significant difference in the birth to LGA (birth weight percentile <10). Conclusions Calcium supplementation during pregnancy reduced the risk of SGA, but was not associated with the birth of LGA. Funding Sources

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Treatment of 139 Pregnancies in Antiphospholipid-positive Women Not Fulfilling Criteria for Antiphospholipid Syndrome: A Retrospective Study

The Journal of Rheumatology ◽

10.3899/jrheum.120576 ◽

2013 ◽

Vol 40 (4) ◽

pp. 425-429 ◽

Cited By ~ 31

Author(s):

Teresa Del Ross ◽

Amelia Ruffatti ◽

Maria Serena Visentin ◽

Marta Tonello ◽

Antonia Calligaro ◽

...

Keyword(s):

Birth Weight ◽

Pregnancy Outcome ◽

Gestational Age ◽

Pregnancy Loss ◽

Antiphospholipid Antibody ◽

Birth Weight Percentile ◽

Antibody Profile ◽

Gestational Age At Birth ◽

Age At Birth ◽

Weight Percentile

Objective.The effect of low-dose aspirin (LDA) on pregnancy outcome in antiphospholipid (aPL)-positive women not fulfilling the criteria for antiphospholipid antibody syndrome (APS) was evaluated retrospectively.Methods.We evaluated 139 pregnancies of 114 aPL-positive women not fulfilling the Sydney classification criteria for definite APS (104 treated with LDA, 35 untreated). Inclusion criteria consisted of (1) any titer of aPL and no previous pregnancy or no pregnancy losses (defined as aPL carriers); (2) any titer of aPL and 1 or 2 pregnancy losses before the 10th gestational week. No women had previous thrombosis. The rate of pregnancy loss, gestational age at delivery, and birth weight percentile were compared in the treated and untreated patients. Associations between clinical and laboratory characteristics and pregnancy outcomes were investigated.Results.The rate of pregnancy loss was low in both treated and untreated groups (7.7% vs 2.9%, respectively). There were no statistically significant differences in the rate of pregnancy loss, gestational age at birth, or birth weight percentile in the treated and untreated groups. There were significant associations between gestational age at birth ≤ 34th week and positivity for lupus anticoagulant (p = 0.025) and anti-ß2-glycoprotein I IgG antibodies at titers > 99th (p = 0.016).Conclusion.LDA treatment does not appear to improve pregnancy outcome in low-risk women not fulfilling the criteria for APS. Because antibody profile seems to influence pregnancy outcome, further studies of patients stratified according to their antibody profile are warranted.

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Association of placental volume measured by MRI and birth weight percentile

Journal of Magnetic Resonance Imaging ◽

10.1002/jmri.22794 ◽

2011 ◽

Vol 34 (5) ◽

pp. 1125-1130 ◽

Cited By ~ 23

Author(s):

Iris E. Derwig ◽

Ranjit Akolekar ◽

Fernando O. Zelaya ◽

Penny A. Gowland ◽

Gareth J. Barker ◽

...

Keyword(s):

Birth Weight ◽

Birth Weight Percentile ◽

Placental Volume ◽

Weight Percentile

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Associations between Maternal and Fetal Inherited Thrombophilias, Placental Characteristics Associated with Vascular Malperfusion, and Fetal Growth

TH Open ◽

10.1055/s-0037-1603925 ◽

2017 ◽

Vol 01 (01) ◽

pp. e43-e55

Author(s):

Alexa Freedman ◽

Carol Hogue ◽

Donald Dudley ◽

Robert Silver ◽

Barbara Stoll ◽

...

Keyword(s):

Birth Weight ◽

Rhode Island ◽

Fetal Growth ◽

Methylenetetrahydrofolate Reductase ◽

Factor V Leiden ◽

Factor V ◽

Factor V Leiden Mutation ◽

Maternal Factor ◽

Birth Weight Percentile ◽

Weight Percentile

AbstractPregnancy results in alterations in coagulation processes, which may increase the risk of thrombosis. Inherited thrombophilia mutations may further increase this risk, possibly through alterations in the placenta, which may result in pregnancy complications such as poor fetal growth. The purpose of our study is to evaluate the association of fetal growth, approximated by birth weight for gestational age percentile, with genetic markers of thrombophilia and placental characteristics related to vascular malperfusion. We analyzed data from the Stillbirth Collaborative Research Network's population-based case–control study conducted in 2006–2008. Study recruitment occurred in five states: Rhode Island and counties in Massachusetts, Georgia, Texas, and Utah. The analysis was restricted to singleton, nonanomalous live births ≤42 weeks' gestation with a complete placental examination and successful testing for ≥1 thrombophilia marker (858 mothers, 902 infants). Data were weighted to account for oversampling, differential consent, and availability of placental examination. We evaluated five thrombophilia markers: factor V Leiden, factor II prothrombin, methylenetetrahydrofolate reductase A1298C and C677T, and plasminogen activator inhibitor type 1 in both maternal blood and placenta/cord blood. We modeled maternal and fetal thrombophilia markers separately using linear regression. Maternal factor V Leiden mutation was associated with a 13.16-point decrease in adjusted birth weight percentile (95% confidence interval: −25.50, −0.82). Adjustment for placental abnormalities related to vascular malperfusion did not affect the observed association. No other maternal or fetal thrombophilia markers were significantly associated with birth weight percentile. Maternal factor V Leiden may be associated with fetal growth independent of placental characteristics.

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Optimal birth weight percentile cut-offs in defining small- or large-for-gestational-age

Acta Paediatrica ◽

10.1111/j.1651-2227.2009.01674.x ◽

2010 ◽

Vol 99 (4) ◽

pp. 550-555 ◽

Cited By ~ 50

Author(s):

H Xu ◽

F Simonet ◽

Z-C Luo

Keyword(s):

Birth Weight ◽

Gestational Age ◽

Large For Gestational Age ◽

Birth Weight Percentile ◽

Weight Percentile

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A need for an update of Polish birth weight reference norms

Anthropological Review ◽

10.2478/anre-2020-0006 ◽

2020 ◽

Vol 83 (1) ◽

pp. 43-51

Author(s):

Tomasz Hadada ◽

Magdalena Kosińska

Keyword(s):

Birth Weight ◽

Gestational Age ◽

Environmental Changes ◽

Prenatal Development ◽

Reference Standards ◽

Time Period ◽

Birth Weight Percentile ◽

Developmental Norms ◽

Weight Percentile ◽

Singleton Pregnancies

AbstractThe indicators of perinatal outcome are birth weight and gestational age. The standard method of assessing the outcome is comparing the newborn’s birth weight with the reference system, presented in the form of percentile charts. Acceleration or delay in prenatal development, which are associated with environmental changes, stress the need to validate the developmental norms. The goal of this study is to evaluate the need to construct new and accurate reference standards. The study includes data of newborns from singleton pregnancies: 4919 born in 2000 and 3683 born in 2015. Study variables included gestational age, sex, and birth weight. Percentile values estimated for two groups of infants born in years separated by a 15-year period, born in 2000 and in 2015, were compared. Birth weight percentiles, from the 28th to the 42nd week of gestation, were calculated using the Lambda Mu Sigma method. Estimated values revealed the birth weight standards in different weeks of gestational age for both years: 2000 and 2015. Comparison among medians estimated for infants born in these years showed the existence of significant differences among boys in the 28th, 36th, and 39th weeks and among girls in the 34th and 41st weeks of gestational age. As the period between the two measurements involves several years, environmental changes during this time period might have significantly affected the course of pregnancy and thus the birth weight. Hence, there is a need to validate the developmental norms. The reference standards should be renewed, and must be done on a periodical basis.

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A születési súlyok megoszlása 2011 és 2015 között és a percentilisértékek változása 1996 és 2015 között. A Tauffer-adatbázis feldolgozása

Orvosi Hetilap ◽

10.1556/650.2019.31481 ◽

2019 ◽

Vol 160 (36) ◽

pp. 1426-1436

Author(s):

László Zsirai ◽

M. György Csákány ◽

György Végh ◽

Gy. Ádám Tabák

Keyword(s):

Birth Weight ◽

Temporal Trends ◽

Live Births ◽

Birth Weight Percentile ◽

Gestational Week ◽

Using Data ◽

Substantial Change ◽

Twin Pregnancies ◽

A Current ◽

Weight Percentile

Abstract: Introduction and aim: We aimed to provide a current birth weight percentile table for singleton and twin pregnancies stratified by gestational week at delivery and sex using data from all live births in Hungary between 2011 and 2015. In addition, we examined temporal trends in average birth weights in singleton and twin pregnancies by sex in five-year periods between 1996 and 2015. Method: We calculated the 5th, 10th, 25th, 50th, 75th, 90th, and 95th centiles of birth weight for each gestational week by sex for singleton and twin pregnancies using compulsory collected obstetrical data (Tauffer Statistics) in Hungary in 2011–2015. Furthermore, we described changes in birth weights by gestational week between 5-year periods from 1996 to 2015. Results: We present birth weight centiles for live births in both tabular and graphical forms using data from 2011 to 2015. In general, live birth weights in gestational weeks 35–41 were lower in the period of 1996–2005 (the lowest in 1996–2000) and were higher in the period of 2006–2010 compared to the reference period of 2011–2015 (e.g., the average male newborn weighed 3249 g at gestational week 38 in 2011–2015, which is 34.3 [SE at 3.0] g less in 1996–2000, 11.5 [2.9] g less in 2001–2005, and 18.1 [2.9] g more in 2006–2010). Similar trends were not observed in birth weights of twin pregnancies in gestational weeks 35–38. Conclusion: Given the observed substantial change in birth weights during the past 20 years, renewal of the commonly used percentile tables is necessary. Birth weights increased from 1996 to 2010, mainly of mature newborns, followed by a stabilization or slight decrease in the later periods. Orv Hetil. 2019; 160(36): 1426–1436.

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Adverse Outcomes among Low-Risk Pregnancies at 39 to 41 Weeks: Stratified by Birth Weight Percentile

American Journal of Perinatology ◽

10.1055/s-0040-1709673 ◽

2020 ◽

Author(s):

Hector Mendez-Figueroa ◽

Han Yang Chen ◽

Suneet P. Chauhan

Keyword(s):

Birth Weight ◽

Adverse Outcome ◽

Mode Of Delivery ◽

Vital Statistics ◽

Adverse Outcomes ◽

Low Risk ◽

Secondary Outcome ◽

Adjusted Relative Risk ◽

Birth Weight Percentile ◽

Weight Percentile

Abstract Objective This study aimed to assess the risk of adverse outcomes among low-risk pregnancies at 39 to 41 weeks, stratified by birth weight percentile. Study Design This retrospective cohort study utilized the U.S. vital statistics datasets (2013–2017) and evaluated low-risk women with nonanomalous cephalic singleton gestations who labored and delivered at 39 to 41 weeks, regardless of ultimate mode of delivery. Newborns were categorized as small (<10th percentile), large (>90th percentile), or appropriate (10–90th percentile) for gestational ages (SGA, LGA, and AGA, respectively). The primary outcome, composite neonatal adverse outcome (CNAO), included Apgar's score <5 at 5 minutes, assisted ventilation >6 hours, seizure, or neonatal death. The secondary outcome, composite maternal adverse outcome (CMAO), included intensive care unit admission, blood transfusion, uterine rupture, or unplanned hysterectomy. Multivariable Poisson's regression was used to estimate the association (using adjusted relative risk [aRR] and 95% confidence interval [CI]). Results Of 19.8 million live births during the study interval, approximately 8.9 million (44.9%) met the inclusion criteria, with 9.9% being SGA, 9.2% being LGA, and 80.9% being AGA. SGA newborns delivered at 40 (aRR = 1.17; 95% CI: 1.12–1.23) and at 41 weeks (aRR = 1.55; 95% CI: 1.45–1.66) had a higher risk of CNAO than at 39 weeks. Similarly, LGA newborns delivered at 40 (aRR = 1.13; 95% CI: 1.07–1.19) and 41 weeks (aRR = 1.44; 95% CI: 1.35–1.54) and AGA newborns delivered at 40 (aRR = 1.24; 95% CI: 1.21–1.26) and 41 weeks (aRR = 1.57; 95% CI: 1.53–1.61) also had a higher risk of CNAO than at 39 weeks. CMAO was also significantly higher at 40 and 41 weeks than at 39 weeks, regardless of whether the mothers delivered SGA, LGA, or AGA newborns. Conclusion Among low-risk pregnancies, the risks of composite neonatal and maternal adverse outcomes increase from 39 through 41 weeks' gestation, irrespective of whether newborns are SGA, LGA, or AGA.

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