scholarly journals Hemostasis management of tooth extraction in a patient with Bernard–Soulier syndrome and a severe bleeding tendency: A case report

2015 ◽  
Vol 27 (4) ◽  
pp. 525-528 ◽  
Author(s):  
Sayaka Mishima ◽  
Kazumasa Nakao ◽  
Masayuki Ikeno ◽  
Kazuhisa Bessho
Keyword(s):  
Case Report ◽  
Tooth Extraction ◽  
Severe Bleeding ◽  
Bleeding Tendency ◽  
Bernard Soulier Syndrome

Heparin-free adventitia pulmonary oxygenation in the treatment of trauma complicated with severe pulmonary infection: a case report

Perfusion ◽  
2021 ◽  
pp. 026765912098408
Author(s):  
Gu Qiao ◽  
Xiao-Kang Zeng ◽  
Xiang-Ying Yang ◽  
Meng-Yuan Diao ◽  
Ying Zhu ◽  
...  
Keyword(s):  
Case Report ◽  
Pulmonary Infection ◽  
Cervical Spinal Cord ◽  
Femoral Vein ◽  
Severe Bleeding ◽  
Bleeding Tendency ◽  
Cord Injury ◽  
Internal Jugular Vein Catheterization ◽  
Vv Ecmo ◽  
Vein Catheterization

The application of Venovenous (VV) extracorporeal membrane oxygenation (ECMO) in trauma and patients with severe bleeding tendency has been controversial. However, VV ECMO without anticoagulation contributes to reducing the risk of bleeding during ECMO maintenance. VV ECMO serves critical roles in therapy of patients with severe pulmonary infection and failure in conventional therapy. The common peripheral catheterization approach for VV ECMO is femoral vein-internal jugular vein catheterization, and bilateral femoral vein catheterization can also achieve the purpose of respiratory support for patients with limited cervical catheterization. In this case report, we described a patient with post-traumatic cervical spinal cord injury and severe pulmonary infection who was successfully treated with heparin-free intravenous ECMO.

Inhibitor treatment by rituximabin congenital haemophilia A

2009 ◽  
Vol 29 (02) ◽  
pp. 151-154 ◽  
Author(s):  
Escuriola Ettingshausen ◽  
R. Linde ◽  
G. Kropshofer ◽  
L.-B. Zimmerhackl ◽  
W. Kreuz ◽  
...  
Keyword(s):  
B Cell ◽  
Immune Tolerance ◽  
High Titre ◽  
Clotting Factor ◽  
Severe Bleeding ◽  
High Morbidity ◽  
Haemophilia A ◽  
Concomitant Treatment ◽  
Bleeding Tendency ◽  
Severe Haemophilia

SummaryThe development of neutralizing alloanti-bodies (inhibitors) to factor VIII (FVIII) is one of the most serious complications in the treatment of haemophiliacs. Inhibitors occur in approximately 20 to 30% of previously untreated patients (PUPs), predominantly children, with severe haemophilia A within the first 50 exposure days (ED). Immune tolerance induction (ITI) leads to complete elimination of the inhibitor in up to 80% of the patients and offers the possibility to restore regular FVIII prophylaxis. However, patients with high titre inhibitors, in whom standard ITI fails, usually impose with high morbidity and mortality and therefore prompting physicians to alternate therapy regimens. Rituximab, an anti-CD 20 monoclonal antibody has been successfully used in children and adults for the management of B-cell mediated disorders. We report on the use of a new protocol including rituximab in two adolescents with severe haemophilia A and high titre inhibitors, severe bleeding tendency and high clotting factor consumption after failing standard ITI. Both patients received a concomitant treatment with FVIII according to the Bonn protocol, cyclosporine A and immunoglobulin. Treatment with rituximab resulted in a temporary B-cell depletion leading to the disappearance of the inhibitor. FVIII recovery and half-life turned towards normal ranges. In patient 1 the inhibitor reappeared 14 months after the last rituximab administration. In patient 2 complete immune tolerance could be achieved for 60 months. Bleeding frequency diminished significantly and clinical joint status improved in both patients. In patient 1 the treatment course was complicated by aspergillosis and hepatitis B infection. Conclusion: Rituximab may be favourable for patients with congenital haemophilia, high-titre inhibitors and a severe clinical course in whom standard ITI has failed. Prospective studies are required to determine safety, efficacy and predictors of success.

Autoantibody Selectively Inhibits Binding of von Willebrand Factor to Glycoprotein Ib. Recognition Site Is Located in the A1 Loop of von Willebrand Factor

1997 ◽  
Vol 77 (04) ◽  
pp. 760-766 ◽  
Author(s):  
Hiroshi Mohri ◽  
Etsuko Yamazaki ◽  
Zekou Suzuki ◽  
Toshikuni Takano ◽  
Shumpei Yokota ◽  
...  
Keyword(s):  
Von Willebrand Factor ◽  
Significant Inhibition ◽  
Von Willebrand Disease ◽  
Recognition Site ◽  
Severe Bleeding ◽  
Bleeding Tendency ◽  
Virtual Absence ◽  
Heavy Chains ◽  
Von Willebrand ◽  
Willebrand Factor

SummaryA 20-year-old man with severe von Willebrand disease recently presented a progressive bleeding tendency, characterized recurrent subcutaneous hemorrhages and cerebral hemorrhage. Mixing and infusion studies suggested the presence of an inhibitor directed against vWF:RCo activity of von Willebrand factor (vWF) without significant inhibition of the FVIII:C. The inhibitor was identified as an antibody of IgG class. The inhibitor inhibited the interaction of vWF in the presence of ristocetin and that of asialo-vWF with GPIb while it partially blocked botrocetin-mediated interaction of vWF to GPIb. The inhibitor reacted with native vWF, the 39/34kDa fragment (amino acids [aa] 480/ 481-718) and the recombinant vWF fragment (MalE-rvWF508-704), but not with Fragment III-T2 (heavy chains, aa 273-511; light chains, aa 674-728). A synthetic peptide (aa 514-542) did not inhibit vWF-inhibitor complex formation. We conclude that this is the first autoantibody of class IgG from human origin that recognizes the sequence in the A1 loop of vWF, resulting in a virtual absence of functional vWF and a concomitant severe bleeding tendency although recognition site is different from the residues 514-542 which is crucial for vWF-GPIb interaction.

Aneurysm of the communicating vein between the left renal vein and left ascending lumbar vein mimicking a retroperitoneal lymphadenopathy: A case report

2020 ◽  
Vol 16 ◽  
Author(s):  
Sevtap Arslan ◽  
Yasin Sarıkaya ◽  
Musturay Karcaaltincaba ◽  
Ali Devrim Karaosmanoglu
Keyword(s):  
Case Report ◽  
Lymph Nodes ◽  
Testicular Cancer ◽  
Renal Vein ◽  
Medical Center ◽  
Left Renal Vein ◽  
Severe Bleeding ◽  
Lumbar Vein ◽  
Ascending Lumbar Vein ◽  
Communicating Vein

Introduction: Aneurysm of the communicating vein between the left renal vein and left ascending lumbar vein is extremely rare with only anecdotal reported cases. Unless detected and recognized promptly, this rare condition may give rise to severe bleeding in patients undergoing retroperitoneal surgery. It may also closely mimic enlarged retroperitoneal lymph nodes, paragangliomas, adrenal masses, or renal artery aneurysms. Case report: In this case study, we reported the imaging findings of this rare entity which was falsely diagnosed as enlarged retroperitoneal lymph node in an outside medical center, reported as to be consistent with metastatic disease, in a patient with newly diagnosed testicular cancer. Conclusion: The aneurysm of the communicating vein should be considered in the differential diagnosis in patients with testicular cancer and other disease processes where lymph nodes are commonly affected.

scholarly journals IgM multiple myeloma presenting with bleeding tendency: a case report with immunophenotype analysis

2010 ◽  
Vol 2 (1) ◽  
pp. 55-57 ◽  
Author(s):  
LING ZHENG ◽  
ZHIYONG ZENG ◽  
JUNFANG LIN ◽  
JUNMIN CHEN
Keyword(s):  
Multiple Myeloma ◽  
Case Report ◽  
Bleeding Tendency

scholarly journals Management of recurrent peripheral giant cell granuloma -a case report

2016 ◽  
Vol 4 (2) ◽  
pp. 138
Author(s):  
Santha Kumari Prathypaty ◽  
Santhi Priya Potharaju ◽  
Ravi Kanth Chintala ◽  
Satheesh Kumar Guvvala ◽  
Jai Krishna Srikanth Kolliboyana
Keyword(s):  
Case Report ◽  
Giant Cell ◽  
Chronic Infection ◽  
Tooth Extraction ◽  
Benign Tumor ◽  
Surgical Excision ◽  
Giant Cell Granuloma ◽  
Complete Excision ◽  
Periodontal Membrane ◽  
Peripheral Giant Cell Granuloma

Peripheral giant cell granuloma (PGCG) which is also called as Giant cell Epulis is one of the most common reactive hyperplastic lesions of the oral cavity. There are various etiologies relating PGCG which include local irritation, trauma, tooth extraction, irregular restorations, plaque, calculus, chronic infection & impacted food. One important other etiology of this benign tumor is its origin from periosteum or periodontal membrane. Excision of the lesion completely along with extraction of involved tooth is the option of treatment to prevent recurrence of the lesion in some cases. This case report describes the recurrence of the Peripheral giant cell granuloma even after complete excision in 3 months.Management of recurrent Peripheral giant cell granuloma by surgical excision of the lesion was carried out along with extraction of the associated tooth and curettage of the bone walls. Profuse bleeding after tooth extraction was managed by gel-spun. Periodic recalls doesn’t show any recurrence until one month.

scholarly journals Maxillary sinus aspergillosis: A case report of the timely failure to treatment

2019 ◽  
Author(s):  
Asma Beyki ◽  
Mahmud Zardast ◽  
Zahra Nasrollahi
Keyword(s):  
Case Report ◽  
Invasive Aspergillosis ◽  
Maxillary Sinus ◽  
Paranasal Sinuses ◽  
Tooth Extraction ◽  
Histopathological Examination ◽  
Maxillary Sinusitis ◽  
Eye Pain ◽  
Lower Jaw ◽  
The Right

Invasive aspergillosis of the paranasal sinuses is a rare and often misdiagnosed disease. This study reported a case of max- illary aspergillosis with a complete  headache and eye pain after tooth extraction with a large abscess in the relative jaw. Tenderness in the right temporal, lower jaw numbness and right eye proptosis was found. Histopathological examination was the suggestion of maxillary sinusitis with a fungal ball of aspergillus.

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