A pilot study: Clinical efficacy of novel polycaprolactone-tricalcium phosphate membrane for guided bone regeneration in rabbit calvarial defect model

2018 ◽  
Vol 30 (3) ◽  
pp. 212-219 ◽  
Author(s):  
Leonardo Saigo ◽  
Vinoth Kumar ◽  
Yuchun Liu ◽  
Jing Lim ◽  
Swee Hin Teoh ◽  
...  
Keyword(s):  
Pilot Study ◽  
Bone Regeneration ◽  
Clinical Efficacy ◽  
Tricalcium Phosphate ◽  
Guided Bone Regeneration ◽  
Calvarial Defect ◽  
Defect Model

Melatonin decorated 3D-printed beta-tricalcium phosphate scaffolds promoting bone regeneration in a rat calvarial defect model

2019 ◽  
Vol 7 (20) ◽  
pp. 3250-3259 ◽  
Author(s):  
Yali Miao ◽  
Yunhua Chen ◽  
Xiao Liu ◽  
Jingjing Diao ◽  
Naru Zhao ◽  
...  
Keyword(s):  
Bone Regeneration ◽  
Tricalcium Phosphate ◽  
Calvarial Defect ◽  
Defect Model ◽  
Beta Tricalcium Phosphate ◽  
3D Printed ◽  
Rat Calvarial Defect

3D-printed β-TCP scaffolds decorated with melatonin via dopamine mussel-inspired chemistry enhance the osteogenesis and in vivo bone regeneration.

Porous 3D Printed Scaffolds For Guided Bone Regeneration In a Rat Calvarial Defect Model

2020 ◽  
Vol 20 ◽  
pp. 100706 ◽  
Author(s):  
Hoang Phuc Dang ◽  
Cedryck Vaquette ◽  
Tara Shabab ◽  
Román A. Pérez ◽  
Ying Yang ◽  
...  
Keyword(s):  
Bone Regeneration ◽  
Guided Bone Regeneration ◽  
Calvarial Defect ◽  
Defect Model ◽  
3D Printed ◽  
Rat Calvarial Defect

Porosity effect of 3D-printed polycaprolactone membranes on calvarial defect model for guided bone regeneration

2017 ◽  
Vol 13 (1) ◽  
pp. 015014 ◽  
Author(s):  
Jin-Hyung Shim ◽  
Jae-hyang Jeong ◽  
Joo-Yun Won ◽  
Ji-Hyeon Bae ◽  
Geunseon Ahn ◽  
...  
Keyword(s):  
Bone Regeneration ◽  
Guided Bone Regeneration ◽  
Calvarial Defect ◽  
Defect Model ◽  
Porosity Effect ◽  
3D Printed

scholarly journals The Release of the Bromodomain Ligand N,N-Dimethylacetamide Adds Bioactivity to a Resorbable Guided Bone Regeneration Membrane in a Rabbit Calvarial Defect Model

Materials ◽  
2020 ◽  
Vol 13 (3) ◽  
pp. 501 ◽  
Author(s):  
Barbara Siegenthaler ◽  
Chafik Ghayor ◽  
Nisarat Ruangsawasdi ◽  
Franz E. Weber
Keyword(s):  
Drug Delivery ◽  
Bone Regeneration ◽  
Guided Bone Regeneration ◽  
Good Combination ◽  
Calvarial Defect ◽  
Delivery Vehicle ◽  
Defect Model ◽  
Therapeutic Benefits ◽  
Biodegradable Poly

N,N-Dimethylacetamide (DMA) is FDA approved as an excipient and is used as drug-delivery vehicle. Due to its amphipathic nature and diverse bioactivities, it appears to be a good combination of biodegradable poly-lactide-co-glycolide (PLGA)-based guided bone regeneration membranes. Here we show that the solvent DMA can be loaded to PLGA membranes by different regimes, leading to distinct release profiles, and enhancing the bone regeneration in vivo. Our results highlight the potential therapeutic benefits of DMA in guided bone regeneration procedures, in combination with biodegradable PLGA membranes.

scholarly journals Bone Regeneration by Dedifferentiated Fat Cells Using Composite Sponge of Alfa-Tricalcium Phosphate and Gelatin in a Rat Calvarial Defect Model

2021 ◽  
Vol 11 (24) ◽  
pp. 11941
Author(s):  
Nobuhito Tsumano ◽  
Hirohito Kubo ◽  
Rie Imataki ◽  
Yoshitomo Honda ◽  
Yoshiya Hashimoto ◽  
...  
Keyword(s):  
Bone Regeneration ◽  
Tricalcium Phosphate ◽  
Electrostatic Interactions ◽  
Bone Defects ◽  
Gelatin Sponge ◽  
Calvarial Defect ◽  
Micro Computed Tomography ◽  
Defect Model ◽  
Rat Calvarial Defect ◽  
Dfat Cells

Mechanical and resorbable scaffolds are in high demand for stem cell-based regenerative medicine, to treat refractory bone defects in craniofacial abnormalities and injuries. Multipotent progenitor cells, such as dedifferentiated fat (DFAT) cells, are prospective sources for regenerative therapies. Herein, we aimed to demonstrate that a composite gelatin sponge (α-TCP/GS) of alfa-tricalcium phosphate (α-TCP) mixed with gelatin scaffolds (GS), with/without DFATs, induced bone regeneration in a rat calvarial defect model in vivo. α-TCP/GS was prepared by mixing α-TCP and 2% GS using vacuum-heated methods. α-TCP/GS samples with/without DFATs were transplanted into the model. After 4 weeks of implantation, the samples were subjected to micro-computed tomography (μ-CT) and histological analysis. α-TCP/GS possessed adequate mechanical strength; α-TCP did not convert to hydroxyapatite upon contact with water, as determined by X-ray diffraction. Moreover, stable α-TCP/GS was formed by electrostatic interactions, and verified based on the infrared peak shifts. μ-CT analyses showed that bone formation was higher in the α-TCP/GS+ DFAT group than in the α-TCP/GS group. Therefore, the implantation of α-TCP/GS comprising DFAT cells enhanced bone regeneration and vascularization, demonstrating the potential for healing critical-sized bone defects.

scholarly journals The Effect of Silk Membrane Plus 3% 4-hexylresorcinol on Guided Bone Regeneration in a Rabbit Calvarial Defect Model

2013 ◽  
Vol 27 (1) ◽  
pp. 209-217 ◽  
Author(s):  
Hyun Seok ◽  
Sang-Woon Lee ◽  
Seong-Gon Kim ◽  
Dong-Hyun Seo ◽  
Han Sung Kim ◽  
...  
Keyword(s):  
Bone Regeneration ◽  
Guided Bone Regeneration ◽  
Calvarial Defect ◽  
Defect Model

scholarly journals Bacterial cellulose-hydroxyapatite composites with osteogenic growth peptide (OGP) or pentapeptide OGP on bone regeneration in critical-size calvarial defect model

2015 ◽  
Vol 103 (10) ◽  
pp. 3397-3406 ◽  
Author(s):  
Suzane C. Pigossi ◽  
Guilherme J. P. L. de Oliveira ◽  
Livia S. Finoti ◽  
Rafael Nepomuceno ◽  
Luis Carlos Spolidorio ◽  
...  
Keyword(s):  
Bone Regeneration ◽  
Bacterial Cellulose ◽  
Critical Size ◽  
Calvarial Defect ◽  
Defect Model
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