Phototherapies including photothermal therapy (PTT) and photodynamic therapy (PDT) have gained considerable attention due to their high tumor ablation efficiency, excellent spatial resolution and minimal side effects on normal tissue.
A sialic acid-targeted near-infrared profluorophore with pH-responsive fluorescence and photothermal properties was developed for fluorescence-guided staging and photothermal therapy of viable tumors exposed during surgery.
The first molecular material-based PTA for the NIR-II photothermal therapy with high PCE of 58.3% was reported. The Zn4-H2Pc/DP NPs reveal good biocompatibility and notable tumor ablation ability in 1064 nm.