Relationship between the serotonin transporter polymorphism and obsessive–compulsive alcohol craving in alcohol-dependent adults: a pilot study

Zusammenfassung. Hintergrund: Alkoholabhängige Patienten berichten häufig von einem starken Verlangen nach Alkohol (alcohol craving). Die Ergebnisse experimenteller Untersuchungen lassen vermuten, dass Ängstlichkeit und Depressivität mit stärkerem Craving einhergehen. Darüber hinaus kann vorausgesetzt werden, dass Intensität und Häufigkeit des Verlangens nach Alkohol im Verlauf einer stationären Behandlung deutlich abnehmen. Fragestellung: Lässt sich die Konstruktvalidität einer deutschsprachigen Version der Obsessive Compulsive Drinking Scale (OCDS) empirisch belegen? Methode: Am ersten, siebten und 14. Tag nach Beginn einer stationäreren Behandlung wurde alkoholabhängigen Patienten (N = 41) jeweils eine deutschsprachige Version der OCDS sowie der Symptom-Checkliste von Derogatis vorgelegt. Ergebnisse: Das von den Patienten berichtete Verlangen nach Alkohol nahm im Verlauf der stationären Behandlung deutlich ab, Ängstlichkeit und Depressivität gingen jedoch nicht mit stärkerem Verlangen einher. Schlussfolgerungen: Möglicherweise bildet eine wöchentliche Erfassung die starken Schwankungen des Verlangens während des akuten Entzugs nicht adäquat ab.

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A Non-Interventional Pilot Study to Explore the Role of Gut Flora in Obsessive-Compulsive Disorder

Case Medical Research ◽

10.31525/ct1-nct04211402 ◽

2019 ◽

Author(s):

Keyword(s):

Pilot Study ◽

Obsessive Compulsive Disorder ◽

Gut Flora ◽

Obsessive Compulsive ◽

Compulsive Disorder

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Faculty Opinions recommendation of Serotonin transporter polymorphism moderates effects of prenatal maternal anxiety on infant negative emotionality.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.10533956.11381054 ◽

2011 ◽

Author(s):

Donatella Marazziti

Keyword(s):

Serotonin Transporter ◽

Negative Emotionality ◽

Maternal Anxiety ◽

Serotonin Transporter Polymorphism

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Faculty Opinions recommendation of Enhanced negative emotion and alcohol craving, and altered physiological responses following stress and cue exposure in alcohol dependent individuals.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1159802.621218 ◽

2009 ◽

Author(s):

George Breese ◽

Mary Katherine Kelm

Keyword(s):

Negative Emotion ◽

Physiological Responses ◽

Cue Exposure ◽

Alcohol Craving ◽

Alcohol Dependent

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Elevated Expression of SLC6A4 Encoding the Serotonin Transporter (SERT) in Gilles de la Tourette Syndrome

Genes ◽

10.3390/genes12010086 ◽

2021 ◽

Vol 12 (1) ◽

pp. 86

Author(s):

Mathis Hildonen ◽

Amanda M. Levy ◽

Christina Dahl ◽

Victoria A. Bjerregaard ◽

Lisbeth Birk Møller ◽

...

Keyword(s):

Tourette Syndrome ◽

Serotonin Transporter ◽

Neurodevelopmental Disorder ◽

Control Group ◽

Obsessive Compulsive ◽

Expression Levels ◽

Compulsive Disorder ◽

Hyperactivity Disorder ◽

Elevated Expression ◽

Gene Expression Levels

Gilles de la Tourette syndrome (GTS) is a complex neurodevelopmental disorder characterized by motor and vocal tics. Most of the GTS individuals have comorbid diagnoses, of which obsessive-compulsive disorder (OCD) and attention deficit-hyperactivity disorder (ADHD) are the most common. Several neurotransmitter systems have been implicated in disease pathogenesis, and amongst these, the dopaminergic and the serotonergic pathways are the most widely studied. In this study, we aimed to investigate whether the serotonin transporter (SERT) gene (SLC6A4) was differentially expressed among GTS individuals compared to healthy controls, and whether DNA variants (the SERT-linked polymorphic region 5-HTTLPR, together with the associated rs25531 and rs25532 variants, and the rare Ile425Val variant) or promoter methylation of SLC6A4 were associated with gene expression levels or with the presence of OCD as comorbidity. We observed that SLC6A4 expression is upregulated in GTS individuals compared to controls. Although no specific genotype, allele or haplotype was overrepresented in GTS individuals compared to controls, we observed that the LAC/LAC genotype of the 5-HTTLPR/rs25531/rs25532 three-locus haplotype was associated with higher SLC6A4 mRNA expression levels in GTS individuals, but not in the control group.

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