Alcohol dependence alters substance P/neurokinin 1 receptor signaling in the central nucleus of the amygdala

Alcohol ◽  
2017 ◽  
Vol 60 ◽  
pp. 228
Author(s):  
S. Khom ◽  
K.C. Rice ◽  
M. Roberto
Keyword(s):  
Substance P ◽  
Alcohol Dependence ◽  
Central Nucleus ◽  
Receptor Signaling ◽  
Neurokinin 1 Receptor ◽  
Neurokinin 1

scholarly journals Alcohol dependence potentiates substance P/neurokinin-1 receptor signaling in the rat central nucleus of amygdala

2020 ◽  
Vol 6 (12) ◽  
pp. eaaz1050
Author(s):  
S. Khom ◽  
T. Steinkellner ◽  
T. S. Hnasko ◽  
M. Roberto
Keyword(s):  
Substance P ◽  
Alcohol Dependence ◽  
Critical Role ◽  
Alcohol Exposure ◽  
Gaba Release ◽  
Central Nucleus ◽  
Neurokinin 1 Receptor ◽  
Neurokinin 1 ◽  
Gaba Transmission ◽  
Alcohol Dependent

Behavioral and clinical studies suggest a critical role of substance P (SP)/neurokinin-1 receptor (NK-1R) signaling in alcohol dependence. Here, we examined regulation of GABA transmission in the medial subdivision of the central amygdala (CeM) by the SP/NK-1R system, and its neuroadaptation following chronic alcohol exposure. In naïve rats, SP increased action potential–dependent GABA release, and the selective NK-1R antagonist L822429 decreased it, demonstrating SP regulation of CeM activity under basal conditions. SP induced a larger GABA release in alcohol-dependent rats accompanied by decreased NK-1R expression compared to naïve controls, suggesting NK-1R hypersensitivity which persisted during protracted alcohol withdrawal. The NK-1R antagonist blocked acute alcohol-induced GABA release in alcohol-dependent and withdrawn but not in naïve rats, indicating that dependence engages the SP/NK-1R system to mediate acute effects of alcohol. Collectively, we report long-lasting CeA NK-1R hypersensitivity corroborating that NK-1Rs are promising targets for the treatment of alcohol use disorder.

Sa1700 Inhibition of the Substance P/Neurokinin 1 Receptor Signaling Axis Reduces Cholangiocarcinoma Growth In Vivo

2014 ◽  
Vol 146 (5) ◽  
pp. S-954
Author(s):  
Shannon Glaser ◽  
Sharon DeMorrow ◽  
Fanyin Meng ◽  
Julie Venter ◽  
Holly A. Standeford ◽  
...  
Keyword(s):  
Substance P ◽  
Receptor Signaling ◽  
Neurokinin 1 Receptor ◽  
Signaling Axis ◽  
Neurokinin 1

Crosstalk between neurokinin receptor signaling and neuroinflammation in neurological disorders

2019 ◽  
Vol 30 (3) ◽  
pp. 233-243
Author(s):  
Prasanth M. Eapen ◽  
Chamallamudi Mallikarjuna Rao ◽  
Madhavan Nampoothiri
Keyword(s):  
Substance P ◽  
Intracellular Signaling ◽  
Neural Circuit ◽  
Receptor Signaling ◽  
Signaling Mechanism ◽  
Neurokinin 1 Receptor ◽  
Physiological Processes ◽  
Neurokinin Receptor ◽  
Brain Substance ◽  
Neurokinin 1

AbstractThe neurokinin 1 receptor with the natural substrate substance P is one of the intensely studied receptors among the neurokinin receptors. The intracellular signaling mechanism uses G protein-coupled transduction regulating various physiological processes from nausea to Alzheimer’s disease. The neurokinin 1 receptor plays a significant role in neuroinflammation-mediated alterations in neural circuitry. Neurokinin 1 receptor antagonists are selective, potent and exhibited efficacy in animal models of nervous system disorders. Evolving data now strengthen the viewpoint of brain substance P/neurokinin 1 receptor axis-mediated action in neural circuit dysfunction. Thus, a deep-rooted analysis of disease mechanism in which the neurokinin 1 receptor is involved is necessary for augmenting disease models which encourage the pharmaceutical industry to intensify the research pipeline. This review is an attempt to outline the concept of neurokinin 1 receptor signaling interlinked to the brain innate immune system. We also uncover the mechanisms of the neurokinin 1 receptor involved in neurological disorder and various methods of modulating the neurokinin 1 receptor, which may result in therapeutic action.

scholarly journals Substance P mediates inflammatory oedema in acute pancreatitis via activation of the neurokinin-1 receptor in rats and mice

2000 ◽  
Vol 130 (3) ◽  
pp. 505-512 ◽  
Author(s):  
Eileen F Grady ◽  
Shandra K Yoshimi ◽  
John Maa ◽  
Dahlia Valeroso ◽  
Robert K Vartanian ◽  
...  
Keyword(s):  
Acute Pancreatitis ◽  
Substance P ◽  
Neurokinin 1 Receptor ◽  
Neurokinin 1 ◽  
Rats And Mice

scholarly journals Substance P enhances HIV-1 infection in human fetal brain cell cultures expressing full-length neurokinin-1 receptor

2013 ◽  
Vol 19 (3) ◽  
pp. 219-227 ◽  
Author(s):  
Lynnae Schwartz ◽  
Sergei V. Spitsin ◽  
John Meshki ◽  
Florin Tuluc ◽  
Steven D. Douglas ◽  
...  
Keyword(s):  
Substance P ◽  
Cell Cultures ◽  
Fetal Brain ◽  
Brain Cell ◽  
Full Length ◽  
Human Fetal Brain ◽  
Neurokinin 1 Receptor ◽  
Brain Cell Cultures ◽  
Neurokinin 1 ◽  
Hiv 1

Action of substance P (neurokinin-1) receptor activation on rat neostriatal projection neurons

Synapse ◽  
1999 ◽  
Vol 33 (1) ◽  
pp. 26-35 ◽  
Author(s):  
Elvira Galarraga ◽  
Salvador Hern�ndez-L�pez ◽  
Dagoberto Tapia ◽  
Arturo Reyes ◽  
Jos� Bargas
Keyword(s):  
Substance P ◽  
Receptor Activation ◽  
Projection Neurons ◽  
Neurokinin 1 Receptor ◽  
Neurokinin 1

scholarly journals Analgesia by deletion of spinal neurokinin 1 receptor expressing neurons using a bioengineered substance P-Pseudomonas exotoxin conjugate

2017 ◽  
Vol 13 ◽  
pp. 174480691772765 ◽  
Author(s):  
Michael J Iadarola ◽  
Matthew R Sapio ◽  
Xunde Wang ◽  
Hector Carrero ◽  
Maria Luisa Virata-Theimer ◽  
...  
Keyword(s):  
Substance P ◽  
Pseudomonas Exotoxin ◽  
Neurokinin 1 Receptor ◽  
Neurokinin 1
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