In vitro effect of antibiotics on biofilm formation by Bacteroides fragilis group strains isolated from intestinal microbiota of dogs and their antimicrobial susceptibility

Anaerobe ◽  
2014 ◽  
Vol 28 ◽  
pp. 24-28 ◽  
Author(s):  
Janice Oliveira Silva ◽  
Ana Catarina Martins Reis ◽  
Carlos Quesada-Gómez ◽  
Adriana Queiroz Pinheiro ◽  
Rosemary Souza Freire ◽  
...  
Keyword(s):  
Intestinal Microbiota ◽  
Antimicrobial Susceptibility ◽  
Biofilm Formation ◽  
Bacteroides Fragilis ◽  
Bacteroides Fragilis Group ◽  
Vitro Effect

scholarly journals Effect of pH on in vitro antimicrobial susceptibility of the Bacteroides fragilis group.

1997 ◽  
Vol 41 (9) ◽  
pp. 2047-2049 ◽  
Author(s):  
M E Falagas ◽  
L McDermott ◽  
D R Snydman
Keyword(s):  
Antimicrobial Susceptibility ◽  
Ph Effect ◽  
Geometric Mean ◽  
Bacteroides Fragilis ◽  
Acidic Ph ◽  
Effect Of Ph ◽  
Bacteroides Fragilis Group ◽  
Group Species

We studied the effect of pH (7.1, 6.3, and 5.8) on the in vitro susceptibilities of 59 isolates of Bacteroides fragilis and 60 isolates of other B. fragilis group species to trovafloxacin, ciprofloxacin, clindamycin, ampicillin-sulbactam, piperacillin-tazobactam, imipenem, and meropenem. For each agent tested the geometric mean MIC was highest at pH 5.8, intermediate at pH 6.3, and lowest at pH 7.1. The magnitude of the pH effect varied greatly among different antibiotics. These data show that an acidic pH decreases the in vitro susceptibilities of the B. fragilis group to several antibiotics.

scholarly journals Comparative in vitro activities of trovafloxacin (CP 99,219) and other antimicrobials against clinically significant anaerobes.

1997 ◽  
Vol 41 (2) ◽  
pp. 484-487 ◽  
Author(s):  
K E Aldridge ◽  
D Ashcraft ◽  
K A Bowman
Keyword(s):  
Bacteroides Fragilis ◽  
Bacteroides Fragilis Group ◽  
Clinically Significant

A total of 590 strains of clinically important anaerobes were tested to determine their susceptibility to trovafloxacin. Overall, trovafloxacin had a mode MIC of 0.25 micrograms/ml and a MIC at which 90% of the isolates were inhibited of 1 micrograms/ml and had activity comparable to that of metronidazole. Trovafloxacin was 8-, 8-, 16-, 32-, and 64-fold more active than ampicillin-sulbactam, clindamycin, ciprofloxacin, cefoxitin, and cefotetan, respectively. Of the Bacteroides fragilis group, 97% of the isolates were inhibited by trovafloxacin at 21 micrograms/ml, and trovafloxacin was more active than ciprofloxacin, cefoxitin, cefotetan, ampicillin-sulbactam, and clindamycin against Clostridium, Fusobacterium, Porphyromonas, and Prevotella strains.

scholarly journals In Vitro Activity of Tedizolid Compared to Linezolid and Five Other Antimicrobial Agents against 332 Anaerobic Isolates, Including Bacteroides fragilis Group, Prevotella, Porphyromonas, and Veillonella Species

2020 ◽  
Vol 64 (9) ◽  
Author(s):  
Ellie J. C. Goldstein ◽  
C. Vreni Merriam ◽  
Diane M. Citron
Keyword(s):  
Staphylococcus Aureus ◽  
Antimicrobial Agents ◽  
Bacteroides Fragilis ◽  
Vitro Activity ◽  
Mixed Infections ◽  
In Vitro Activity ◽  
Content Type ◽  
Bacteroides Fragilis Group ◽  
Group Species

ABSTRACT Tedizolid’s anaerobic activity is unappreciated. In this study, it was active against all 332 anaerobic isolates tested at ≤2 μg/ml except Bilophila wadsworthia and was more active than linezolid against Bacteroides fragilis group species (MIC90, 1 μg/ml versus 2 to 4 μg/ml). Tedizolid was active against Gram-positive anaerobes (MIC90 for clostridia, 0.25 to 1 μg/ml; MIC90 for anaerobic cocci, ≤0.06 to 0.25 μg/ml). Our data coupled with clinical reports indicate that clinicians should consider its use in mixed infections where Staphylococcus aureus and anaerobes are involved.

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