P116 REALISE (REAL-LIFE USE AND SAFETY OF EPIT) STUDY: HEALTH-RELATED QUALITY OF LIFE CHANGES DURING TREATMENT

2021 ◽  
Vol 127 (5) ◽  
pp. S44
Author(s):  
D. Siri ◽  
P. Bégin ◽  
R. Gagnon ◽  
G. Sussman ◽  
R. Oriel ◽  
...  
2021 ◽  
pp. 1-6
Author(s):  
Cihat Uzunköprü ◽  
Yesim Beckmann ◽  
Sabiha Türe

<b><i>Introduction:</i></b> The primary aim of the present study was to evaluate the long-term efficacy of fingolimod in patients with multiple sclerosis (MS); secondary aims were to describe the safety of fingolimod with the evaluation of treatment satisfaction and impact on the quality of life in real life. <b><i>Methods:</i></b> We collected clinical, demographical, neuroradiological, and treatment data, including pre- and posttreatment status health-related quality of life from 286 MS patients consecutively treated with fingolimod. Clinical assessment was based on the Expanded Disability Status Scale (EDSS), and quality of life assessment was performed with MS-related quality of life inventory (MSQOLI). The data were recorded at baseline and every 6 months for 2 years. <b><i>Results:</i></b> One hundred and fourteen males and 172 females were enrolled. The annualized relapse rate and EDSS showed a statistically significant reduction during the observation period (<i>p</i> &#x3c; 0.001). The patients also demonstrated substantial improvements in magnetic resonance imaging (MRI) outcomes (<i>p</i> &#x3c; 0.001). Health-related quality of life scores improved significantly between baseline and 24-month visit (<i>p</i> &#x3c; 0.001). No serious adverse events occurred. <b><i>Conclusion:</i></b> In our cohort, fingolimod treatment was associated with reduced relapse, MRI activity, and improved EDSS and MSQOLI scores. Additionally, fingolimod has been able to maintain its effectiveness over a considerable long period of treatment.


2013 ◽  
Vol 14 (1) ◽  
pp. e8-e15 ◽  
Author(s):  
Francisco Cunha ◽  
Teresa Mota ◽  
Armando Teixeira-Pinto ◽  
Leonor Carvalho ◽  
João Estrada ◽  
...  

2004 ◽  
Vol 98 (12) ◽  
pp. 1195-1202 ◽  
Author(s):  
Milo A. Puhan ◽  
Michaela Behnke ◽  
P.J. Devereaux ◽  
Victor M. Montori ◽  
Otto Braendli ◽  
...  

2019 ◽  
Vol 30 ◽  
pp. ii48
Author(s):  
M. Pérol ◽  
A. Dixmier ◽  
F. Barlesi ◽  
D. Debieuvre ◽  
C. Raspaud ◽  
...  

Obesity ◽  
2020 ◽  
Vol 28 (3) ◽  
pp. 669-675 ◽  
Author(s):  
Erin Takemoto ◽  
Bruce M. Wolfe ◽  
Corey L. Nagel ◽  
Janne Boone‐Heinonen

2009 ◽  
Vol 123 (2) ◽  
pp. S161-S161
Author(s):  
F. Braido ◽  
I. Baiardini ◽  
S. Balestracci ◽  
V. Ghiglione ◽  
E. Stagi ◽  
...  

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