scholarly journals Inhibition of hepatitis E virus replication by peptide-conjugated morpholino oligomers

2015 ◽  
Vol 120 ◽  
pp. 134-139 ◽  
Author(s):  
Yuchen Nan ◽  
Zexu Ma ◽  
Harilakshmi Kannan ◽  
David A. Stein ◽  
Patrick I. Iversen ◽  
...  
Keyword(s):  
Virus Replication ◽  
Hepatitis E Virus ◽  
Hepatitis E

scholarly journals Pan-Genotype Hepatitis E Virus Replication in Stem Cell–Derived Hepatocellular Systems

2018 ◽  
Vol 154 (3) ◽  
pp. 663-674.e7 ◽  
Author(s):  
Xianfang Wu ◽  
Viet Loan Dao Thi ◽  
Peng Liu ◽  
Constantin N. Takacs ◽  
Kuanhui Xiang ◽  
...  
Keyword(s):  
Stem Cell ◽  
Virus Replication ◽  
Hepatitis E Virus ◽  
Hepatitis E

RIG-I Inhibits Hepatitis E Virus Replication by Simultaneously Activating JAK-STAT and NFKB Pathways

2016 ◽  
Vol 64 (2) ◽  
pp. S518
Author(s):  
L. Xu ◽  
W. Wang ◽  
X. Zhou ◽  
Y. Wang ◽  
Y. Yin ◽  
...  
Keyword(s):  
Virus Replication ◽  
Hepatitis E Virus ◽  
Hepatitis E

scholarly journals Hepatitis E virus replication involves alternating negative- and positive-sense RNA synthesis

2010 ◽  
Vol 92 (3) ◽  
pp. 572-581 ◽  
Author(s):  
S. P. K. Varma ◽  
A. Kumar ◽  
N. Kapur ◽  
H. Durgapal ◽  
S. K. Acharya ◽  
...  
Keyword(s):  
Virus Replication ◽  
Hepatitis E Virus ◽  
Rna Synthesis ◽  
Hepatitis E ◽  
Positive Sense

2’-C-methylcytidine inhibits hepatitis E virus replication but antagonizing ribavirin

2017 ◽  
Vol 66 (1) ◽  
pp. S471-S472
Author(s):  
C. Qu ◽  
W. Wang ◽  
L. Xu ◽  
Y. Yin ◽  
Q. Pan ◽  
...  
Keyword(s):  
Virus Replication ◽  
Hepatitis E Virus ◽  
Hepatitis E

scholarly journals Full-length MAVS Inhibits Hepatitis E Virus Replication Dependent of JAK Signaling

2021 ◽  
Author(s):  
Changbo Qu ◽  
Yang Li ◽  
Yunlong Li ◽  
Yihang Pan
Keyword(s):  
Acute Hepatitis ◽  
Virus Replication ◽  
Hepatitis E Virus ◽  
Hepatitis E ◽  
Antiviral Signaling ◽  
Interferon Stimulated Genes ◽  
Mitochondrial Antiviral Signaling ◽  
Signaling Activation ◽  
Transcriptional Induction ◽  
Mitochondrial Antiviral Signaling Protein

Abstract Hepatitis E virus (HEV) infection is the leading cause of acute hepatitis worldwide. Mitochondrial antiviral signaling protein (MAVS)-mediated interferon (IFN) response plays a pivotal role in the hepatic antiviral immunity. However, little is known about the effects of overexpression of MAVS on HEV infection. Here, we studied the effects of FL-MAVS on HEV. We found that overexpression of FL-MAVS profoundly inhibited HEV replication. The overexpression of FL-MAVS is accompanied by the secretion of functional IFNs and transcriptional induction of interferon stimulated genes (ISGs). Furthermore, we showed that the anti-HEV effect of FL-MAVS is largely dependent of the JAK signaling activation.

scholarly journals Apolipoprotein E polymorphisms and their protective effect on hepatitis E virus replication

Hepatology ◽  
2016 ◽  
Vol 64 (6) ◽  
pp. 2274-2276 ◽  
Author(s):  
Romy Weller ◽  
Daniel Todt ◽  
Michael Engelmann ◽  
Martina Friesland ◽  
Heiner Wedemeyer ◽  
...  
Keyword(s):  
Protective Effect ◽  
Apolipoprotein E ◽  
Virus Replication ◽  
Hepatitis E Virus ◽  
Hepatitis E
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