P-35 NONINVASIVE PREDICTORS OF ESOPHAGEAL VARICES IN PATIENTS WITH HEPATOSPLENIC SCHISTOSOMIASIS MANSONI: MULTICENTER STUDY

Antibody response to Salmonella typhi O and H antigens was evaluated in 24 individuals with either hepatointestinal or hepatosplenic schistosomiasis mansoni before and after typhoid vaccination, and compared with that of non-infected controls. Before vaccination, Schistosoma-infected patients showed a higher frequency of positive antibody to O antigen and the same frequency to H antigen when compared with that of healthy individuals. However, those with hepatosplenic schistosomiasis showed higher titres of antibody to H antigen than those with hepatointestinal disease or healthy individuals. Infected subjects, particularly those with hepatointestinal disease, showed a decreased response after typhoid vaccine. Tins diminished ability to mount an immune response towards typhoid antigens dining schistosomiasis may interfere ivith the clearance of the bacteria from blood stream and, therefore, play a role in the prolonged survival of salmonella as obsewed in some patients with chronic salmonellosis associated with schistosomiasis.

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Sonographic features of portal hypertension in Schistosomiasis Mansoni

Revista do Instituto de Medicina Tropical de São Paulo ◽

10.1590/s0036-46651994000400008 ◽

1994 ◽

Vol 36 (4) ◽

pp. 355-361 ◽

Cited By ~ 25

Author(s):

Rogerio Augusto Pinto-Silva ◽

Wilson Luiz Abrantes ◽

Carlos Maurício Figueiredo Antunes ◽

Jose Roberto Lambertucci

Keyword(s):

Portal Hypertension ◽

Portal Vein ◽

Operating Characteristic ◽

Characteristic Curve ◽

Splenic Vein ◽

Diagnostic Value ◽

Schistosomiasis Mansoni ◽

Upper Limit ◽

Splenic Hilus ◽

Hepatosplenic Schistosomiasis

The diagnostic value of real-time sonography in the study of portal hypertension was assessed in 66 patients with hepatosplenic schistosomiasis mansoni, all with Symmers's fibrosis and esophageal varices. Seventy-one individuals without schistosomiasis were selected as controls. The inner diameters of the portal vessels were measured by sonography in all patients and controls: splenoportography was also performed in the schistosomal group. Intra-splenic pressure was over 30 cm of water in 44 of 60 patients with schistosomiasis. The upper limit of normality for portal vessel diameters was set through receiver operating characteristic curve at 12 mm for portal vein, 9 mm for splenic vein at splenic hilus, and 9 mm for superior mesenteric vein. The best discriminative vein for the diagnosis of portal hypertension was the splenic vein followed by the portal vein. A direct correlation was observed between the diameter of the splenic vein, measured by sonography, and the intra-splenic pressure. Except for the paraumbilical and mesenteric veins, more frequently identified by sonography, there was no statistical difference in the frequency of visualization of splanchnic vessels by sonography or splenoportography.

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Relation of morphometric and hemodynamic variables in hepatosplenic schistosomiasis mansoni (HSS)

Hepatology ◽

10.1016/0270-9139(94)90713-7 ◽

1994 ◽

Vol 19 (4) ◽

pp. I137

Author(s):

M Vianna

Keyword(s):

Hemodynamic Variables ◽

Schistosomiasis Mansoni ◽

Hepatosplenic Schistosomiasis

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Chronic glomerulonephritis associated with hepatosplenic schistosomiasis mansoni

Revista do Instituto de Medicina Tropical de São Paulo ◽

10.1590/s0036-46651987000300008 ◽

1987 ◽

Vol 29 (3) ◽

pp. 162-167 ◽

Cited By ~ 4

Author(s):

Eduardo Antonio Gonçalves Ramos ◽

Zilton A. Andrade

Keyword(s):

Renal Disease ◽

The Other ◽

Glomerular Sclerosis ◽

Chronic Glomerulonephritis ◽

Parasitic Diseases ◽

Schistosomiasis Mansoni ◽

Other Hand ◽

Focal Glomerular Sclerosis ◽

Hepatosplenic Schistosomiasis

In a series of 36 cases of renal disease associated with hepatosplenic schistosomiasis the following morphologic types of glomerulonephritis were found: mesangio-capillary (33.2%), mesangial proliferative (25.0%), focal glomerular sclerosis (16.7%) and sclerosing glomerulonephritis (8.3%). No significant statistical differences were found when these results were compared with those from 36 cases of glomerulonephritis not associated with hepatosplenic disease. On the other hand, endocapillary glomerulonephritis was found to be predominant in the latter group of cases. These results did not substantiate the assumption that mesangio-capillary glomerulonephritis is specifically related to hepatosplenic schistosomiais. However, if the types of glomerulonephritis that predominantly involve the me-sangium are considered together, they are significantly associated with hepatosplenic schistosomiasis. Mesangial involvement is known to occur in other parasitic diseases and that may be related to a common immunopathogenesis.

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