Diminished insulin sensitivity is associated with altered brain activation to food cues and with risk for obesity – Implications for individuals born small for gestational age

Appetite ◽  
2021 ◽  
pp. 105799
Author(s):  
Amanda B. Mucellini ◽  
Patrícia M. Miguel ◽  
Roberta Dalle Molle ◽  
Danitsa M. Rodrigues ◽  
Tania D. Machado ◽  
...  
Keyword(s):  
Insulin Sensitivity ◽  
Gestational Age ◽  
Small For Gestational Age ◽  
Brain Activation ◽  
Food Cues

Reduced insulin sensitivity during growth hormone therapy for short children born small for gestational age

2003 ◽  
Vol 142 (2) ◽  
pp. 113-116 ◽  
Author(s):  
Wayne S. Cutfield ◽  
Wendy E. Jackson ◽  
Craig Jefferies ◽  
Elizabeth M. Robinson ◽  
Bernhard H. Breier ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Insulin Sensitivity ◽  
Hormone Therapy ◽  
Gestational Age ◽  
Small For Gestational Age ◽  
Growth Hormone Therapy ◽  
Short Children

Insulin Sensitivity Decreases in Short Children Born Small for Gestational Age Treated with Growth Hormone

2009 ◽  
Vol 154 (4) ◽  
pp. 509-513 ◽  
Author(s):  
Sara Bachmann ◽  
Susanne Bechtold ◽  
Walter Bonfig ◽  
Stephanie Putzker ◽  
Matthias Buckl ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Insulin Sensitivity ◽  
Gestational Age ◽  
Small For Gestational Age ◽  
Short Children

scholarly journals  -Cell Capacity and Insulin Sensitivity in Prepubertal Children Born Small for Gestational Age: Influence of Body Size During Childhood

Diabetes ◽  
2003 ◽  
Vol 52 (7) ◽  
pp. 1756-1760 ◽  
Author(s):  
M. A. Veening ◽  
M. M. van Weissenbruch ◽  
R. J. Heine ◽  
H. A. Delemarre-van de Waal
Keyword(s):  
Body Size ◽  
Insulin Sensitivity ◽  
Gestational Age ◽  
Small For Gestational Age ◽  
Prepubertal Children ◽  
Cell Capacity

Hormonal regulation of postnatal growth from birth to age six months in Small-for-Gestational - Age children

2016 ◽  
Vol 7 (3) ◽  
pp. 104-110
Author(s):  
Kristina F Islamova ◽  
Dmitriy O Ivanov ◽  
Yuriy V Petrenko ◽  
Elizaveta A Kurzina
Keyword(s):  
Insulin Sensitivity ◽  
Gestational Age ◽  
Small For Gestational Age ◽  
Hormonal Regulation ◽  
Later Life ◽  
Postnatal Growth ◽  
Blood Levels ◽  
Model Assessment ◽  
Appropriate For Gestational Age ◽  
Catch Up

This article is devoted to the investigation hormonal mechanisms of postnatal growth from birth to age six months in small for gestational age children (SGA) with asymmetrical and asymmetrical IUGR. The IGF-1 and GH levels, insulin sensitivity (by homeostasis model assessment (HOMA-IR)) were measured blood at 3 and 6 months of age. The prospective study includes 40 SGA infants (group 1) - 24 - with asymmetrical (1a) and 16 with symmetrical IUGR babies (1b) and 17 appropriate for gestational age (AGA) infants (group 2). Most SGA infants showed rapid, or “catch-up” postnatal growth. Symmetrical IUGR infants with “catch-up” growth had higher IGF-1 and growth GH levels at 3 month of age than asymmetrical IUGR with “catch-up” growth (p < 0,05). From 3 to 6 months of age 77 % of infants with “catch-up” growth showed retardation of growth velocity. At 6 month of age SGA infants with “catch-up” growth had lower IGF-1, GH blood levels and HOMA-IR than at 3 months of age (p < 0,05). Infants without “catch-up” growth had similar hormone levels at 3 and 6 months of age. We suppose, that these changes of “GH - IGF-1” axis and insulin sensitivity at age 3 and 6 months in SGA infants are the mechanisms, which promote the postnatal growth. It can be assumed that the same mechanisms may underlie metabolic disorders in later life.

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