scholarly journals One-pot production of 18F-biotin by conjugation with 18F-FDG for pre-targeted imaging: Synthesis and radio-labelling of a PEGylated precursor

2011 ◽  
Vol 69 (2) ◽  
pp. 418-422 ◽  
Author(s):  
Michael Simpson ◽  
Laurent Trembleau ◽  
Richard W. Cheyne ◽  
Tim A.D. Smith
Keyword(s):  
Targeted Imaging ◽  
One Pot ◽  
18F Fdg ◽  
Radio Labelling

Novel multifunctional nano-hybrid polyhedral oligomeric silsesquioxane-based molecules with high cell permeability: molecular design and application for diagnosis and treatment of tumors

Nanoscale ◽  
2021 ◽  
Vol 13 (5) ◽  
pp. 2982-2994
Author(s):  
Gang Wei ◽  
Kezhen Zhang ◽  
Yuanlong Gu ◽  
Shanyi Guang ◽  
Jihong Feng ◽  
...  
Keyword(s):  
Folic Acid ◽  
Molecular Design ◽  
Polyhedral Oligomeric Silsesquioxane ◽  
Cell Permeability ◽  
Targeted Imaging ◽  
High Cell ◽  
One Pot ◽  
Peg 400 ◽  
Multifunctional Molecules ◽  
Oligomeric Silsesquioxane

Octathiol POSS was used to connect PEG-400, hexene, folic acid, fluorescein, and thioguanine using a simple and efficient photo-initiated one-pot method to prepare multifunctional molecules, which have targeted imaging and therapeutic functions.

scholarly journals One-pot aqueous synthesis of highly strained CdTe/CdS/ZnS nanocrystals and their interactions with cells

RSC Advances ◽  
2015 ◽  
Vol 5 (10) ◽  
pp. 7485-7494 ◽  
Author(s):  
Mehriban Ulusoy ◽  
Johanna-Gabriela Walter ◽  
Antonina Lavrentieva ◽  
Imme Kretschmer ◽  
Lydia Sandiford ◽  
...  
Keyword(s):  
Cancer Cells ◽  
Targeted Imaging ◽  
Thick Shell ◽  
One Pot ◽  
Aqueous Synthesis ◽  
Small Core ◽  
Cds Nanocrystals ◽  
Zns Nanocrystals ◽  
Highly Strained

An aqueous approach enhancing the properties of small-core/thick-shell CdTe/CdS nanocrystals by deposition of an outer ZnS shell was developed. The as-prepared nanocrystals were conjugated with aptamer for the targeted imaging of cancer cells.

Back-to-back “one-pot” [18F]FDG syntheses in a single Siemens-CTI chemistry process control unit

1996 ◽  
Vol 23 (4) ◽  
pp. 497-501 ◽  
Author(s):  
Bruce H. Mock ◽  
Michael T. Vavrek ◽  
G.Keith Mulholland
Keyword(s):  
Process Control ◽  
Control Unit ◽  
One Pot ◽  
18F Fdg

In Vivo Tracking of Macrophage Activated Killer Cells to Sites of Metastatic Ovarian Carcinoma.

Blood ◽  
2005 ◽  
Vol 106 (11) ◽  
pp. 3874-3874
Author(s):  
David S. Ritchie ◽  
Linda Mileshkin ◽  
Dominic M. Wall ◽  
Jacques Bartholyens ◽  
Mick Thompson ◽  
...  
Keyword(s):  
Ovarian Carcinoma ◽  
Epithelial Ovarian Carcinoma ◽  
Cell Labelling ◽  
In Vivo Distribution ◽  
18F Fdg ◽  
Cancer Immunotherapies ◽  
Radio Labelling ◽  
Established Technique ◽  
Selection Of

Abstract Radio-labelling of blood cells is an established technique for evaluating in vivo migration to sites of pathology such as infection and haemorrhage. We describe the use of two methods of cell labelling for tracking the destination of autologous-derived macrophage activated killer (MAK) cells linked to the bi-specific anti-her2neu antibody MDX-H210 delivered either by intravenous (iv) or intraperitoneal (ip) injection in ten patients with peritoneal relapse of epithelial ovarian carcinoma. Our results demonstrate the feasibility of generating high numbers and purity of GMP quality MAK cells, which can be efficiently radiolabeled. MAK cell administration produced minimal infusional toxicity and demonstrated a reproducible pattern of in vivo distribution to the lungs, liver and spleen in addition to active in vivo tracking to sites of known tumor following either iv (8 of 16 infusions) or ip (4 of 6 infusions) using either 18F-FDG or 111In-labelled cells. The addition of MDX-H210 monoclonal antibody did not alter the distribution of cells to tumor sites, but did alter the in vivo distribution of cells administered by iv injection. This study demonstrates that cellular cancer immunotherapies may be successfully delivered to sites of active tumor and allows selection of those patients who may benefit from these approaches.

Comparison of Fluorine(18)-fluorodeoxyglucose and Gallium(68)-citrate PET/CT in patients with tuberculosis

2019 ◽  
Vol 58 (05) ◽  
pp. 371-378
Author(s):  
Alfred O. Ankrah ◽  
Ismaheel O. Lawal ◽  
Tebatso M.G. Boshomane ◽  
Hans C. Klein ◽  
Thomas Ebenhan ◽  
...  
Keyword(s):  
Tracer Uptake ◽  
Pet Ct ◽  
The Mean ◽  
18F Fdg ◽  
Definition Of ◽  
Gallium 68 ◽  
Attending Physician ◽  
Pet Scans ◽  
The Brain

Abstract 18F-FDG and 68Ga-citrate PET/CT have both been shown to be useful in the management of tuberculosis (TB). We compared the abnormal PET findings of 18F-FDG- and 68Ga-citrate-PET/CT in patients with TB. Methods Patients with TB on anti-TB therapy were included. Patients had a set of PET scans consisting of both 18F-FDG and 68Ga-citrate. Abnormal lesions were identified, and the two sets of scans were compared. The scan findings were correlated to the clinical data as provided by the attending physician. Results 46 PET/CT scans were performed in 18 patients, 11 (61 %) were female, and the mean age was 35.7 ± 13.5 years. Five patients also had both studies for follow-up reasons during the use of anti-TB therapy. Thirteen patients were co-infected with HIV. 18F-FDG detected more lesions than 68Ga-citrate (261 vs. 166, p < 0.0001). 68Ga-citrate showed a better definition of intracerebral lesions due to the absence of tracer uptake in the brain. The mean SUVmax was higher for 18F-FDG compared to 68Ga-citrate (5.73 vs. 3.01, p < 0.0001). We found a significant correlation between the SUVmax of lesions that were determined by both tracers (r = 0.4968, p < 0.0001). Conclusion Preliminary data shows 18F-FDG-PET detects more abnormal lesions in TB compared to 68Ga-citrate. However, 68Ga-citrate has better lesion definition in the brain and is therefore especially useful when intracranial TB is suspected.

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