Novel multifunctional nano-hybrid polyhedral oligomeric silsesquioxane-based molecules with high cell permeability: molecular design and application for diagnosis and treatment of tumors

Nanoscale ◽  
2021 ◽  
Vol 13 (5) ◽  
pp. 2982-2994
Author(s):  
Gang Wei ◽  
Kezhen Zhang ◽  
Yuanlong Gu ◽  
Shanyi Guang ◽  
Jihong Feng ◽  
...  
Keyword(s):  
Folic Acid ◽  
Molecular Design ◽  
Polyhedral Oligomeric Silsesquioxane ◽  
Cell Permeability ◽  
Targeted Imaging ◽  
High Cell ◽  
One Pot ◽  
Peg 400 ◽  
Multifunctional Molecules ◽  
Oligomeric Silsesquioxane

Octathiol POSS was used to connect PEG-400, hexene, folic acid, fluorescein, and thioguanine using a simple and efficient photo-initiated one-pot method to prepare multifunctional molecules, which have targeted imaging and therapeutic functions.

scholarly journals A Rapid One-Pot Synthesis of Novel High-Purity Methacrylic Phosphonic Acid (PA)-Based Polyhedral Oligomeric Silsesquioxane (POSS) Frameworks via Thiol-Ene Click Reaction

Polymers ◽  
2017 ◽  
Vol 9 (12) ◽  
pp. 192 ◽  
Author(s):  
K. Karuppasamy ◽  
K. Prasanna ◽  
Dhanasekaran Vikraman ◽  
Hyun-Seok Kim ◽  
A. Kathalingam ◽  
...  
Keyword(s):  
Phosphonic Acid ◽  
High Purity ◽  
Click Reaction ◽  
Polyhedral Oligomeric Silsesquioxane ◽  
One Pot ◽  
One Pot Synthesis ◽  
Oligomeric Silsesquioxane

Fluorinated polyhedral oligomeric silsesquioxane-based shape amphiphiles: molecular design, topological variation, and facile synthesis

2012 ◽  
Vol 3 (8) ◽  
pp. 2112 ◽  
Author(s):  
Jinlin He ◽  
Kan Yue ◽  
Yuqing Liu ◽  
Xinfei Yu ◽  
Peihong Ni ◽  
...  
Keyword(s):  
Molecular Design ◽  
Polyhedral Oligomeric Silsesquioxane ◽  
Facile Synthesis ◽  
Oligomeric Silsesquioxane

Facile one-pot preparation of an imidazolium embedded C8 hybrid monolith using polyhedral oligomeric silsesquioxane for capillary liquid chromatography

RSC Advances ◽  
2015 ◽  
Vol 5 (111) ◽  
pp. 91436-91440 ◽  
Author(s):  
Niu Zhang ◽  
Lu Zhang ◽  
Xiaoqiang Qiao ◽  
Yongli Wang ◽  
Hongyuan Yan ◽  
...  
Keyword(s):  
Liquid Chromatography ◽  
Monolithic Column ◽  
Polyhedral Oligomeric Silsesquioxane ◽  
Capillary Liquid Chromatography ◽  
One Pot ◽  
Oligomeric Silsesquioxane ◽  
Capillary Liquid ◽  
Hybrid Monolithic Column

In this study, a novel imidazolium embedded C8 hybrid monolithic column based on polyhedral oligomeric silsesquioxane (POSS) was developed.

POSS and imidazolium-constructed ionic porous hypercrosslinked polymers with multiple active sites for synergistic catalytic CO2 transformation

2021 ◽  
Author(s):  
Yadong Zhang ◽  
Ke Liu ◽  
Lei Wu ◽  
He Huang ◽  
Zixuan Xu ◽  
...  
Keyword(s):  
Active Sites ◽  
Polyhedral Oligomeric Silsesquioxane ◽  
One Pot ◽  
Oligomeric Silsesquioxane ◽  
Hypercrosslinked Polymers ◽  
Co2 Transformation

In this work, we reported a facile one-pot approach to construct polyhedral oligomeric silsesquioxane (POSS) and imidazolium-based ionic porous hypercrosslinked polymers (denoted iPHCPs) with multiple active sites towards efficient catalytic...

Simplistic one-pot synthesis of an inorganic–organic cubic caged material: a new interface for detecting toxic bisphenol-A electrochemically

2020 ◽  
Vol 44 (46) ◽  
pp. 20192-20202
Author(s):  
Dhurkasini Ananthakrishnan ◽  
Harikrishnan Venkatesvaran ◽  
Aarthi Kannan ◽  
Sakthivel Gandhi
Keyword(s):  
Bisphenol A ◽  
Functional Groups ◽  
Polyhedral Oligomeric Silsesquioxane ◽  
Electrochemical Sensing ◽  
Hybrid Nanomaterials ◽  
One Pot ◽  
One Pot Synthesis ◽  
Oligomeric Silsesquioxane

Polyhedral oligomeric silsesquioxane (POSS) based hybrid nanomaterials have been terminally functionalised with three different functional groups and are newly explored for the electrochemical sensing of bisphenol A.

Model Polyhedral Oligomeric Silsesquioxane Thin Films for Coating Applications

2002 ◽  
Author(s):  
Brent Viers ◽  
Shawn Phillips ◽  
Timothy Haddad ◽  
Alan Esker ◽  
Joe Polidan
Keyword(s):  
Thin Films ◽  
Polyhedral Oligomeric Silsesquioxane ◽  
Oligomeric Silsesquioxane

Polyhedral Oligomeric Silsesquioxane /Platelets Rich Plasma/Gelrite-Based Hydrogel Scaffold for Bone Tissue Engineering

2020 ◽  
Vol 26 (26) ◽  
pp. 3147-3160
Author(s):  
Saeedeh Ahmadipour ◽  
Jaleh Varshosaz ◽  
Batool Hashemibeni ◽  
Leila Safaeian ◽  
Maziar Manshaei
Keyword(s):  
Bone Fractures ◽  
Compressive Strain ◽  
Gelation Time ◽  
Polyhedral Oligomeric Silsesquioxane ◽  
Local Drug Delivery ◽  
Gelling Agent ◽  
Control Group ◽  
Hydrogel Scaffold ◽  
Alizarin Red ◽  
Oligomeric Silsesquioxane

Background: Polyhedral oligomeric silsesquioxane (POSS) is a monomer with silicon structure and an internal nanometric cage. Objective: The purpose of this study was to provide an injectable hydrogel that could be easily located in open or closed bone fractures and injuries, and also to reduce the possible risks of infections caused by bone graft either as an allograft or an autograft. Methods: Various formulations of temperature sensitive hydrogels containing hydroxyapatite, Gelrite, POSS and platelets rich plasma (PRP), such as the co-gelling agent and cell growth enhancer, were prepared. The hydrogels were characterized for their injectability, gelation time, phase transition temperature and viscosity. Other physical properties of the optimized formulation including compressive stress, compressive strain and Young’s modulus as mechanical properties, as well as storage and loss modulus, swelling ratio, biodegradation behavior and cell toxicity as rheometrical parameters were studied on human osteoblast MG-63 cells. Alizarin red tests were conducted to study the qualitative and quantitative osteogenic capability of the designed scaffold, and the cell adhesion to the scaffold was visualized by scanning electron microscopy. Results: The results demonstrated that the hydrogel scaffold mechanical force and injectability were 3.34±0.44 Mpa and 12.57 N, respectively. Moreover, the scaffold showed higher calcium granules production in alizarin red staining compared to the control group. The proliferation of the cells in G4.5H1P0.03PRP10 formulation was significantly higher than in other formulations (p<0.05). Conclusion: The optimized Gelrite/Hydroxyapatite/POSS/PRP hydrogel scaffold has useful impacts on osteoblasts activity, and may be beneficial for local drug delivery in complications including a break or bone loss.

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