Simultaneous determination of drug surface concentration and polymer degradation kinetics in biodegradable polymer/drug membranes: a model drug delivery system

2004 ◽  
Vol 231-232 ◽  
pp. 442-446 ◽  
Author(s):  
Joo-Woon Lee ◽  
Joseph A. Gardella
Keyword(s):  
Drug Delivery ◽  
Simultaneous Determination ◽  
Drug Delivery System ◽  
Delivery System ◽  
Biodegradable Polymer ◽  
Degradation Kinetics ◽  
Polymer Degradation ◽  
Surface Concentration ◽  
Model Drug

scholarly journals Development and Validation of RP-HPLC Method for Simultaneous Determination of Curcumin and Quercetin in Extracts, Marketed Formulations, and Self-Nanoemulsifying Drug Delivery System

Re:GEN Open ◽  
2021 ◽  
Vol 1 (1) ◽  
pp. 43-52
Author(s):  
Rubiya Khursheed ◽  
Sachin Kumar Singh ◽  
Bhupinder Kapoor ◽  
Monica Gulati ◽  
Sheetu Wadhwa ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Simultaneous Determination ◽  
Drug Delivery System ◽  
Delivery System ◽  
Hplc Method ◽  
Rp Hplc ◽  
Development And Validation

scholarly journals A pH‐Triggered Polymer Degradation or Drug Delivery System by Light‐Mediated Cis / Trans Isomerization of o ‐Hydroxy Cinnamates

2021 ◽  
pp. 2100213
Author(s):  
Alex Abramov ◽  
Binoy Maiti ◽  
Ina Keridou ◽  
Jordi Puiggalí ◽  
Oliver Reiser ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Polymer Degradation ◽  
Trans Isomerization

Processing of Biodegradable Polymer Composites as A Drug Delivery System in Vitro

1999 ◽  
Vol 14 (4) ◽  
pp. 322-325
Author(s):  
S.-J. Liu ◽  
C.-H. Tsai ◽  
S.-S. Lin ◽  
S. W.-N. Ueng
Keyword(s):  
Drug Delivery ◽  
Polymer Composites ◽  
Drug Delivery System ◽  
Delivery System ◽  
Biodegradable Polymer

Model drug delivery system based on nanodiamonds

2011 ◽  
Vol 6 (3-4) ◽  
pp. 256-264 ◽  
Author(s):  
K. V. Purtov ◽  
A. I. Petunin ◽  
A. P. Puzyr ◽  
A. E. Burov ◽  
V. S. Bondar
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Model Drug

Investigation of Nanoscale Structure of Self-Emulsifying Drug Delivery System Containing Poorly Water-Soluble Model Drug

2014 ◽  
Vol 970 ◽  
pp. 272-278 ◽  
Author(s):  
Mont Kumpugdee-Vollrath ◽  
Yotsanan Weerapol ◽  
Karin Schrader ◽  
Pornsak Sriamornsak
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Correlation Spectroscopy ◽  
Water Soluble ◽  
Wide Range ◽  
Poorly Water Soluble ◽  
Nanoscale Structure ◽  
Model Drug ◽  
20 Nm

This work has a focus on the self-emulsifying drug delivery system (SEDDS), which can be used in pharmaceutical field for increasing bioavailability of poorly water-soluble drugs. The model drug resveratrol was used because of its poor water-solubility and is of interest because of its wide range of pharmacological effects. It is beneficial to understand the mechanism of SEDDS formation in the human body, therefore, the determination of nanoscale structure was carried out. For this purpose, small angle X-ray scattering (SAXS), photon correlation spectroscopy (PCS), and transmission electron microscopy (TEM) techniques were applied. We have found that the size and size distribution of particles were in nanometers. The inner structure of SEDDS was ordered with the lamellar distances (d-spacing) of < 20 nm. It seems that the prepared SEDDS in water form large oil drops (200-400 nm) in water as well as small micelles with the droplet size of 10-20 nm.

Proliposomes as a drug delivery system to decrease the hepatic first-pass metabolism: Case study using a model drug

2014 ◽  
Vol 64 ◽  
pp. 26-36 ◽  
Author(s):  
Sarala Yanamandra ◽  
Natarajan Venkatesan ◽  
Veeran Gowda Kadajji ◽  
Zhijun Wang ◽  
Manish Issar ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
First Pass Metabolism ◽  
First Pass ◽  
Model Drug ◽  
Pass Metabolism

Formulation and Evaluation of Pulsatile Drug Delivery System of Atenolol

2020 ◽  
Vol 6 (1) ◽  
pp. 45-49
Author(s):  
Sudipta Das ◽  
Baishali Ghosh ◽  
Surita Basu
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Ethyl Cellulose ◽  
Methyl Cellulose ◽  
Burst Release ◽  
Direct Compression ◽  
Optimum Result ◽  
Pulsatile Drug Delivery ◽  
Model Drug

The objective of the present study was formulation and evaluation of pulsatile release tablets of Atenolol. A tablet system consisting of cores which was coated with layers of swelling and rupturable coatings. Cores containing Atenolol as model drug were prepared by direct compression with appropriate ratios of lactose and microcrystalline cellulose and then coated sequentially with different ratios of an inner swelling layer containing HPMC and an outer rupturable layer of Ethyl Cellulose. The effect of level of swelling layer and rupturable coating was investigated. The different formulation press coated by using different weight ratios of Hydroxy Propyl Methyl Cellulose (HPMC) / Ethyl Cellulose (EC) / both HPMC and EC. The optimum result was achieved in formulation containing HPMC: EC weight ratios. The F3 batch achieved a highest burst release after the lag time which is applicable pulsatile drug delivery system of Atenolol.

Preparation and Physical Properties of PCL-Metoprolol Tartrate Electrospun Nanofibers as Drug Delivery System

2021 ◽  
Vol 886 ◽  
pp. 183-188
Author(s):  
Saja A. Moosa ◽  
Akram R. Jabur ◽  
Emad S. Al-Hassani
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Electrospun Nanofibers ◽  
Metoprolol Tartrate ◽  
Water Contact ◽  
High Fiber ◽  
Good Potential ◽  
Span 80 ◽  
Model Drug

Electrospinning is considered a promising technology for encapsulating and loading various drugs into nanofibers. Metoprolol tartrate (MPT), hydrophilic therapy, was used as model drug. Metoprolol tartrate was loaded into poly(ɛ-caprolactone) (PCL) via blend and emulsion electospinning. The preparation processes, morphology, chemical structure thermal properties were evaluated. FESEM showed that emulsion electospinning produce larger fiber diameters(301.775nm) when compared to fibers produced by blend electrospinning(112.463, 249.34)nm, the PCL/ span 80 and MPT-PCL by emulsion method which have high fiber diameter than pure PCL and MPT-PCL by blend method and the Tm of pure PCL nanofibers and all drug loaded scaffolds are around 60°C from DSC test, water contact angle to pure PCL electrospun mats hydrophobic character (126.2°), while PCL/span 80, and PCL-drug nanofiber mats showed hydrophilic character. Our study demonstrated the possibility of using electrospinning with a promising good potential toward sustained and controlled drug delivery system.

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