Determination of Mycoplasma hyopneumoniae-Specific IgG, IgG1, and IgG2a Titers in BALB/c Mice Induced by Mineral Oil-Based Oil-in-Water Emulsion Adjuvants Prepared Using a Self-Emulsifying Drug Delivery System

2019 ◽  
Vol 20 (1) ◽  
Author(s):  
Rakesh Bastola ◽  
Jo-Eun Seo ◽  
Gyubin Noh ◽  
Taekwang Keum ◽  
Ju Hun Kim ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Mycoplasma Hyopneumoniae ◽  
Mineral Oil ◽  
Water Emulsion ◽  
Oil In Water ◽  
Specific Igg ◽  
Oil In Water Emulsion

Natural polymer-stabilized multiple water-in-oil-in-water emulsions: a novel dermal drug delivery system for 5-fluorouracil

2013 ◽  
Vol 66 (5) ◽  
pp. 658-667 ◽  
Author(s):  
Magdalena Hoppel ◽  
Denise Mahrhauser ◽  
Christina Stallinger ◽  
Florian Wagner ◽  
Michael Wirth ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Natural Polymer ◽  
Oil In Water ◽  
Dermal Drug Delivery ◽  
Polymer Stabilized

scholarly journals Characterization of a novel oil-in-water emulsion adjuvant for swine influenza virus and Mycoplasma hyopneumoniae vaccines

Vaccine ◽  
2015 ◽  
Vol 33 (25) ◽  
pp. 2903-2908 ◽  
Author(s):  
A. Galliher-Beckley ◽  
L.K. Pappan ◽  
Rachel Madera ◽  
Y. Burakova ◽  
A. Waters ◽  
...  
Keyword(s):  
Influenza Virus ◽  
Swine Influenza Virus ◽  
Swine Influenza ◽  
Mycoplasma Hyopneumoniae ◽  
Water Emulsion ◽  
Oil In Water ◽  
Oil In Water Emulsion

Neem seed oil and gum arabic-based oil-in-water emulsions as potential ocular drug delivery system

2019 ◽  
Vol 41 (13) ◽  
pp. 1911-1924 ◽  
Author(s):  
Dilshad Quereshi ◽  
Somali Dhal ◽  
Debasis Das ◽  
Biswaranjan Mohanty ◽  
Arfat Anis ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Seed Oil ◽  
Gum Arabic ◽  
Ocular Drug Delivery ◽  
Neem Seed ◽  
Oil In Water ◽  
Neem Seed Oil

scholarly journals Preparation of Squalene Oil-Based Emulsion Adjuvants Employing a Self-Emulsifying Drug Delivery System and Assessment of Mycoplasma hyopneumoniae-Specific Antibody Titers in BALB/c Mice

Pharmaceutics ◽  
2019 ◽  
Vol 11 (12) ◽  
pp. 667
Author(s):  
Rakesh Bastola ◽  
Jo-Eun Seo ◽  
Taekwang Keum ◽  
Gyubin Noh ◽  
Jae Woong Choi ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Specific Antibody ◽  
Physical Stability ◽  
Mycoplasma Hyopneumoniae ◽  
Porcine Circovirus Type ◽  
Porcine Circovirus ◽  
Droplet Sizes ◽  
Antibody Titers

In this study, a self-emulsifying drug delivery system (SEDDS) was employed to prepare novel squalene oil-based emulsion adjuvants. Deionized water, 0.01% and 0.02% (w/v) carbomer solutions of C-971P NF and C-940 grades were used to prepare emulsions containing 3%, 5% and 10% of squalene oil. Altogether 15 candidate emulsions were prepared and used as adjuvants for the delivery of a combination vaccine containing a porcine circovirus type 2 (PCV2) antigen and inactivated Mycoplasma hyopneumoniae (J101 strain) antigen. Most of the emulsions showed droplet sizes in the submicron range and maintained zeta potential values between −40 mV to 0 mV for six months, indicating good physical stability as a vaccine adjuvant. Emulsion-based candidate adjuvants prepared with SEDDS technology stimulated IgG, IgG1 and IgG2a like a currently commercially available adjuvant, Montanide ISATM 201, and they were safe and their Mycoplasma hyopneumoniae-specific antibody titers were considered as comparable with that of Montanide ISATM 201.

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